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Patient-reported outcomes and survival in multiple sclerosis: A 10-year retrospective cohort study using the Multiple Sclerosis Impact Scale–29

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Longitudinally worsening MSIS-29-PHYS scores are associated with reduced survival time.

Four subgroups are presented in this figure: Subgroup 1—initial MSIS-29-PHYS score 20–84, no worsening after 1 year (solid line); Subgroup 2—initial MSIS-29-PHYS score 20–84, worsening after 1 year (short-dashed line); Subgroup 3—initial MSIS-29-PHYS score 85–100, no worsening after 1 year (dot-dashed line); Subgroup 4—initial MSIS-29-PHYS score 85–100, worsening after 1 year (long-dashed line). (A) Table: Subgroups 1 and 2 had no statistically significant difference in survival time (HR = 1.289, 95% CI 0.843–1.972, p = 0.241). Subgroup 4 had reduced survival time compared with subgroup 3 (HR = 2.266, 95% CI 1.163–4.413, p = 0.016). p < 0.001 for differences between the 4 subgroups. (B) Kaplan–Meier failure curves (n = 872). Note that Kaplan–Meier curves do not account for the effect of age and sex on survival time. HR, hazard ratio; MSIS-29, Multiple Sclerosis Impact Scale–29; MSIS-29-PHYS, MSIS-29 physical.

Fig 3

doi: https://doi.org/10.1371/journal.pmed.1002346.g003