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Open Access
Peer-reviewed
Research Article
Associations between Potentially Modifiable Risk Factors and Alzheimer Disease: A Mendelian Randomization Study
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Søren D. Østergaard,
Affiliations Research Department P, Aarhus University Hospital, Risskov, Denmark, Department of Clinical Medicine, Aarhus University, Aarhus, Denmark
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Shubhabrata Mukherjee,
Affiliation Department of Medicine, University of Washington, Seattle, Washington, United States of America
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Stephen J. Sharp,
Affiliation MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, United Kingdom
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Petroula Proitsi,
Affiliation Department of Basic and Clinical Neuroscience, King’s College London, Institute of Psychiatry, Psychology and Neuroscience, London, United Kingdom
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Luca A. Lotta,
Affiliation MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, United Kingdom
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Felix Day,
Affiliation MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, United Kingdom
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John R. B. Perry,
Affiliation MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, United Kingdom
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Kevin L. Boehme,
Affiliation Department of Biology, Brigham Young University, Provo, Utah, United States of America
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Stefan Walter,
Affiliation Department of Epidemiology and Biostatistics, School of Medicine, University of California San Francisco, San Francisco, California, United States of America
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John S. Kauwe,
Affiliation Department of Biology, Brigham Young University, Provo, Utah, United States of America
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Laura E. Gibbons,
Affiliation Department of Medicine, University of Washington, Seattle, Washington, United States of America
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Alzheimer’s Disease Genetics Consortium ,
¶Membership of the Alzheimer’s Disease Genetics Consortium, the Genetic and Environmental Risk in AD (GERAD1) Consortium, and the EPIC-InterAct Consortium is provided in
⨯S1 Text . Data used in the preparation of this article were obtained from GERAD1. As such, the investigators within GERAD1 contributed to the design and implementation of GERAD1 and/or provided data but did not participate in the analysis or writing of this report. -
The GERAD1 Consortium ,
¶Membership of the Alzheimer’s Disease Genetics Consortium, the Genetic and Environmental Risk in AD (GERAD1) Consortium, and the EPIC-InterAct Consortium is provided in
⨯S1 Text . Data used in the preparation of this article were obtained from GERAD1. As such, the investigators within GERAD1 contributed to the design and implementation of GERAD1 and/or provided data but did not participate in the analysis or writing of this report. -
EPIC-InterAct Consortium ,
¶Membership of the Alzheimer’s Disease Genetics Consortium, the Genetic and Environmental Risk in AD (GERAD1) Consortium, and the EPIC-InterAct Consortium is provided in
⨯S1 Text . Data used in the preparation of this article were obtained from GERAD1. As such, the investigators within GERAD1 contributed to the design and implementation of GERAD1 and/or provided data but did not participate in the analysis or writing of this report. -
Eric B. Larson,
Affiliations Department of Medicine, University of Washington, Seattle, Washington, United States of America, Group Health Research Institute, Seattle, Washington, United States of America
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John F. Powell,
Affiliation Department of Basic and Clinical Neuroscience, King’s College London, Institute of Psychiatry, Psychology and Neuroscience, London, United Kingdom
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Claudia Langenberg,
Affiliation MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, United Kingdom
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Paul K. Crane,
Affiliation Department of Medicine, University of Washington, Seattle, Washington, United States of America
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Nicholas J. Wareham,
Affiliation MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, United Kingdom
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Robert A. Scott
* E-mail: Robert.Scott@mrc-epid.cam.ac.uk
Affiliation MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, United Kingdom
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Associations between Potentially Modifiable Risk Factors and Alzheimer Disease: A Mendelian Randomization Study
- Søren D. Østergaard,
- Shubhabrata Mukherjee,
- Stephen J. Sharp,
- Petroula Proitsi,
- Luca A. Lotta,
- Felix Day,
- John R. B. Perry,
- Kevin L. Boehme,
- Stefan Walter,
- John S. Kauwe
- Published: June 16, 2015
- https://doi.org/10.1371/journal.pmed.1001841