The claim that most published results are false is now over 15 years old. It was based on hypothetical scenarios that made assumptions about the percentage of true hypotheses that scientists test. Today we have empirical studies of the false discovery risk in some research areas. These studies do not support the claim that the false discovery risk is over 50%. In fact, the risk that a significant result with p < .05 is a false positive result is more like 10% to 20% in medicine. it is time to stop citing this outdated article as if it represents a valid fact. See our preprint for a method that can estimate the false discovery risk and the results for medicine.

https://replicationindex....