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Open Access
Peer-reviewed
Research Article
Frailty in randomized controlled trials of glucose-lowering therapies for type 2 diabetes: An individual participant data meta-analysis of frailty prevalence, treatment efficacy, and adverse events
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Heather Wightman,
Roles Data curation, Writing – original draft
Affiliation School of Health and Wellbeing, University of Glasgow, Glasgow, United Kingdom
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Elaine Butterly,
Roles Data curation, Investigation, Writing – review & editing
Affiliation School of Health and Wellbeing, University of Glasgow, Glasgow, United Kingdom
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Lili Wei,
Roles Data curation, Writing – review & editing
Affiliation School of Health and Wellbeing, University of Glasgow, Glasgow, United Kingdom
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Ryan McChrystal,
Roles Data curation, Investigation, Writing – review & editing
Affiliation School of Health and Wellbeing, University of Glasgow, Glasgow, United Kingdom
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Naveed Sattar,
Roles Writing – review & editing
Affiliation School of Cardiovascular and Metabolic Health, University of Glasgow, Glasgow, United Kingdom
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Amanda Adler,
Roles Writing – review & editing
Affiliation Diabetes Trials Unit, University of Oxford, Oxford, United Kingdom
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David Phillippo,
Roles Methodology, Writing – review & editing
Affiliation Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, United Kingdom
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Sofia Dias,
Roles Methodology, Writing – review & editing
Affiliation Centre for Reviews and Dissemination, University of York, York, United Kingdom
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Nicky Welton,
Roles Methodology, Writing – review & editing
Affiliation Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, United Kingdom
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Andrew Clegg,
Roles Methodology, Writing – review & editing
Affiliation Academic Unit for Ageing and Stroke Research, Bradford Teaching Hospitals NHS Foundation Trust, University of Leeds, Bradford, United Kingdom
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Miles Witham,
Roles Methodology, Writing – review & editing
Affiliations AGE Research Group, Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Leeds, United Kingdom, NIHR Newcastle Biomedical Research Centre, Newcastle upon Tyne NHS Foundation Trust, Cumbria Northumberland Tyne and Wear NHS Foundation Trust and Newcastle University, Newcastle, United Kingdom
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Kenneth Rockwood,
Roles Methodology, Writing – review & editing
Affiliation Division of Geriatric Medicine, Dalhousie University and Nova Scotia Health, Halifax, Nova Scotia, Canada
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David A. McAllister,
Roles Conceptualization, Formal analysis, Investigation, Methodology, Writing – review & editing
Affiliation School of Health and Wellbeing, University of Glasgow, Glasgow, United Kingdom
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Peter Hanlon
Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Supervision, Visualization, Writing – original draft
* E-mail: Peter.hanlon@glasgow.ac.uk
Affiliation School of Health and Wellbeing, University of Glasgow, Glasgow, United Kingdom
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Frailty in randomized controlled trials of glucose-lowering therapies for type 2 diabetes: An individual participant data meta-analysis of frailty prevalence, treatment efficacy, and adverse events
- Heather Wightman,
- Elaine Butterly,
- Lili Wei,
- Ryan McChrystal,
- Naveed Sattar,
- Amanda Adler,
- David Phillippo,
- Sofia Dias,
- Nicky Welton,
- Andrew Clegg
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- Published: April 7, 2025
- https://doi.org/10.1371/journal.pmed.1004553