New Clinical Decision Instruments Can and Should Reduce Radiation Exposure

In this Perspective linked to Rodriguez and colleagues, Emmanuel Lagarde discusses the importance of decision instruments that can help physicians avoid subjecting patients to radiation exposure from unnecessary CT scans.


Medical Ionizing Radiations Is Now a Concern
Ionizing radiation has long been known to increase cancer risk, evidenced in particular by the epidemiological follow-up of Hiroshima and Nagasaki bombings survivors, who were typically exposed to high radiation levels over a short period of time. A recent landmark study measured with unprecedented precision the association of long-term exposure to low-dose radiation with increased mortality from leukemia [2]. The authors estimated that each additional 100 mSv exposure raises the excess relative risk of leukemia death by 0.3. The yearly natural background radiation dose is 1-2 mSv, a chest X-ray is 0.01 mSv, and a chest CT radiation dose is about 7 mSv. Between 1998 and 2007 in the United States, the proportion of injury-related visits during which a CT was performed increased from 6% to 15% [3]. In developed countries, medically related radiation now accounts for more than half of the overall annual radiation dose received, the other half coming from radon in the atmosphere, cosmic rays, terrestrial radionuclides, and ingestion [4]. In addition to the necessity of reducing health system costs, we are therefore facing a new crisis with an urgent need to develop and validate alternative screening and diagnosis tools without compromising the patient's prognosis. CT imaging is particularly on the spot, as it accounts for two-thirds of all medical radiation [5].

Success Stories to Reduce Medical Radiation
The DIs described in the article by Rodriguez and colleagues join several previous examples of diagnostic algorithms that can reduce radiation exposure. Because of its very high (>99%) negative predictive value, serological measurement of S100-B protein shows potential to identify 20% to 30% of mild head trauma patients as having no need of imaging [6][7]. Traumatic brain injury, with an annual incidence of about two in 1,000, is the source of a huge proportion of CT-related ionizing doses, the highest (as measured in joule per kilogram of matter) when considering head CTs are focused entirely on one organ [8]. S100-B measurement is, however, not established as a systematic procedure in emergency departments, probably because its low specificity prevents it from fully replacing CT scan. Similarly, ultrasound detection of obstructive pyelolephritis is more and more often considered as an alternative to CT imaging [9]. Thoracic ultrasound in the diagnosis of pleural effusion, consolidation, pulmonary edema, and pneumothorax is also promising in this respect, but adequate validation studies are still missing [10].

The Case of Children
The use of ionizing radiation in pediatric examinations is of particular concern for two reasons: children are probably more vulnerable to radiation (because of a higher rate of mitosis) and have a longer life span to develop long-term effects. Parsimony in the use of CT is therefore particularly important in children. A good example is the 50% substitution over 4 years of ultrasound for CT in appendicitis diagnosis in the US, with no adverse consequences [11]. This rapid change in practice was possible because ultrasound for appendicitis exhibits both relatively high (>90%) negative and positive predictive values (NPVs and PPVs), which has permitted both excluding appendicitis based on ultrasound examination (high NPV) and triage of children directly to surgery without need for CT imaging (high PPV). An inflammation-related biomarker panel has also been proposed to raise NPV close to 100% [12].

Next Steps
One of the hurdles to CT use reduction is sometimes also the clinician's reluctance to do without a powerful investigation tool that reduces the stress of uncertainty. The process of CT examination can, however, be stressful for patients; avoiding such anxiety-when safe to do so -might play a role in the recovery process. In addition to the data presented this week in PLOS Medicine, Rodriguez and colleagues also recently published the results of an original study showing patients' increased willingness to discuss the pros and cons of CT prior to receiving imaging [13]. Facing the double challenge of high costs and evidence of cancer risk associated with accumulated low-dose radiation, research efforts should be promoted to identify new DIs based on biomarkers, clinical observation, and low or zero ionizing dose imaging tools and to evaluate those DIs that have already been proposed.

Author Contributions
Wrote the first draft of the manuscript: EL. Contributed to the writing of the manuscript: EL. Agree with the manuscript's results and conclusions: EL. The author has read, and confirm that he meets, ICMJE criteria for authorship.