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Scaling Up Global Health Interventions: A Proposed Framework for Success

Summary Points

  • The rise in international aid to fund large-scale global health programs over the last decade has catalyzed interest in improving the science of scale-up.
  • This Essay draws upon key themes in the emerging science of large-scale change in global health to propose a framework for explaining successful scale-up.
  • Success factors for scaling up were identified from interviews with implementation experts and from the published literature.
  • These factors include the following: choosing a simple intervention widely agreed to be valuable, strong leadership and governance, active engagement of a range of implementers and of the target community, tailoring the scale-up approach to the local situation, and incorporating research into implementation.

The adoption of the Millennium Development Goals—coupled with the recent rise in international aid for health—has catalyzed interest in improving the science of scale-up [1]. Global health researchers have realized the need for “a quantitative, scientific framework to guide health-care scale-up in developing countries” [2], a need that has begun to draw the attention of donors [3]. Low- and middle-income countries (LMICs) have begun to study effective ways to deliver proven interventions at scale [4],[5]. Thus, there are promising signs that a “science of large-scale change in global health” is emerging [5].

In this Essay, I draw upon key themes in this emerging science to propose a framework for explaining successful scale-up. This framework is aimed at planners of scale-up processes to use in thinking about strategies for implementing a new program, policy, or intervention to scale.

The term “scaling up” is now widely used in the public health literature, but there is no agreed definition. The term is primarily used, say Mangham and Hanson, to describe “the ambition or process of expanding the coverage of health interventions” [6], a working definition that I use in this article.

Approach to Developing a Framework

The initial ideas for this framework were derived from a 2009 fellowship in global health reporting, which took me to East Africa to report on scaling up insecticide-treated bed nets [7], and drugs for controlling intestinal worms and malaria [8],[9]. I built upon this field reporting by reviewing the relevant literature on scaling up global health interventions in LMICs and by interviewing experts in large-scale change in global health. Text S1 gives further details of the literature review, and Table S1 gives basic demographic information on the interviewees. The interviewees gave written informed consent for anonymous quotations to be published.

Through this approach, I was able to identify a range of reported success factors. My proposed framework places these success factors into six categories, representing different components of the scaling up process:

  • attributes of the specific tool or service being scaled up,
  • attributes of the implementers,
  • the chosen delivery strategy,
  • attributes of the “adopting” community,
  • the socio-political context, and
  • the research context.

These categories were adapted from two previous typologies of scaling up (Box 1).

Box 1. Two Previous Typologies of Scaling Up

Hanson and Colleagues' Typology of Constraints to Scaling Up

Hanson and colleagues proposed that constraints to scaling up operate at five different levels: the community and household, health services delivery, health sector policy and strategic management, public policies cutting across sectors, and environmental and contextual characteristics [10].

Simmons and Shiffman's “Elements of Scaling Up.”

In their work on successfully scaling up reproductive health interventions, Simmons and Shiffman link the reproductive health innovation to “a resource team that promotes it; a user organization expected to adopt the innovation; a strategy to transfer it; and an environment in which the transfer takes place” [11].

My proposed framework differs from earlier scaling up frameworks (e.g., [10],[11]) in two ways. First, it draws upon insights from interviews with scale-up “leaders,” many of whom have led national or global health implementation programs. Second, it incorporates themes emerging from the recent literature (from 2007–2010).

A Proposed Framework for Success

Attributes of the Tool or Service Being Scaled Up


Keeping the intervention simple is widely considered to be a predictor of success [12][14]. The key to “rapid and massive scale-up” of antiretroviral therapy (ART) for people living with HIV in Malawi, say Harries and colleagues, was to “keep the principles and practices of ART delivery as simple as possible” [12]. Billings and colleagues argue that post-abortion care was successfully scaled up in Bolivia and Mexico because it met the criteria for scalability—cost-effectiveness, simplicity, and replicability [13]. A World Bank review of scaling up rural development interventions found that strong efforts at simplifying models or programs were associated with success [14].

One interviewee, who previously led a multilateral health organization, said: “If the intervention is simple, agreed, and there are no dissenting views, scale-up is much more likely to happen.”

Scientifically robust technical policies.

Technical experts who have managed large-scale implementation argue that getting the technical policies scientifically robust before going to scale was crucial for success [15]. For example, before directly observed therapy short course (DOTs), a treatment program for tuberculosis, was scaled up across India, “all technical policies and detailed training modules for every level of staff were written, extensively revised, field tested over a period of several years, finalized, and disseminated widely” [15].

Attributes of the Implementers

Strong leadership and governance.

Case studies in the literature and interviewees' experiences of successful scale-up suggest that strong leadership played an important role [5],[16]. For example, a leadership development program in rural Egypt was associated with an increase in the number of new family planning, prenatal, and postnatal visits and a fall in the maternal mortality rate [16].

Several interviewees pointed to the important role of leadership in Uganda's success in scaling up HIV interventions [17]. The head of an African medical school argued: “Leadership is critical—at national level, regional level. Uganda's success in scale-up was because there was committed leadership to scaling up.”

Engaging local implementers and other stakeholders.

A recurring theme among those I interviewed was the importance of getting buy-in from local implementers and other key stakeholders. The former director of a global health initiative (GHI) highlighted the role of local medical associations: “In neonatal health, if we don't have pediatric associations on board, forget it! For oral rehydration solution, after it was unequivocally demonstrated that it saved lives, the WHO and UNICEF were still doing local trials, randomized controlled trials. These didn't have scientific value but it led to buy-in locally.”

Using both state and non-state actors as implementers.

Non-governmental organizations (NGOs) have played a crucial role in successful scale-up in many settings [5],[6]. A professor of global health said that an NGO in Bangladesh, the Bangladesh Rural Advancement Committee, is now reaching more people with health interventions than the government is reaching. A former director of a GHI discussed how non-governmental recipients of support from the Global Fund to Fight AIDS, Tuberculosis and Malaria have performed better than governmental recipients: “They [NGOs] are more nimble, there may be less corruption, they're quicker off their feet, individuals [in NGOs] are more motivated. From 2005, there are compelling data to show non-governmental recipients did better.”

Interviewees also discussed the role that private providers can play in scaling up, complementing the role of state actors. An expert in health systems reform discussed the importance of removing barriers in both sectors: “For a market solution: are you allowing entry to the market? For the public sector: are you getting tied up in bureaucracy?”

The Chosen Delivery Strategy

Applying diffusion and social network theories.

Rogers identified five factors that are positively associated with the faster diffusion of an innovation (Table 1), five types of adopters (innovators, early adopters, early majority, late majority, and laggards), and five stages in the adoption of a new innovation (awareness, interest, evaluation, trial, and adoption) [18]. Applying such diffusion theories at the right time, in the right place, within a health system has been a factor in the success of several LMIC scale-up programs [5],[19],[20]. McCannon and colleagues argue that successful scale-up programs have also paid attention to “the nature of the social network into which they wish to disseminate new practices,” for example, by considering how people interact and who are the early adopters [5].

Table 1. Factors associated with faster diffusion of an innovation.

Cascade and phased approaches to scale-up.

A national scale-up program for adolescent reproductive health services in health facilities and schools in Tanzania used a “cascade model”—regional trainers supervised district trainers, who in turn trained teachers and health workers [21]. The model succeeded in scaling up the intervention to 75%–100% of intended schools and health facilities in four districts of the country.

A related concept is the notion of going to scale in a phased manner, beginning with a pilot program, followed by step-wise expansion, learning lessons along the way to help refine further expansion [22]. Case studies of successful “phased” scale-up include Thailand's “100% condom” program [23], Guinea's national program to scale up HIV prevention and treatment tools [24], and scale-up of a harm reduction program in Asia [25].

Tailoring scale-up to the local situation, and decentralizing delivery.

A variety of successful scale-up projects tailored implementation to local conditions on the ground and decentralized delivery so that clinics were closer to the target communities [11],[21],[26]. One interviewee, the expert in health systems reform, said: “You must tailor the message to local circumstances. You need some capacity—for example, a toolkit, a support network—to help local decision-makers to interpret a national decree.”

Adopting an integrated approach to scale-up.

While many of the most high profile scale-up campaigns have been vertical in nature (e.g., scaling up insecticide-treated bed nets or ART), a complementary theme in the literature on successful implementation is the value of integrating scale-up activities into existing health systems [24],[27]. Using existing systems can be valuable if rapid scaling up is important, such as using established food and beverage delivery systems to rapidly distribute condoms [27]. HIV and mental health services have been scaled up in LMICs by integrating them into existing health services [26],[28]; similar integration is being planned for cancer services [29].

A related approach is to deliver disease control tools in an integrated manner, such as integrating child survival strategies with immunization [30], linking HIV and tuberculosis services [31], and integrating the control of different neglected tropical diseases [32].

Attributes of the “Adopting” Community

An engaged, “activated” community.

Scaling up by engaging community members or community health workers is well described in the literature. Examples include the Bangladesh Rural Advancement Committee's engagement of itinerant health workers [5] and Pakistan's “Lady Health Workers” program [33]. The active participation of the community in planning, implementing, and monitoring interventions is widely cited as a crucial factor in successful scale-up [11],[21],[24],[34].

A recent multicenter study found that a community-directed intervention strategy was more successful than other delivery strategies for scaling up distribution of ivermectin (an antiparasitic medication), vitamin A supplements, and insecticide-treated bed nets [34]. Recent evaluations of community health worker programs have shown a positive impact on child health [35], while a recent randomized trial in Bangladesh found that scaling up community-based participatory women's groups was associated with reduced neonatal mortality [36]. One interviewee, a former director of a GHI, pointed out that community engagement also means engaging patients: “If patients are not involved, you can't implement. In AIDS, it's the rule. Patients are experienced experts. They've gone through it. They know.”

Socio-Political Context

Political will and national policies.

National, regional, and local policy commitment are cited as important factors in the successful scale-up of breastfeeding in many LMICs (e.g., Bolivia and Madagascar) [37], post-abortion care in Guatemala [38], and DOTs in India [15]. Several interviewees said that political will has played a crucial role in scaling up adult male circumcision in some countries (e.g., Kenya), condom distribution in Thailand, and needle exchange in Iran. “Uganda has not been successful in scale-up of male circumcision,” said the head of an African medical school, “because there's no national policy yet. WHO recommends it should be scaled up. Therefore a policy or guideline must be in place—that's a success factor. Countries with a policy are making greater strides.”

Country ownership.

Several interviewees discussed the importance of country ownership—and of moving away from traditional donor-recipient relationships in which donors dictate the terms—in the success of national scale-up programs in Africa. A former GHI director said that countries that had demonstrated successful scale-up through support from the Global Fund to Fight AIDS, Tuberculosis and Malaria were “special countries where the antipathy for neo-colonial relationships, the national pride, the desire for a new relationship between poor and rich countries overwhelmed the comfort with old, cozy donor relationships.”

Research Context

Incorporating research into implementation (“learning and doing”).

Simmons and Shiffman argue that successful scale-up “requires the systematic use of evidence to guide the process and incorporate new learning” [11]. India's successful program to scale up DOTs adopted such an approach—monitoring was accompanied by timely feedback to implementers. Incorporating research into scale-up is also important for testing the transferability of a successful pilot program to a different setting [39], and for developing a “clearer understanding of the determinants of successful scaling-up” [11].

Several interviewees suggested that scale-up is more likely through synchronous implementation and research, which Peters and colleagues call “learning and doing” [40]. “Using data and experimenting underlies a lot of successful scale-up approaches,” said one interviewee, who leads health service scale-up projects in LMICs. “Mapping constraints, having the flexibility to redesign, learn-do cycling, being able to call in a more complete set of stakeholders—these kinds of approaches are more likely to lead to success.”


By organizing success factors into a framework involving different components of the scaling up process, four key conclusions can be drawn.

First, a key lesson learned from successful scale-up efforts is that large-scale implementation is more likely if the intervention being scaled up is simple and technically sound and there is widespread consensus about its value. An important avenue of implementation research is therefore to simplify delivery—a good example is the landmark Development of Antiretroviral Therapy (DART) trial, which showed that ART can be safely delivered without complex and costly laboratory monitoring [41].

Second, the chances of success are likely to be increased by strong leadership and governance and the active engagement of a broad range of implementers, including non-state actors. Based on their experiences of successful scale-up, interviewees emphasized that GHIs are likely to fail unless they engage local implementers and the recipient community itself, an assertion supported by a growing body of research evidence.

Third, there is no single or straightforward delivery strategy that offers a formula for success. As Gilson and Schneider say, “there is no simple recipe for managing scaling-up processes” [42]. The framework laid out in this Essay suggests that a wide variety of different strategies could all have an impact. Empirical research will help to define which strategy is best suited to a particular health challenge and setting. Such research will also help implementers to better understand the complex array of contextual factors, such as politics, socio-cultural norms and beliefs, and the fiscal environment, that can influence scale-up success.

Finally, the field of implementation science in LMICs would be advanced if scale-up efforts were always accompanied by research [2]. Any scaling up process, say Hanson and colleagues, should “include both opportunities to learn through action and a way to feed the lessons of experience into strategies to strengthen implementation” [43].

Supporting Information

Text S1.

Search strategy used for literature review.


Table S1.

Basic demographic information on interviewees.



I would like to thank Lorna Guinness for her valuable comments on an early draft of this paper.

Author Contributions

ICMJE criteria for authorship read and met: GY. Agree with the manuscript's results and conclusions: GY. Wrote the first draft of the paper: GY. GY conceived, designed, and conducted the literature review and qualitative study; analyzed the results; and was the sole author of the paper.


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