Association between early methadone dose titration and treatment discontinuation and opioid toxicity: A retrospective cohort study

• Ria Garg ,

  Roles Conceptualization, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Validation, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: ria.garg@mail.utoronto.ca

  Affiliations ICES, Toronto, Ontario, Canada, Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada

  https://orcid.org/0000-0003-2572-0170

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• Jin Luo,

  Roles Formal analysis, Validation, Writing – review & editing

  Affiliation ICES, Toronto, Ontario, Canada

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• Nikki Bozinoff,

  Roles Conceptualization, Methodology, Supervision, Visualization, Writing – review & editing

  Affiliations Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, Ontario, Canada, Department of Family and Community Medicine, University of Toronto, Toronto, Ontario, Canada

  https://orcid.org/0000-0001-9512-7407

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• Beth Sproule,

  Roles Conceptualization, Methodology, Supervision, Visualization, Writing – review & editing

  Affiliations Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada, Centre for Addiction and Mental Health, Toronto, Ontario, Canada, Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada

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• Tony Antoniou,

  Roles Conceptualization, Methodology, Supervision, Visualization, Writing – review & editing

  Affiliation ICES, Toronto, Ontario, Canada

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• Jennifer Wyman,

  Roles Conceptualization, Visualization, Writing – review & editing

  Affiliations Department of Family and Community Medicine, University of Toronto, Toronto, Ontario, Canada, Division of Addiction Medicine, Women’s College Hospital, Toronto, Ontario, Canada

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• Pamela Leece,

  Roles Conceptualization, Visualization, Writing – review & editing

  Affiliations Department of Family and Community Medicine, University of Toronto, Toronto, Ontario, Canada, Public Health Ontario, Toronto, Ontario, Canada, University of Toronto Dalla Lana School of Public Health, Toronto, Ontario, Canada

  https://orcid.org/0000-0001-8374-6518

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• Charlotte Munro,

  Roles Conceptualization, Validation, Visualization, Writing – review & editing

  Affiliation Ontario Drug Policy Research Network Lived Experience Advisory Group, Toronto, Ontario, Canada

  https://orcid.org/0000-0003-1911-7586

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• Jes Besharh,

  Roles Conceptualization, Validation, Visualization, Writing – review & editing

  Affiliation Ontario Drug Policy Research Network Lived Experience Advisory Group, Toronto, Ontario, Canada

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• Tara Gomes

  Roles Conceptualization, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Validation, Visualization, Writing – review & editing

  Affiliations ICES, Toronto, Ontario, Canada, Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada, Li Ka Shing Knowledge Institute, St. Michael’s Hospital, Toronto, Ontario, Canada, Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, Ontario, Canada

  https://orcid.org/0000-0002-1468-1965

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