Multiple morbidities in pregnancy: Time for research, innovation, and action

In a Guest Editorial, James Beeson and colleagues discuss the contribution of nonobstetric morbidity to mortality during and around pregnancy and what needs to be done to address this global health challenge.


Recognizing multimorbidity as an issue affecting pregnant women
Infectious diseases (such as HIV, malaria, tuberculosis, and sexually transmitted infections [STIs]) together with NCDs that are increasingly common in LMICs as a result of demographic, socioeconomic, and environmental changes (cardiovascular disease, diabetes, anemia, micronutrient deficiencies, hypertension, and mental health challenges) each account for substantial morbidity in pregnancy; however, the burden of their combination is less well recognized, and the impacts are not well understood. Some co-occurring morbidities have been well described, such as coinfection with HIV, malaria, or tuberculosis. Curable STIs (syphilis, gonorrhea, chlamydia, trichomonas, and others) likely infect about 40% of pregnant women in sub-Saharan Africa [6], with negative implications for the health of mother and baby. Infectious plus noninfectious multimorbidity is also important, such as malaria with anemia from nutritional deficiencies and tuberculosis with diabetes [1,5]. In LMIC settings, typically most pregnant women are anemic and have significant nutritional deficiencies [1,5], which may have impact on infections and NCDs [7]. Other multimorbidities are likely to have major impacts but are poorly understood. There is a major knowledge gap for many important cooccurring diseases and risk factors, especially the interaction of macro-and micronutrient deficiencies with infections and other conditions. In addition, poor maternal mental health has short-and long-term adverse effects on mothers and babies and has a likely impact on the whole family [8].

Need for research and innovation
Addressing the burden of multimorbidity requires innovation and investment to drive the development of new tools, interventions, and strategies. We have listed the main priorities for research and innovation across levels of healthcare in Box 1. Greater research and innovation are urgently needed to identify common contributing factors and adversely synergistic interactions. Given the increasing burden of NCDs, there is a strong need to understand the interactions between different NCDs, as well as between infections and NCDs, among pregnant women. Clinical research is needed to test the potential of integrated interventions against common comorbidities (e.g., malaria and STIs, including HIV). Testing of interventions should be accompanied by improved surveillance and reporting of multimorbidities and a better understanding of the causes of maternal mortality, especially indirect deaths. Determining pathogenic interactions underlying multimorbidity will be important to guide new interventions, and it is possible that, at least for some conditions, there may be common or interacting pathways that could be targeted (e.g., malaria in pregnancy together with undernutrition leading to low L-arginine levels can compound fetal growth restriction [9]). The use of systems biology approaches and application of platform technologies such as genomics, proteomics, and metabolomics may reveal pathogenesis mechanisms and better define processes to inform interventions and identify biomarkers for diagnostics or risk stratification. It is likely that there are common root causes and contributors for many conditions, such as low education, poverty, conflict and displacement, and fragile or nonfunctional health systems. Research to build knowledge on long-term consequences of multimorbidities in pregnancy for mothers and children is a priority to maximize potential health gains. New diagnostics and screening technologies for conditions that contribute to multimorbidity need to be brought within reach of LMICs: low cost, easy to use, rapid, and deployable in front-line clinics or community settings. Past examples include rapid diagnostic tests (RDTs) for specific infections, glycometers for diabetes, and urine test sticks, to name a few. Nucleic acid amplification technologies for highly sensitive testing of infections or risk factors are becoming simpler to use, more portable, and cheaper and may offer future solutions [10].
To achieve these advances also requires greater investment by industry and biotech in technologies and products for maternal health (including diagnostics, therapeutics, vaccines, and mHealth). Current levels of investment in research and development (R&D) in this field are very low, with very few new therapeutics, vaccines, or diagnostics for maternal health conditions being licensed in recent decades. Pregnant women are usually excluded from clinical trials of medical products, which has limited their access to the benefits of medical advances. Public-private partnerships and cofunding or incentive schemes could be used to enhance R&D investment, as has proven successful in several diseases. We argue that there should be a wider inclusion of pregnant women in clinical and implementation research; this will provide pregnancy-specific knowledge and help integrate maternal health into broader health solutions. frequently asymptomatic and have major impacts, such as curable STIs, poor nutrition, HIV, malaria, and others. Multimorbidity also demands more integrated service delivery, providing quality care that addresses the full spectrum of health needs of each woman; however, current evidence on how best to integrate pregnancy interventions into primary healthcare or public health programs, such as immunization programs, is insufficient to guide policy [11]. Also critical is integration through to postnatal care, which currently has unacceptably low coverage in LMICs and is typically provided through models that pay little attention to maternal multimorbidity [12]. Postnatal visits and even infant immunization visits represent key opportunities for further screening and follow-up of maternal conditions identified in pregnancy and childbirth.

Challenges for health services
Essential and just as urgent is the development and enabling of a sustainable health workforce that is trained for the challenges posed by multimorbidity. Significant shortages in the global health workforce, especially midwives and obstetricians, including access to continuing professional development, severely constrain the system's capacity to provide quality care. Quality maternal and newborn care needs an emphasis on accessible and respectful care, prevention, and management of complications within a functional health system [13]. Box 1. Priorities in research and innovation to address multimorbidities in pregnancy.

Conclusion
The burden of multimorbidity in pregnancy, combined with global epidemiological changes in disease patterns and resource and health system constraints, poses challenges that can best be addressed by accelerating sustainable improvements in maternal health. Renewed and strengthened focus, research and innovation, and investment and partnerships to address this challenge are urgently needed.