Citation: Rosen S, Fox MP, Larson BA, Sow PS, Ehrenkranz PD, Venter F, et al. (2016) Accelerating the Uptake and Timing of Antiretroviral Therapy Initiation in Sub-Saharan Africa: An Operations Research Agenda. PLoS Med 13(8): e1002106. https://doi.org/10.1371/journal.pmed.1002106
Published: August 9, 2016
Copyright: © 2016 Rosen et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Funding: Funding for the work presented here was provided by the Bill & Melinda Gates Foundation under the terms of OPP1136158 to Boston University. The funders participated in the Technical Consultation reported here and are co-authors of the manuscript. The funders had no separate role, beyond that of other participants and authors, in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
Competing interests: I have read the journal's policy and the authors of this manuscript have the following competing interests: PDE and PSS are employees of the Bill & Melinda Gates Foundation, which funded this work. FV sits on antiretroviral initiation guideline committees, both local and international. FV has accepted speaking honoraria from multiple manufacturers of antiretrovirals and is on several of their advisory boards. FV is on the editorial board of PLOS ONE and on the PLOS Human Research Advisory Group.
Abbreviations: ART, antiretroviral therapy; ARV, antiretroviral; CrAg, cryptococcal antigen; IRIS, immune reconstitution inflammatory syndrome; MATI, Models for Accelerating Treatment Initiation; TB, tuberculosis; WHO, World Health Organization
Provenance: Not commissioned; externally peer reviewed
- Under 2015 World Health Organization guidelines calling for antiretroviral therapy (ART) for all HIV-infected persons (the “treat all” approach), millions of new patients will be eligible to initiate ART, but existing procedures for treatment initiation are cumbersome and slow, contributing to high loss to follow-up before antiretroviral medications are dispensed. Simpler, more efficient, accelerated algorithms for ART initiation are needed.
- The Models for Accelerating Treatment Initiation (MATI) technical consultation developed an operations research agenda to build an evidence base for accelerating ART initiation. It focused on the operational question of how to start ART, with “how” encompassing timing and speed, required laboratory tests and the technologies for performing them, where to initiate (in the clinic, community, or home), the quantity and content of counseling and education needed, and the roles of different cadres of service providers, including facility- and community-based healthcare workers.
- Six priority research questions for optimizing the initiation process were identified. The highest priority is to evaluate whether a simplified clinical algorithm in patients who have tested positive for HIV can safely identify patients who should and should not start ART immediately without awaiting further laboratory test results, followed by determining the optimal speed of initiation and how to streamline clinic operations to make initiation more efficient.
- Proposed standardized outcomes to measure in research on models of treatment initiation include ART initiation within 28 days of first HIV-related clinic visit, six-month retention in care (clinic visit within 90 days of the expected six-month visit after initiation), and early viral suppression (suppressed viral load within 28 days of the expected first routine viral load test).
In 2015, the World Health Organization (WHO) recommended initiating lifelong antiretroviral therapy (ART) for all patients testing positive for HIV, regardless of CD4 cell count . WHO cited three anticipated benefits from this “treat all” approach (also called “test and start” or “test and treat”): reduced morbidity among HIV-infected patients, reduced risk of transmission from HIV-infected individuals to their partners, and “increases in ART uptake and linkage to care, reduction in the time between HIV diagnosis and ART initiation regardless of baseline CD4 cell count and an increase in the median CD4 value at ART initiation.” A recent analysis suggests that future reductions in HIV-related mortality in sub-Saharan Africa will derive largely from this last benefit, rather than from the first two .
Although for budgetary and other practical reasons many low- and middle-income countries continue to apply a CD4 threshold to determine ART eligibility, it is clear that the trend is toward offering treatment to all those diagnosed with HIV. As this happens, the importance of “pre-ART care,” defined as care in the interval between HIV diagnosis and ART initiation, will diminish, along with the well-documented challenge of retaining patients in pre-ART care [3,4]. One of the challenges that will replace it is that of initiating newly diagnosed individuals on ART as efficiently as possible, while ensuring that patient autonomy, welfare, and retention on ART are not jeopardized by the initiation process.
Studies from throughout sub-Saharan African continue to document high losses of treatment-eligible patients from care before they receive their first dose of antiretrovirals (ARVs), due to a wide range of facility- and patient-level barriers to initiation . Multiple required visits, long waiting times, stock outs of supplies, staff absences, and poor communication between staff and patients all deter treatment initiation [6–9]. Many of these barriers will remain under a treat-all policy that does not also solve the problem of linking patients to care or initiating them on ART efficiently. Patients tested in the community will continue to require referral to a facility providing ART. The need to screen for and treat tuberculosis (TB)  and cryptococcal infection [11,12] before starting ART will also remain. Retention of patients on ART in the months after treatment initiation, moreover, may depend in part on the manner of treatment initiation. Simpler, more efficient, and faster algorithms for ART initiation will be needed if the treat-all approach is to realize the benefits expected.
To begin to develop such algorithms, the Models for Accelerating Treatment Initiation (MATI) technical consultation was held in October 2015 (see S1 Text for the meeting agenda). The MATI consulation was premised on the observation that while many studies have evaluated what to start (regimens) and when to start (eligibility), few have tackled the operational question of how to start ART, with “how” encompassing issues of timing and speed, required laboratory tests and the technologies for performing them, where to initiate, the quantity and content of counseling and education needed, and the roles of different cadres of service providers.
The MATI consultation developed a list of priority operations research questions on how to optimize algorithms for treatment initiation in sub-Saharan Africa, with the goal of maximizing the number of patients who can be initiated on ART given available financial, infrastructural, and human resources and without jeopardizing treatment outcomes. Box 1 lists some of the topics that were addressed. Here we present the six research priorities that were identified and briefly discuss each one. We note that these priorities and the outcomes defined in the next section pertain to general adult populations. Pregnant and postpartum women, children and adolescents, and populations facing specific obstacles in accessing care (e.g., migrants, sex workers) may call for different approaches than those suggested here.
Box 1. Characteristics of Treatment Initiation Addressed by the MATI Technical Consultation
Patient populations: Who will be starting ART in the future?
- Many patients will be diagnosed with HIV for the first time
- Some patients will have been monitored in pre-ART care but were not previously eligible for ART
- Many patients will have been previously diagnosed and lost from care before starting ART
- An increasing number of patients will be re-initiators—patients who received ARVs at some time in the past but then stopped treatment
Timing and speed of treatment initiation: Once a patient has been diagnosed, how quickly can treatment be started without risking starting “too fast” and jeopardizing patient welfare or post-initiation outcomes and retention?
- Number of clinic visits required
- Time interval between visits and from start to finish
Minimum clinical information required: What do clinicians need to know before they prescribe ARVs, and what is the most efficient way to generate this information?
- Risk of TB
- Risk of cryptococcal meningitis
- Other immune reconstitution inflammatory syndrome (IRIS) risks
- Information from physical examination
- Results of blood tests to select ARV regimen (e.g., creatinine clearance)
Minimum counseling and education required: What are the optimal number, duration, timing, staff cadre, and content of nonclinical interactions to ensure that patients are able and willing to adhere to ART?
- HIV/ART/adherence education
- Individual and/or group counseling
- Optimal staff cadre providing services (nurses, counselors, other)
- Counseling before or after initiating medications
Location of ART initiation: Can ART be initiated successfully in nonclinical locations?
- HIV testing and ART initiation on-site (at a clinic)
- HIV testing off-site and referral to a clinic for initiation
- HIV testing and initiation off-site (e.g., home-based or other community locations)
- Role of community volunteers (e.g., community health workers) and clinic-based professional staff in supporting initiation in community and/or clinic settings
- Effect of location of initiation on early retention on ART
Patient behavior and decision-making: How can acceptability of ART initiation be improved?
- Known and new patient barriers to enrollment and initiation
- Effect of model of ART initiation on patient uptake of ART (will more patients accept ART if initiation is easier?)
- Importance of targeting initiation models to different patient populations
- Care for patients who choose not to start ART (either not now or not ever)
Supply side: What do health systems need to have and do for accelerated initiation?
- Role of health system context in choosing model(s) of treatment initiation
- Reducing known barriers to initiation created by healthcare providers, such as long waiting times and patient record systems that inhibit effective follow-up
- Infrastructural, procurement, human resource, and other provider requirements and bottlenecks for accelerated initiation
Demand side: How many more patients will seek ART initiation?
- Pace of adoption of “test and start” at the country level
- Proportion of HIV-infected populations that will remain undiagnosed or decline treatment
- Capacity of existing models and/or need for new model(s)
Measuring success and data requirements: How should we evaluate different models of ART initiation?
- Outcomes (definitions for ART initiation, viral suppression, early retention on ART)
- Provider costs and cost-effectiveness
- Patient costs and benefits
Question 1: What does it take to start ART under current practices, and how will this change when the 2015 WHO guidelines are adopted, as measured by number of clinic visits needed, duration of process from start to end, laboratory tests and other clinical procedures required, counseling and education required, and resources utilized?
Question 1 asks for a baseline of actual practice to provide a better understanding of how treatment initiation is currently being conducted. There is very little published evidence on the practical details of the process and the extent to which it varies by facility, setting, or country. Without a robust baseline evidence base, it is challenging to identify opportunities for making improvements.
Answering question 1 in a comprehensive way will require data collection in multiple countries and settings. Fortunately, most of the data required can be generated relatively quickly, by administering detailed cross-sectional questionnaires on procedures and resources to facility-level staff. A medical record review to estimate actual numbers of clinic visits, services provided, and duration from start to finish will also be needed in most settings.
Question 2: Can a simplified clinical algorithm comprising a symptom report, medical history, readiness assessment, and brief physical exam in HIV-positive patients reliably identify patients who should and should not start ART immediately (during the same clinic visit), and will such an algorithm increase the proportion of patients who initiate ART and achieve viral suppression, compared to standard care?
Question 2 was considered the highest priority research question by MATI consultation participants. The diagram in Fig 1 illustrates the new algorithm that the MATI consultation recommended should be evaluated. It is premised on the expectation that once there is no longer a CD4 count threshold in place, a large proportion of those who test HIV-positive will be clinically eligible for immediate initiation, and that we should not delay starting treatment for the majority of patients who are ready to start immediately in order to prevent starting too quickly for the minority who are not. Question 2 posits that an algorithm based on a simple symptom report, medical history, treatment readiness assessment, and limited physical exam in patients who have tested positive for HIV will identify patients who should and should not start ART immediately with sufficient accuracy to improve overall health outcomes. The algorithm is based on the hypothesis that the benefits gained from immediate initiation, in terms of reduced loss to follow-up, exceed any risks from adverse responses to ART that may also result from immediate initiation.
Diagram showing the steps that could be included in an algorithm to evaluate whether HIV-positive patients are eligible for immediate ART initiation or instead require additional care or services before medications are dispensed. The MATI consultation recommended that this algorithm be evaluated in research studies. CrAg, cryptococcal antigen.
Under the algorithm, HIV-positive patients who have acceptable results for the symptom report, medical history, readiness assessment, and physical exam can be deemed clinically eligible to be dispensed ARVs on the same day, without waiting for other laboratory test results or other steps. Baseline tests such as CD4 count, creatinine, and/or other blood tests, and cryptococcal antigen (CrAg) screening where indicated, could still be done but would not delay ART initiation. Nonclinical steps, such as counseling and education about ART adherence, could be done on the same day and/or at follow-up visits, without losing the value of these activities.
Initiating ART in patients with underlying conditions such as TB or cryptococcal infection who were not screened out by the simplified algorithm would increase the risk of IRIS or death. For TB, the algorithm symptom screen includes the standard TB symptoms already used to identify TB suspects in most settings, such that the risk of TB IRIS under the new algorithm would likely not change relative to current practice. WHO guidelines recommend isoniazid preventive therapy  to reduce TB mortality risks in asymptomatic HIV patients with low CD4 counts [14,15] and co-trimoxazole prophylaxis for patients with CD4 counts below 350 cells/μl ; both isoniazid preventive therapy and co-trimoxazole prophylaxis could augment the simplified algorithm. Cryptococcal infection is more challenging; in countries with routine CrAg screening, a patient with a positive CrAg test would need to be contacted promptly and receive appropriate care.
Whether the benefits of the simplified algorithm exceed the risks is a question that should be evaluated empirically. The research to answer question 2 will likely entail randomized trials to generate an evidence base that represents a range of settings and populations. While such trials will take some time to launch, if high-volume study sites are chosen, enrollment and follow-up can be completed quickly, as outcomes (uptake of ART and retention and attrition in the first six months after initiation) can be assessed very soon after study enrollment. Evaluations of programs that offer immediate ART to HIV-positive pregnant women [17,18] may also provide clues about how a simplified algorithm like that in Fig 1 will perform in the general adult population.
Question 3: What is the optimal timing and speed of initiation, including the number of clinic visits and the duration of the process from start to finish, as measured by early ART outcomes and cost-effectiveness?
Question 3 addresses how fast is “fast enough” or “too fast” for the ART initiation process. Options include single-visit initiation (also called “same day” initiation), in which ARVs are dispensed during a patient’s first HIV-related clinic visit, which might occur on the same day as HIV diagnosis; a two-visit process that allows time for laboratory tests and personal acceptance of the need for treatment in between the two visits; or an initiation process that includes more than two visits, including the status quo, which typically requires anywhere from three to six visits. The optimal number of days between visits is also relevant to question 3: a three-visit process in which all visits are completed in one week may have different consequences for patients than the same number of visits spread over six or eight weeks.
Two new randomized trials [19,20] and a single-arm program evaluation , while taking very different approaches, all found that accelerating the process of ART initiation resulted in very high uptake of ART and, in the case of the trials, significantly better health outcomes for patients. Other relevant studies are underway, and it is likely that a wide range of innovations aimed at speeding up treatment initiation are being implemented in nonresearch contexts. If these experiments are evaluated properly, they may also contribute to the evidence base. A challenge in considering alternative approaches is heterogeneity in the starting point for evaluation: some studies begin with the HIV test, other studies count only clinic visits made once a patient has enrolled in care, and still others start only when treatment eligibility has been determined.
Additional questions related to speed and timing include the following: (1) Is more than one adherence education session needed to generate good patient outcomes, or is one session enough? (2) Do patients themselves prefer having a single visit or multiple visits? (3) Does the speed or timing of visits prior to treatment initiation affect outcomes after initiation?
These questions are likely to have different answers for different patient populations, health systems, and settings. The pace of guideline changes and the many programmatic innovations already underway may overtake any randomized controlled trials that are launched now, arguing for investment in rigorous evaluations of initiatives already underway, rather than the development of new trials.
Question 4: What changes to clinic management, capacity, and resources are needed to support accelerated ART initiation, and particularly same-day initiation?
Once effective approaches to accelerating treatment initiation are identified, adjustments to health clinic practices and capacity will be needed to implement them in routine practice and at scale. Changes may be necessary in staff training, responsibilities, schedules, and performance management; patient-to-provider ratios; clinic space allocation; the flow of patients through the clinic; inventory storage and tracking; and data management. The studies of accelerated initiation cited above all provide some clues as to what kinds of changes may be needed. Resource constraints—limits in staff time and motivation, consultation rooms, patient waiting areas, and even stationery for record keeping—will be a concern in many settings. Any effort to accelerate or improve ART initiation is likely to require better data management than is currently in place in most clinics, so that patients can be tracked accurately and promptly, requiring investments in data systems as well as human and infrastructural resources.
Question 4 is an operational question that will likely be answered through an iterative empirical approach as governments and treatment support programs adjust to new recommendations on accelerated treatment initiation and absorb the larger numbers of eligible patients under the new WHO guidelines. From a research perspective, much of this work will fall within the domain of those who evaluate health system performance or undertake quality improvement assessment, with quantified patient outcomes as the desired endpoints.
Question 5: Is initiation of ART outside of clinics (community- or home-based ART initiation) safe, effective, and cost-effective?
Moving HIV-related service delivery from clinics to other locations is a major goal of WHO recommendations and is the focus of a great deal of recent research. While there is a long history of community-based HIV testing, and increasing evidence about managing stable ART patients outside the clinic, the actual initiation of ART in nonclinical settings or in patients’ homes is a relatively new topic .
The potential benefits of initiating treatment in community- or home-based settings include increased access, reduced patient costs, reduced crowding in clinics, and better uptake of ART. The potential costs, or harms, include poorer retention in care after initiation for patients who never get “established” in an ART program, more adverse events related to the lack of clinical attention to the patient, and the program costs of service delivery in other locations. Patient density, distances to facilities, and the health worker cadre employed to provide the services will have a large effect on costs. It is unclear whether existing human resources are sufficient in numbers and training to supervise home-based initiation, even if there is reduced patient volume at clinic facilities. It is also important that data systems reliably capture non-clinic-based services, so that patients can continue to be monitored by clinical providers.
Research in a wide range of countries and populations, using different service delivery approaches, will be needed to determine whether the benefits exceed the costs and are sustainable outside research settings. Studies are currently being launched , and there are likely to be numerous opportunities to evaluate programs already underway. A mathematical cost-effectiveness model could be developed that would help identify the conditions under which community- or home-based service delivery programs are likely to be cost-effective and affordable.
Question 6: Why do some patients not start ART when advised, and which interventions will be effective in changing behavior to increase and accelerate ART uptake?
The first five questions on the research agenda address the supply side of treatment initiation—how to make the service offered more accessible and efficient. Question 6 turns to the demand side. No matter what is offered by providers, some patients will not start treatment despite being eligible. For those who are never diagnosed or never reach the point of being advised of their eligibility for treatment—populations not addressed in this paper—more effective interventions for HIV testing and linkage to care will be needed . For those who are advised to initiate but decline to do so or delay the process indefinitely, research is needed to understand their reasoning and encourage them to reconsider. It is unclear whether and how different models of treatment initiation affect demand for ART uptake. Better, more patient-friendly approaches may overcome nonclinical barriers to uptake, or the reasons that eligible patients do not start treatment may have little to do with real or perceived service delivery barriers . Actual rates of treatment refusal and the duration of delays between eligibility and initiation are largely unknown, both because of the difficulty of studying what patients do not do and because few health systems are able to trace patients between facilities or even over time. As with much research on the HIV cascade of care, a universal patient identifier that allows tracing of patients would greatly benefit research on how to accelerate ART initiation.
Research Outcomes for Evaluations of ART Initiation
A major obstacle to interpreting and synthesizing existing research on ART initiation is the heterogeneity in outcomes reported. The MATI consultation participants thus also proposed a standard set of primary and secondary outcomes for studies aimed at accelerating or increasing uptake of ART initiation. While the focus of these studies is ART uptake, early outcomes on treatment were also considered important and may be affected by the model of treatment initiation. Whenever possible, studies of ART initiation should start with HIV diagnosis and follow patients through a minimum of six months after treatment initiation (or the point at which treatment should have been initiated). Intermediate endpoints, such as linkage to care or determination of treatment eligibility, remain important, but on their own are not sufficient to evaluate the effectiveness of a new model of service delivery. Proposed primary outcomes are described in detail in Table 1. Secondary outcomes that were identified as potentially important include cost, acceptability, scalability, and generalizability (Table 2).
In each country that adopts the treat-all approach to HIV care, large numbers of new patients will become eligible for ART initiation. Not all of them will volunteer for HIV testing, and many who already know their status will decline to enroll in HIV care. Despite this, we should expect to offer ART initiation to hundreds of thousands, perhaps millions, of new patients, including both newly diagnosed patients and those who previously sought care but were not eligible for ART. Initiating all of these additional patients on treatment without incurring high losses to follow-up will require new approaches to the “how” of treatment initiation. The research agenda proposed here aims to identify and evaluate such approaches, so that countries can adopt appropriate strategies that are backed by evidence of effectiveness and cost-effectiveness and make optimal use of available resources.
Participants in the MATI technical consultation were David Allen (Bill & Melinda Gates Foundation), Ruanne Barnabas (University of Washington), Peter Ehrenkranz (Bill & Melinda Gates Foundation), Nathan Ford (WHO), Matthew Fox (Boston University), Tendani Gaolathe (Princess Marina Hospital, Botswana) Kenneth Gimbel-Sherr (University of Washington), Anna Grimsrud (International AIDS Society), Charles Holmes (Center for Infectious Disease Research in Zambia), Jonathan Kaplan (unaffiliated), Carol Langley (Office of the U.S. Global AIDS Coordinator), Bruce Larson (Boston University), Yukari Manabe (Johns Hopkins University), Ribakare Muhayimpundu (Ministry of Health, Rwanda), John Nkengasong (U.S. Centers for Disease Control and Prevention), Constance Nyamukapa (Imperial College London), Olarotimi Oladoyinbo (U.S. Agency for International Development), Meg Osler (University of Cape Town), Yogan Pillay (National Department of Health, South Africa), Annette Reinisch (The Global Fund), Paul Revill (University of York), Sydney Rosen (Boston University), Lesley Scott (National Health Laboratory Service, South Africa), Zara Shubber (The World Bank), Morten Skovdal (University of Copenhagen), Salif Sow (Bill & Melinda Gates Foundation), Wendy Stevens (National Health Laboratory Service, South Africa), Francois Venter (Wits Reproductive Health and HIV Institute), Peter Vranken (U.S. Centers for Disease Control and Prevention), Juddy Wachira (Moi University), Rhoda Wanyenze (Makerere University), Lynne Wilkinson (Médecins Sans Frontières), and Isaac Zulu (U.S. Centers for Disease Control and Prevention).
Wrote the first draft of the manuscript: SR. Contributed to the writing of the manuscript: SR MPF BL PSS PDE FV YCM JK. Agree with the manuscript’s results and conclusions: SR MPF BL PSS PDE FV YCM JK. All authors have read, and confirm that they meet, ICMJE criteria for authorship.
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