Combining Information from Common Type 2 Diabetes Risk Polymorphisms Improves Disease Prediction

Michael N Weedon; Mark I McCarthy; Graham Hitman; Mark Walker; Christopher J Groves; Eleftheria Zeggini; N. William Rayner; Beverley Shields; Katharine R Owen; Andrew T Hattersley; Timothy M Frayling

doi:10.1371/journal.pmed.0030374

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Open Access

Peer-reviewed

Research Article

Combining Information from Common Type 2 Diabetes Risk Polymorphisms Improves Disease Prediction

Michael N Weedon,

Affiliation Department of Diabetes Research and Vascular Medicine, Peninsula Medical School, Exeter, United Kingdom
⨯
Mark I McCarthy,

Affiliation Oxford Centre for Diabetes, Endocrinology, and Metabolism, Churchill Hospital, Headington, Oxford, United Kingdom
⨯
Graham Hitman,

Affiliation Centre of Diabetes and Metabolic Medicine, Bart's and the London Queen Mary's School of Medicine and Dentistry, University of London, London, United Kingdom
⨯
Mark Walker,

Affiliation Department of Medicine, School of Medicine, Newcastle-upon-Tyne, United Kingdom
⨯
Christopher J Groves,

Affiliation Oxford Centre for Diabetes, Endocrinology, and Metabolism, Churchill Hospital, Headington, Oxford, United Kingdom
⨯
Eleftheria Zeggini,

Affiliation Oxford Centre for Diabetes, Endocrinology, and Metabolism, Churchill Hospital, Headington, Oxford, United Kingdom
⨯
N. William Rayner,

Affiliation Oxford Centre for Diabetes, Endocrinology, and Metabolism, Churchill Hospital, Headington, Oxford, United Kingdom
⨯
Beverley Shields,

Affiliation Department of Diabetes Research and Vascular Medicine, Peninsula Medical School, Exeter, United Kingdom
⨯
Katharine R Owen,

Affiliation Department of Diabetes Research and Vascular Medicine, Peninsula Medical School, Exeter, United Kingdom
⨯
Andrew T Hattersley,

Affiliation Department of Diabetes Research and Vascular Medicine, Peninsula Medical School, Exeter, United Kingdom
⨯
Timothy M Frayling

*To whom correspondence should be addressed. E-mail: Tim.Frayling@pms.ac.uk

Affiliation Department of Diabetes Research and Vascular Medicine, Peninsula Medical School, Exeter, United Kingdom
⨯

Combining Information from Common Type 2 Diabetes Risk Polymorphisms Improves Disease Prediction

Michael N Weedon,
Mark I McCarthy,
Graham Hitman,
Mark Walker,
Christopher J Groves,
Eleftheria Zeggini,
N. William Rayner,
Beverley Shields,
Katharine R Owen,
Andrew T Hattersley

Published: October 3, 2006
https://doi.org/10.1371/journal.pmed.0030374

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Diabetes mellitus
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