Exploring the Developmental Overnutrition Hypothesis Using Parental–Offspring Associations and FTO as an Instrumental Variable

Debbie A Lawlor; Nicholas J Timpson; Roger M Harbord; Sam Leary; Andy Ness; Mark I McCarthy; Timothy M Frayling; Andrew T Hattersley; George Davey Smith

doi:10.1371/journal.pmed.0050033

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Peer-reviewed

Research Article

Exploring the Developmental Overnutrition Hypothesis Using Parental–Offspring Associations and FTO as an Instrumental Variable

Debbie A Lawlor ,

*To whom correspondence should be addressed. E-mail: d.a.lawlor@bristol.ac.uk

Affiliations Medical Research Council Centre for Causal Analyses in Translational Epidemiology, University of Bristol, Bristol, United Kingdom , Department of Social Medicine, University of Bristol, Bristol, United Kingdom
⨯
Nicholas J Timpson,

Affiliations Medical Research Council Centre for Causal Analyses in Translational Epidemiology, University of Bristol, Bristol, United Kingdom , Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom
⨯
Roger M Harbord,

Affiliation Department of Social Medicine, University of Bristol, Bristol, United Kingdom
⨯
Sam Leary,

Affiliation Department of Oral and Dental Science, University of Bristol, Bristol, United Kingdom
⨯
Andy Ness,

Affiliation Department of Oral and Dental Science, University of Bristol, Bristol, United Kingdom
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Mark I McCarthy,

Affiliations Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom , Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, United Kingdom
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Timothy M Frayling,

Affiliations Genetics of Complex Traits, Institute of Biomedical and Clinical Sciences, Peninsula Medical School, Exeter, United Kingdom , Diabetes Genetics, Institute of Biomedical and Clinical Sciences, Peninsula Medical School, Exeter, United Kingdom
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Andrew T Hattersley,

Affiliations Genetics of Complex Traits, Institute of Biomedical and Clinical Sciences, Peninsula Medical School, Exeter, United Kingdom , Diabetes Genetics, Institute of Biomedical and Clinical Sciences, Peninsula Medical School, Exeter, United Kingdom
⨯
George Davey Smith

Affiliations Medical Research Council Centre for Causal Analyses in Translational Epidemiology, University of Bristol, Bristol, United Kingdom , Department of Social Medicine, University of Bristol, Bristol, United Kingdom
⨯

Exploring the Developmental Overnutrition Hypothesis Using Parental–Offspring Associations and FTO as an Instrumental Variable

Debbie A Lawlor,
Nicholas J Timpson,
Roger M Harbord,
Sam Leary,
Andy Ness,
Mark I McCarthy,
Timothy M Frayling,
Andrew T Hattersley,
George Davey Smith

Published: March 11, 2008
https://doi.org/10.1371/journal.pmed.0050033

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31 Mar 2009
00:33 GMT
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AUTHOR’S RESPONSE TO REYNOLDS ET AL: EXPLORING THE DEVELOPMENTAL OVERNUTRITION HYPOTHESIS USING PARENTAL-OFFSPRING ASSOCIATIONS AND FTO AS AN INSTRUMENTAL VARIABLE. Posted by plosmedicine on 31 Mar 2009 at 00:33 GMT
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31 Mar 2009
00:32 GMT
Most Recent

RESPONSE TO LAWLOR ET AL: EXPLORING THE DEVELOPMENTAL OVERNUTRITION HYPOTHESIS USING PARENTAL-OFFSPRING ASSOCIATIONS AND FTO AS AN INSTRUMENTAL VARIABLE. PLOS MEDICINE 2008; 5(3):E33 Posted by plosmedicine on 31 Mar 2009 at 00:32 GMT

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