In low-resource settings where disease burdens remain high and many health facilities lack essentials such as drugs or commodities, functional equipment, and trained personnel, poor quality of care often results and the impact can be profound. In this paper, we systematically quantify the potential gain of addressing quality of care globally using country-level data about antenatal, childbirth, and postnatal care interventions.
Methods and findings
In this study, we created deterministic models to project health outcomes if quality of care was addressed in a representative sample of 81 low- and middle-income countries (LMICs). First, available data from health facility surveys (e.g., Service Provision Assessment [SPA] and Service Availability and Readiness Assessment [SARA]) conducted 2007–2016 were linked to household surveys (e.g., Demographic and Health Surveys [DHS] and Multiple Indicator Cluster Surveys [MICS]) to estimate baseline coverage for a core subset of 19 maternal and newborn health interventions. Next, models were constructed with the Lives Saved Tool (LiST) using country-specific baseline levels in countries with a linked dataset (n = 17) and sample medians applied as a proxy in countries without linked data. Lastly, these 2016 starting baseline levels were raised to reach targets in 2020 as endline based upon country-specific utilization (e.g., proportion of women who attended 4+ antenatal visits, percentage of births delivered in a health facility) from the latest DHS or MICS population-based reports. Our findings indicate that if high-quality health systems could effectively deliver this subset of evidence-based interventions to mothers and their newborns who are already seeking care, there would be an estimated 28% decrease in maternal deaths, 28% decrease in neonatal deaths, and 22% fewer stillbirths compared to a scenario without any change or improvement in quality of care. Totals of 86,000 (range, 77,800–92,400) maternal and 0.67 million (range, 0.59 million–0.75 million) neonatal lives could be saved, and 0.52 million (range, 0.48 million–0.55 million) stillbirths could be prevented across the 81 countries in the calendar year 2020 when adequate quality care is provided at current levels of utilization. Limitations include the paucity of data to individually assess quality of care for each intervention in all LMICs and the necessary assumption that quality of care being provided among the subset of countries with linked datasets is comparable or representative of LMICs overall.
Our findings suggest that efforts to close the quality gap would still produce substantial benefits at current levels of access or utilization. With estimated mortality rate declines of 21%–32% on average, gains from this first step would be significant if quality was improved for selected antenatal, intrapartum, and postnatal interventions to benefit pregnant women and newborns seeking care. Interventions provided at or around the time of childbirth are most critical and accounted for 64% of the impact overall estimated in this quality improvement analysis.
Why was this study done?
- In low- and middle-income countries, health systems struggle to provide high-quality medical care to pregnant women and their newborns in need.
- Delivery of key health interventions is critical to save lives and prevent morbidity and mortality in high-burden settings.
- The impact of extant or poor quality of care at a population level is poorly understood, and quantifying the benefits of improving quality among those already seeking or accessing care would be a critical first step for prioritization.
What did the researchers do and find?
- To examine the global impact of improvement in the quality of care, we used a linking approach, which combines health facility and population-level survey data to estimate baseline for a subset of important evidence-based interventions.
- Intervention coverage trends were modeled in 81 countries by setting current levels of reported utilization as the final country-specific targets for 2020.
- If those seeking medical attention arrived at facilities reimagined with adequate resources and receive high-quality care, our systematic tally indicates that almost one quarter of the maternal deaths, neonatal deaths, and stillbirths would be preventable during the period 2016–2020 if the gaps in quality of care were eliminated.
What do these findings mean?
- Countries and current health systems are far from ensuring that skilled providers with adequate supplies are providing timely and appropriate healthcare to existing populations in need. Our analysis of potential gains quantifies the consequences of these missed opportunities, ranging from the prenatal to postnatal periods.
- Bolstering the quality of care is an essential checkpoint because efforts to increase utilization will rely on the same health systems where vulnerable populations are presently accessing care.
- With greater attention focused on tracking country-level progress, more data will hopefully become available to effectively monitor changes in coverage for key maternal and neonatal interventions. As these parameters or inputs are better defined, modeling can contribute to the body of knowledge by offering an informed approach to examine quality of care gaps so that better strategies can be developed to improve health among mothers and their children seeking care in this context.
Citation: Chou VB, Walker N, Kanyangarara M (2019) Estimating the global impact of poor quality of care on maternal and neonatal outcomes in 81 low- and middle-income countries: A modeling study. PLoS Med 16(12): e1002990. https://doi.org/10.1371/journal.pmed.1002990
Academic Editor: Lars Åke Persson, London School of Hygiene and Tropical Medicine, UNITED KINGDOM
Received: April 7, 2019; Accepted: November 21, 2019; Published: December 18, 2019
Copyright: © 2019 Chou et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Data Availability: To access study data including mortality, intervention effectiveness, and coverage estimates, download the Lives Saved Tool module (https://www.livessavedtool.org/listspectrum) as part of the SPECTRUM suite. With installation of this open-access software package, default data are included, which were used as the model inputs for this analysis. Indicators applied as LiST inputs are drawn from country-specific datasets (e.g., Demographic and Health Surveys [DHS] and Multiple Indicator Cluster Surveys [MICS]), which are publicly available but provided with any standard download on a Windows-based computer.
Funding: This work was partially supported by the Bill & Melinda Gates Foundation (http://www.gatesfoundation.org/) through grant OPP1084423 (NW) and grant OPP1161450 (subaward from Harvard T.H. Chan School of Public Health). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
Competing interests: The authors have declared that no competing interests exist.
Abbreviations: AMTSL, active management of the third stage of labor; ANC4+, proportion of women who attended four or more antenatal visits; DHS, Demographic and Health Surveys; HFD, percentage of births delivered in a health facility; IMPAC, Integrated Management of Pregnancy and Childbirth; IPTp, Intermittent preventive treatment in pregnancy; LiST, Lives Saved Tool; LMIC, low- and middle-income country; MICS, Multiple Indicator Cluster Surveys; MMR, maternal mortality ratio; MNCH, maternal, neonatal, and child health; ORS, oral rehydration solution; pPRoM, preterm premature rupture of the membranes; RDT, rapid diagnostic test; RPR, rapid plasma reagin; SARA, Service Availability and Readiness Assessment; SDG, Sustainable Development Goal; SGA, small for gestational age; SPA, Service Provision Assessment; VDRL, venereal disease research laboratory; WHO, World Health Organization
Achieving targets for the Sustainable Development Goals (SDGs) for 2030 will require not only rapid accelerated change but also robust linkages established across many sectors. The central importance of a high-quality, well-functioning, and resilient healthcare system to deliver proven interventions was championed over a decade ago by the World Health Organization (WHO) , and the urgent need for this strong foundation has become increasingly apparent as information about coverage of available interventions is systematically tracked  and trends across and within countries are documented . Gaps are apparent, as health outcomes have not improved despite encouraging signs such as a greater proportion of births occurring in health facilities . Simply knowing what should be done to reduce maternal  and neonatal mortality  and to prevent stillbirths  in low-resource settings is not sufficient when countries face the concomitant challenges of both providing those effective interventions at scale and maintaining a tolerable threshold for the quality of medical care being provided.
Health systems strengthening and the focus on an integrated approach coincides with increasing awareness that quality of care is a complex, multifactorial, but critical driver that can catalyze progress or mire potential success . The Lancet Global Health Commission on High Quality Health Systems, which called for a better understanding of the dimension of quality for health systems in resource-limited settings , has contributed growing evidence that merely accessing or reaching the doorstep of a healthcare system does not equate to or ensure receipt of high-quality care [10,11].
WHO’s vision for pregnant women and newborns centers on provision of established life-saving interventions through high-quality and timely care to effectively reduce leading causes of mortality and morbidity worldwide . Quality of care can be broadly conceptualized as structure including material resources or other structural inputs, processes or the activities undertaken by patient and/or provider, and outcomes defined as change(s) in resulting health status . In low-resource settings, where fragmented health programs face shortfalls in drugs and supplies, functional equipment, and trained personnel, ensuring adequate quality of care within health systems is a key stepping stone if the ultimate benefits of achieving universal health coverage are to be successfully maximized .
To this end, mathematical models have served as a valuable platform, because outcomes can be mapped into the future and measurable gains can be quantified for evaluation or strategic planning purposes . Projecting the potential impact of interventions was first presented by the Bellagio Child Survival Group  and this framework was further developed and expanded into the subsequent Lives Saved Tool (LiST) model . This evidence-based approach has traditionally focused on the “outcomes to impact” linkage (Fig 1), with LiST extrapolating the impact of scaling up coverage of key maternal, neonatal, and child health (MNCH) interventions with baseline levels typically derived from household surveys or country-level reporting.
The conceptual model of the LiST depicted with applicable data sources. LiST, Lives Saved Tool.
The aim of this study is to estimate the global impact of poor quality of care in countries where disease burdens remain high and elevated morbidity and mortality persist. To achieve this aim, we conducted a multicountry analysis with a novel application combining elements from health facility assessments with utilization data to first examine intervention coverage. This insight is then used to estimate impact (i.e., improved survival) if points of contact made with the existing healthcare system during pregnancy and labor were no longer serving as empty placeholders. Our modeling approach explores the global consequences if the quality gap could be closed so that “effective coverage,” or the “fraction of potential health gain that is actually delivered to the population through the health system” , could be expanded during the period 2016–2020 to merely represent those already seeking care in each country.
Study design and sample
The LiST, a linear and deterministic model , was used to estimate the impact that improved quality of care could have for MNCH. The study protocol and analysis plan were not prespecified and were not available prior to this study. The RECORD statement is available in S1 RECORD Checklist as a checklist, but ethics approval was not required for this analysis. This modeling exercise focused on secondary data analysis of large, cross-sectional, publicly available, and nationally representative survey datasets, which do not require ethical review for analysis. The LiST model’s primary determinant is intervention coverage, which is holistically defined as, “the proportion of a population in need of a health intervention that actually receives it” , and increases in population-level intervention coverage are used to calculate impact, which is quantified as a reduction in the number of deaths or other adverse outcomes (e.g., preterm birth). The model is routinely revised to incorporate updated country-specific information about intervention coverage from household surveys (e.g., Demographic and Health Surveys [DHS], Multiple Indicator Cluster Survey [MICS]) and estimates of cause-specific intervention effectiveness . Default data sources for standard model parameters are presented in S1 Table. LiST module from Version 5.67, released May 10, 2018, as part of the Spectrum suite, was used for this analysis.
Country-specific models for a sample of 81 low- and middle-income countries (LMICs) representing the majority of the global burden being tracked by Countdown to 2030 were created (see S2 Table), with most contextual indicators about population health status and intervention coverage drawn from national level surveys. Of the global burden, this subset of countries represents an estimated 89% of the neonatal deaths, 96% of the maternal deaths, and 87% of the stillbirths occurring worldwide [20,21].
Using a linking approach, nationally representative data for the study period from 2007 to 2015 were collated from health facility assessments (i.e., Service Provision Assessment [SPA] and Service Availability and Readiness Assessment [SARA] surveys) and then combined with data from household surveys (e.g., DHS and MICS). Linked surveys were separated by an interval of ±2 years or less, and countries with linked datasets available (n = 17) are shown in Table 1.
A full description of the linking approach used to derive estimates of population-based intervention coverage has been published [22,23], but in summary, uniform indicator definitions were developed to specify a minimum set of structural inputs for particular antenatal, childbirth, or postnatal care interventions (n = 19). This subset of 19 life-saving maternal and neonatal health interventions was selected because the availability of key components (e.g., required staff and guidelines, equipment, medicines, and commodities) was assessed during SPA or SARA data collection and indicators could be constructed for readiness as a proxy for the quality of care. These interventions were drawn from the complete listing of 60+ interventions available in the module (see S1 Text documentation), which are organized across the continuum of care by timing of provision: from antenatal care, childbirth care, to postnatal preventive or curative care. One single intervention may impact one of more causes of death (e.g., neonatal sepsis and neonatal tetanus) or influence one or more outcomes (e.g., maternal death and stillbirths). One outcome may be impacted by more than one intervention, but the overall structure of the cause-specific mortality model precludes errors attributable to double counting.
Basic elements assumed to be required for adequate delivery of each selected health intervention are presented in Table 2. For example, the availability of a functional newborn bag and mask, staff trained in neonatal resuscitation, and Integrated Management of Pregnancy and Childbirth (IMPAC) guidelines are assumed to be the minimum required for the provision of neonatal resuscitation as a life-saving intervention. “Baseline” levels of coverage were then calculated by multiplying the availability of these essential components as a measure of readiness by the proportion of pregnant women seeking care or births occurring at this level within each health facility stratum. Accounting for both utilization and readiness with this approach provides an approximation of how high intervention coverage could theoretically be, given the prevailing restrictions of missing components or low levels of care-seeking. These analyses were conducted using STATA 14.2 (College Station, TX).
Scenarios for scaling up
Baseline levels for intervention coverage were calculated and applied in countries with a linked dataset, and the median for each intervention was calculated based upon this sample. For countries without a linked dataset, the sample median was applied to serve as a proxy for the starting level in 2016. The 25th and 75th percentile values were also calculated, and sensitivity analyses were conducted to examine these thresholds as lower and upper bounds, respectively. For all 81 countries included in the analysis, a country-specific national target or hypothetical “cap” was set for 2020 based upon reported access or utilization (see S1 Table for the most recent survey source). The proportion of women who attended four or more antenatal visits (ANC4+) according to the last population-based household survey was considered a standard measure of the percent of pregnant women who “should have” properly received evidence-based antenatal interventions during an antenatal visit. Similarly, the percentage of births delivered in a health facility (HFD) was considered the endpoint for modeling intervention scale-up as improvements in the quality of childbirth interventions based upon the conservative assumption that every individual who sought care “should have” received care of adequate quality during the intrapartum period. Annual trends starting from 2016 were produced by linearly interpolating the level of intervention coverage from baseline (which is country specific in countries with a linked dataset or the sample median in countries without a linked dataset) to reach the national level of current utilization as the ideal in 2020.
For all other interventions included in the LiST model that were not relevant for this “quality of care improvement” scenario, coverage was held constant and did not increase, so these interventions did not contribute to reductions in mortality or morbidity. Examples include childhood immunizations, oral rehydration solution (ORS), and ownership of insecticide-treated bednets. Fig 2 presents the impact pathways for each set of grouped interventions, and the key outcomes of interest were changes in estimated rates for maternal and neonatal mortality and stillbirths, as well as the specific contribution of individual interventions to the total number of lives saved. Health impact was quantified as the number of “lives saved” in each country-specific model and all results were ultimately presented in aggregate as a global total representing the study period to 2020.
Interventions provided during antenatal, childbirth, and postnatal care are shown with associated risk factors and mortality outcomes. AMTSL, active management of the third stage of labor; IPTp, Intermittent preventive treatment in pregnancy; LiST, Lives Saved Tool; pPRoM, preterm premature rupture of the membranes; SGA, small for gestational age.
Impact on mortality
Our analysis focused on modeling “what if” well-functioning health systems could ensure high-quality care to merely provide a subset of 19 evidence-based maternal and neonatal interventions to those who are currently accessing or utilizing the existing service platforms. Present levels of utilization were found to be low overall, with an average of 60% (6%–96%, minimum–maximum) of women reportedly attending four or more antenatal visits and 66% (9%–99%, minimum–maximum) of deliveries occurring in a health facility, based upon national reports. Despite incorporating these low levels of utilization as the modest targets for 2020, we estimated a substantial reduction in the aggregate global sum of maternal deaths (28% decrease), neonatal deaths (28% decrease), and stillbirths (22% decrease) in the final year compared to a scenario without any change or improvement in the quality of care. In our representative sample of 81 high-burden countries, a total of 86,000 (range, 77,800–92,400) maternal, 0.67 million (range, 0.59 million–0.75 million) neonatal lives could be saved and 0.52 million (range, 0.48 million–0.55 million) stillbirths could be prevented in 2020 if populations in LMIC settings maintained the current levels of health system use but the standard for quality of clinical care was raised (Fig 3).
The total number of maternal (tan) and neonatal (orange) lives saved and stillbirths prevented (green) organized by the timing of delivery for the evidence-based intervention. LMIC, low- and middle-income country.
Ensuring a minimum threshold of quality for this set of MNCH interventions would also produce declines in estimated mortality rates. On average, maternal mortality ratio (MMR) would drop 32%, neonatal mortality rate would decrease 31%, and the stillbirth rate would drop 21% according to the modeled projections for these 81 countries (Fig 4). For maternal mortality, the change in MMR was minimal for the two countries of Somalia and South Sudan, where the estimated reductions were −4% and −6%, respectively. Accordingly, the country-specific targets set for 2020 based upon current utilization were also the lowest for these two countries (Somalia: 6% ANC4+, 9% HFD; South Sudan: 17% ANC4+, 12% HFD).
Bars represent the 25th, 50th (middle), and 75th percentiles for the percent change in MMR, neonatal mortality rate, and stillbirth rate. The outliers include Somalia and South Sudan, which were estimated to have very modest reductions in MMR. LMIC, low- and middle-income country; MMR, maternal mortality ratio.
Contribution by intervention
Of the life-saving interventions that were examined, improvements to close the quality gap for key interventions provided at or around the critical time of childbirth would produce the greatest benefit. Interventions during this period accounted for 64% of the impact overall (87% of prevented stillbirths, 47% of neonatal deaths, and 67% of maternal deaths), which exceeded benefits quantified for the antenatal or postnatal periods.
In this study, we created linear and deterministic models to examine the global impact of low-quality or inadequate care in a representative sample of 81 LMICs with recent national-level data. We quantified potential declines in mortality and found that gains would be sizeable if baseline levels of a focused package of life-saving interventions were set to reach higher levels, with effective coverage equivalent to currently reported utilization. Our analysis used a novel linking approach to combine health facility datasets, which provide an assessment of readiness, with household surveys, which report on patterns of utilization around the same time period. This ecological approach is advantageous to estimate baseline coverage for important interventions that cannot be tracked through the standard approach, which relies on participant self-reports in household surveys. This set of country-specific models, which represents a large majority of the global burden, found that scale-up of high-quality care for selected MNCH interventions would be invaluable.
Strengths and limitations
The strengths of our study are based upon the analysis of a large, population-based, representative sample of countries (n = 81) where most of the maternal and neonatal deaths and stillbirths are occurring. Using a mathematical model, our quantification of the benefits of eliminating poor-quality care is based upon recent country-level data collected with health facility and household surveys. The estimates of health impact presented here focused exclusively on mothers, newborns, and stillbirths as the direct beneficiaries of the life-saving interventions we modeled, and we did not account for any of the broader impact if adverse consequences known to be associated with these fatalities [24–26] are averted. Although processes of care were not explicitly examined in this work, coverage of practices such as early initiation or exclusive breastfeeding, for example, may increase if better trained medical staff or enhanced supervision is available, as the health workforce is acknowledged to be a critical pillar of quality improvement . Lastly, our scope did not include all MNCH interventions but was selectively narrow to only certain antenatal, childbirth, or postnatal interventions that could be influenced by improvements in structural inputs in a health facility context. Because the types of indirect effects mentioned above may not have been fully captured, our totals are likely to be underestimates of the true global and societal rewards if well-equipped facilities with skilled health workers provided high-quality care at the right time on a population level.
Although standardized household surveys can assess coverage for a limited set of MNCH interventions , some bias is associated with self-report , and not all interventions can be tracked with this approach. Furthermore, coverage indicators for some newborn interventions presently lack consensus definitions. Standard metrics have yet to be developed and need to be validated before measurement efforts can be implemented at scale and global progress of newborn interventions can be effectively monitored . Acknowledging that gaps such as these have yet to be addressed and tracking inputs for improving quality of care is complex, our approach presents an accessible snapshot of known, evidence-based interventions that span across the continuum of care. As is generally the case, this type of global analysis offers a valuable alternative because conducting an evaluation of the entire operational framework developed for the monitoring and evaluation of each country’s health system  is not feasible.
"Our estimates can only be as valid as the data on which they are based” . The limitations of our approach center around inputs for the model, which include assumptions about the efficacy of interventions and MNCH indicators from household surveys. As a dynamic representation of current knowledge about MNCH best practices, the LiST model relies on up-to-date Cochrane reviews, meta-analyses, or Delphi estimation to reflect how effective an intervention would be to reduce cause-specific mortality. The lingering uncertainty about antenatal corticosteroid use in low-resource settings, for example , highlights the inherent vulnerability of using an evidence-based platform, because it must change and evolve, by definition. As new findings surface or recommendations change, assumptions need to be adjusted, and projected estimates may be subject to change as a result.
Another caveat is related to the availability of country-specific data collected through population-based surveys. Typically conducted in rounds, DHS and MICS provide national-level data every 3–5 years, with the two survey programs applying different reference periods for calculating MNCH coverage indicators . Our cross-sectional approach uniformly designated 2016 as the baseline year to standardize all models, with each country-specific model incorporating indicators about health system utilization (i.e., ANC4+ and HFD) from the most recent DHS or MICS dataset available. This means that the period when fieldwork was conducted (i.e., measurement occurred) does vary across the 81 countries. To limit misinterpretation due to this information bias, estimates were presented as global totals for the representative sample in 2020.
These findings underscore the importance of addressing the considerable burden caused by extant poor- or low-quality health services that are currently available and being provided for pregnant women and newborns in LMICs. Potential reductions in maternal and neonatal mortality and stillbirths are substantial if changes can be made to ensure adequate quality for the modest subset of life-saving antenatal, intrapartum, and postnatal interventions included in this analysis. Although the “quality chasm” for maternal, newborn, and child healthcare in these low-resource settings appears daunting , our work highlights the first benchmark of preliminary gains that could be anticipated if the standards of quality for clinical care were established as the overarching top priority and health systems were redesigned or strengthened to deliver consistent and high-quality evidence-based care, first and foremost, to those already seeking care and readily on hand.
Our modeling presents a conservative scenario, with the level of quality being raised to only match currently reported patterns of utilization. In fact, the benefits reaped at an individual or global level could be far greater if improved quality of care influences care-seeking patterns and subsequently drives greater demand or increases utilization in the low-resource environment of LMICs. Outreach efforts, demand creation, or expansion to provide a wider range of advanced medical services are valuable initiatives that must be incorporated as stepping-stones when universal healthcare and improving health for all population subgroups are milestones on the horizon. Although a two-pronged approach dually targeting quality of care and utilization holds the most promise for driving synergistic change, this analysis shows that merely providing a core package of MNCH services during existing health system contacts would be meaningful.
An inefficient healthcare system may be criticized as being frustratingly inadequate or cumbersome, but poor-quality care can be dangerously harmful at its worst if timely and skilled medical care is not being properly provided during the appropriate window or opportunity [27,31]. Population health suffers, and indicators do not markedly improve or may even worsen among those being served despite investment in and expenditures of precious limited resources. Analyses such as the one we have presented do not offer an exhaustive roadmap to guide all future action but highlight which next steps are most urgently needed or which priorities should be prominent. As more data become widely available from health facility surveys or accessible through global monitoring efforts, contextual factors and dominant patterns may be better understood at the national or subnational levels, where significant disparities may exist for both utilization  and quality of healthcare components . Clinical reporting and civil registration systems may be developed or bolstered to serve as consistent, complete, and coordinated data sources for frequent tracking at a lower level . Building and strengthening these components of a robust health system are therefore not optional features but the required cornerstones to ensure that timely progress can be made toward the SDG ideal of “good health and well-being” universally for all the world’s people.
S1 Table. LiST parameters and data sources (Version 5.67).
LiST, Lives Saved Tool.
S2 Table. Listing of countries included in the analysis.
We would like to thank Dr. Allisyn Moran for her thoughtful comments during initial discussions and Dr. Andreea Creanga for her input about clinical components required for service delivery.
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