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Open Access
Peer-reviewed
Research Article
Genetic Predisposition to Increased Blood Cholesterol and Triglyceride Lipid Levels and Risk of Alzheimer Disease: A Mendelian Randomization Analysis
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Petroula Proitsi ,
* E-mail: petroula.proitsi@kcl.ac.uk
Affiliations King's College London, Institute of Psychiatry, Psychology and Neuroscience, London, United Kingdom, Department of Psychiatry, State Key Laboratory of Brain and Cognitive Sciences, and Centre for Genomic Sciences, Li Ka Shing Faculty of Medicine, the University of Hong Kong, Hong Kong
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Michelle K. Lupton,
Affiliation Neuroimaging Genetics, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia
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Latha Velayudhan,
Affiliation Department of Health Sciences, Psychiatry for the Elderly, University of Leicester, United Kingdom
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Stephen Newhouse,
Affiliation King's College London, Institute of Psychiatry, Psychology and Neuroscience, London, United Kingdom
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Isabella Fogh,
Affiliation King's College London, Institute of Psychiatry, Psychology and Neuroscience, London, United Kingdom
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Magda Tsolaki,
Affiliation Department of Health Sciences, Psychiatry for the Elderly, University of Leicester, United Kingdom
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Makrina Daniilidou,
Affiliation Department of Health Sciences, Psychiatry for the Elderly, University of Leicester, United Kingdom
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Megan Pritchard,
Affiliation King's College London, Institute of Psychiatry, Psychology and Neuroscience, London, United Kingdom
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Iwona Kloszewska,
Affiliation Department of Old Age Psychiatry & Psychotic Disorders, Medical University of Lodz, Lodz, Poland
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Hilkka Soininen,
Affiliation Department of Neurology, Kuopio University Hospital and University of Eastern Finland, Kuopio, Finland
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Patrizia Mecocci,
Affiliation Section of Gerontology and Geriatrics, Department of Medicine, University of Perugia, Perugia, Italy
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Bruno Vellas,
Affiliation Department of Internal and Geriatrics Medicine, INSERM U 1027, Gerontopole, Hôpitaux de Toulouse, Toulouse, France
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for the Alzheimer's Disease Neuroimaging Initiative ,
¶Data used in preparation of this article were obtained from the Alzheimer's Disease Neuroimaging Initiative (ADNI) database (adni.loni.usc.edu). As such, the investigators within the ADNI contributed to the design and implementation of ADNI and/or provided data but did not participate in analysis or writing of this report. Membership of the Alzheimer's Disease Neuroimaging Initiative (ADNI) can be found in the Acknowledgments section.
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Julie Williams,
Affiliation MRC Centre for Neuropsychiatric Genetics and Genomics, Department of Psychological Medicine and Neurology, School of Medicine, Cardiff University, Cardiff, United Kingdom
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for the GERAD1 Consortium ,
¶‡ Data used in the preparation of this article were obtained from the Genetic and Environmental Risk for Alzheimer's disease (GERAD1) Consortium. As such, the investigators within the GERAD1 consortia contributed to the design and implementation of GERAD1 and/or provided data but did not participate in analysis or writing of this report. Membership of the GERAD1 Consortium is provided in the Acknowledgments section.
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Robert Stewart,
Affiliation King's College London, Institute of Psychiatry, Psychology and Neuroscience, London, United Kingdom
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Pak Sham,
Affiliation Department of Psychiatry, State Key Laboratory of Brain and Cognitive Sciences, and Centre for Genomic Sciences, Li Ka Shing Faculty of Medicine, the University of Hong Kong, Hong Kong
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Simon Lovestone,
Affiliation University of Oxford, Department of Psychiatry, Warneford Hospital, Oxford, United Kingdom
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John F. Powell
Affiliation King's College London, Institute of Psychiatry, Psychology and Neuroscience, London, United Kingdom
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Genetic Predisposition to Increased Blood Cholesterol and Triglyceride Lipid Levels and Risk of Alzheimer Disease: A Mendelian Randomization Analysis
- Petroula Proitsi,
- Michelle K. Lupton,
- Latha Velayudhan,
- Stephen Newhouse,
- Isabella Fogh,
- Magda Tsolaki,
- Makrina Daniilidou,
- Megan Pritchard,
- Iwona Kloszewska,
- Hilkka Soininen
- Published: September 16, 2014
- https://doi.org/10.1371/journal.pmed.1001713