Citation: Sardi W (2005) Narrow Scope of Vitamin C Review. PLoS Med 2(9): e308. https://doi.org/10.1371/journal.pmed.0020308
Published: September 27, 2005
Copyright: © 2005 William Sardi. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Competing interests: WS is a spokesperson for dietary supplement companies, and author of books on dietary supplements.
Covering 60 years of research without mentioning a paper that highlights flaws in the literature, in a review, should negate any conclusion. In the Cochrane review by Douglas et al. , which is referenced in the Best Practice article by Douglas and Hemilä , there was no mention of the revealing paper published last year by Padayatty et al. , which shows that three-times greater blood concentration can be achieved with an oral dose of vitamin C than previously thought possible. Since viruses increase the demand for ascorbic acid, the oral doses used in the reviewed studies appear trivial, and would not be expected to produce any positive effect. Compare human oral dose studies to what animals synthesize throughout the day. It is obvious that a single dose of a water-soluble vitamin, regardless of the number of milligrams consumed, will not elevate blood plasma levels enough to produce a preventive or therapeutic effect.
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- 2. Douglas RM, Hemilä H (2005) Vitamin C for preventing and treating the common cold. PLoS Med 2: e168.
- 3. Padayatty SJ, Sun H, Wang Y, Riordan HD, Hewitt SM, et al. (2004) Vitamin C pharmacokinetics: Implications for oral and intravenous use. Ann Intern Med 140: 533–537.