Sequential chemo-immunotherapy followed by standard versus reduced thoracic radiotherapy for older and/or frail stage III non-small-cell lung cancer: A randomized open-label cohort trial

• Wei-Xiang Qi ,

  Contributed equally to this work with: Wei-Xiang Qi, Shuyan Li, Mengdi Wang

  Roles Conceptualization, Formal analysis, Funding acquisition, Methodology, Writing – original draft, Writing – review & editing

  * E-mail: qiweixiang1113@163.com (W-XQ); cjy11756@rjh.com.cn (JC); xy11077@rjh.com.cn (YX); zsg10935@rjh.com.cn (SZ)

  Affiliations Department of Radiation Oncology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China, Shanghai Key Laboratory of Proton-therapy, Shanghai, China

  https://orcid.org/0000-0001-5484-3343

  ⨯
• Shuyan Li ,

  Contributed equally to this work with: Wei-Xiang Qi, Shuyan Li, Mengdi Wang

  Roles Project administration, Supervision, Validation, Visualization

  Affiliations Department of Radiation Oncology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China, Shanghai Key Laboratory of Proton-therapy, Shanghai, China

  ⨯
• Mengdi Wang ,

  Contributed equally to this work with: Wei-Xiang Qi, Shuyan Li, Mengdi Wang

  Roles Investigation, Resources, Software, Supervision

  Affiliations Department of Radiation Oncology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China, Shanghai Key Laboratory of Proton-therapy, Shanghai, China

  https://orcid.org/0009-0009-2743-1402

  ⨯
• Huan Li,

  Roles Investigation, Software

  Affiliations Department of Radiation Oncology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China, Shanghai Key Laboratory of Proton-therapy, Shanghai, China

  ⨯
• Feifei Xu,

  Roles Data curation, Methodology

  Affiliations Department of Radiation Oncology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China, Shanghai Key Laboratory of Proton-therapy, Shanghai, China

  ⨯
• Lei Yao,

  Roles Formal analysis, Methodology, Resources

  Affiliations Department of Radiation Oncology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China, Shanghai Key Laboratory of Proton-therapy, Shanghai, China

  ⨯
• Biao Yu,

  Roles Data curation, Formal analysis, Methodology

  Affiliations Department of Radiation Oncology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China, Shanghai Key Laboratory of Proton-therapy, Shanghai, China

  ⨯
• Linlin Chen,

  Roles Data curation, Formal analysis, Software, Visualization

  Affiliations Department of Radiation Oncology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China, Shanghai Key Laboratory of Proton-therapy, Shanghai, China

  ⨯
• Gang Cai,

  Roles Conceptualization, Data curation, Investigation, Supervision, Validation

  Affiliations Department of Radiation Oncology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China, Shanghai Key Laboratory of Proton-therapy, Shanghai, China

  https://orcid.org/0000-0001-8071-4422

  ⨯
• Cheng Xu,

  Roles Supervision, Validation, Visualization

  Affiliations Department of Radiation Oncology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China, Shanghai Key Laboratory of Proton-therapy, Shanghai, China

  ⨯
• Xianwen Sun,

  Roles Investigation, Methodology, Validation

  Affiliation Department of Respiration and Critical Care Medicine, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China

  ⨯
• Zhiyao Bao,

  Roles Data curation, Resources, Software

  Affiliation Department of Respiration and Critical Care Medicine, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China

  ⨯
• Jiayi Chen ,

  Roles Conceptualization, Supervision, Writing – review & editing

  * E-mail: qiweixiang1113@163.com (W-XQ); cjy11756@rjh.com.cn (JC); xy11077@rjh.com.cn (YX); zsg10935@rjh.com.cn (SZ)

  Affiliations Department of Radiation Oncology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China, Shanghai Key Laboratory of Proton-therapy, Shanghai, China

  https://orcid.org/0000-0001-6417-290X

  ⨯
• Yi Xiang ,

  Roles Conceptualization, Writing – original draft

  * E-mail: qiweixiang1113@163.com (W-XQ); cjy11756@rjh.com.cn (JC); xy11077@rjh.com.cn (YX); zsg10935@rjh.com.cn (SZ)

  Affiliation Department of Respiration and Critical Care Medicine, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China

  https://orcid.org/0000-0002-0724-6359

  ⨯
• Shengguang Zhao

  Roles Conceptualization, Data curation, Software

  * E-mail: qiweixiang1113@163.com (W-XQ); cjy11756@rjh.com.cn (JC); xy11077@rjh.com.cn (YX); zsg10935@rjh.com.cn (SZ)

  Affiliations Department of Radiation Oncology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China, Shanghai Key Laboratory of Proton-therapy, Shanghai, China

  https://orcid.org/0000-0002-4197-8887

  ⨯