Octreotide-LAR in later-stage autosomal dominant polycystic kidney disease (ALADIN 2): A randomized, double-blind, placebo-controlled, multicenter trial

• Norberto Perico ,

  Contributed equally to this work with: Norberto Perico, Piero Ruggenenti

  Roles Conceptualization, Investigation, Writing – original draft, Writing – review & editing

  Affiliation Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Bergamo, Italy

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• Piero Ruggenenti ,

  Contributed equally to this work with: Norberto Perico, Piero Ruggenenti

  Roles Conceptualization, Data curation, Formal analysis, Methodology, Writing – original draft, Writing – review & editing

  * E-mail: pruggenenti@asst-pg23.it

  Affiliations Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Bergamo, Italy, Unit of Nephrology and Dialysis, Azienda Socio Sanitaria Territoriale Papa Giovanni XXIII, Bergamo, Italy

  http://orcid.org/0000-0002-8394-0879

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• Annalisa Perna,

  Roles Data curation, Formal analysis, Software, Validation, Writing – review & editing

  Affiliation Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Bergamo, Italy

  http://orcid.org/0000-0002-9257-0283

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• Anna Caroli,

  Roles Data curation, Investigation, Methodology, Software, Writing – review & editing

  Affiliation Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Bergamo, Italy

  http://orcid.org/0000-0002-4130-4663

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• Matias Trillini,

  Roles Data curation, Investigation, Writing – review & editing

  Affiliation Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Bergamo, Italy

  http://orcid.org/0000-0003-1859-1729

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• Sandro Sironi,

  Roles Data curation, Methodology, Writing – review & editing

  Affiliations Department of Diagnostic Radiology, Azienda Socio Sanitaria Territoriale Papa Giovanni XXIII, Bergamo, Italy, Department of Medicine and Surgery, University of Milano–Bicocca, Milan, Italy

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• Antonio Pisani,

  Roles Investigation, Writing – review & editing

  Affiliation Chair of Nephrology, Department of Public Health, University of Naples Federico II, Naples, Italy

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• Eleonora Riccio,

  Roles Investigation, Writing – review & editing

  Affiliation Chair of Nephrology, Department of Public Health, University of Naples Federico II, Naples, Italy

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• Massimo Imbriaco,

  Roles Investigation, Writing – review & editing

  Affiliation Department of Advanced Biomedical Sciences, University of Naples Federico II, Naples, Italy

  http://orcid.org/0000-0003-4414-8464

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• Mauro Dugo,

  Roles Investigation, Writing – review & editing

  Affiliation Nephrology and Dialysis Department, Ca’ Foncello Hospital, Treviso, Italy

  http://orcid.org/0000-0002-5120-7883

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• Giovanni Morana,

  Roles Data curation, Methodology, Writing – review & editing

  Affiliation Department of Radiology, Ca’ Foncello Hospital, Treviso, Italy

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• Antonio Granata,

  Roles Investigation, Writing – review & editing

  Affiliation Unit of Nephrology and Dialysis, San Giovanni di Dio Hospital, Agrigento, Italy

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• Michele Figuera,

  Roles Data curation, Methodology, Writing – review & editing

  Affiliation Radiology Unit, Vittorio Emanuele Policlinico Hospital, Catania, Italy

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• Flavio Gaspari,

  Roles Data curation, Methodology, Writing – review & editing

  Affiliation Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Bergamo, Italy

  http://orcid.org/0000-0001-5941-3481

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• Fabiola Carrara,

  Roles Data curation, Writing – review & editing

  Affiliation Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Bergamo, Italy

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• Nadia Rubis,

  Roles Data curation, Methodology, Validation, Writing – review & editing

  Affiliation Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Bergamo, Italy

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• Alessandro Villa,

  Roles Data curation, Methodology, Validation, Writing – review & editing

  Affiliation Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Bergamo, Italy

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• Sara Gamba,

  Roles Investigation, Writing – review & editing

  Affiliation Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Bergamo, Italy

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• Silvia Prandini,

  Roles Investigation, Writing – review & editing

  Affiliation Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Bergamo, Italy

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• Monica Cortinovis,

  Roles Data curation, Methodology, Writing – review & editing

  Affiliation Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Bergamo, Italy

  http://orcid.org/0000-0001-9834-7069

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• Andrea Remuzzi,

  Roles Conceptualization, Methodology, Software, Writing – review & editing

  Affiliations Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Bergamo, Italy, Department of Management, Information and Production Engineering, University of Bergamo, Bergamo, Italy

  http://orcid.org/0000-0002-4301-8927

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• Giuseppe Remuzzi,

  Roles Conceptualization, Writing – original draft, Writing – review & editing

  Affiliations Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Bergamo, Italy, L. Sacco Department of Biomedical and Clinical Sciences, University of Milan, Milan, Italy

  http://orcid.org/0000-0002-6194-3446

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•  [ ... ],
• for the ALADIN 2 Study Group

  ¶Membership of the ALADIN 2 Study Group is provided in S1 Appendix.

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