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These Artificial Sweeteners Increase Cancer Rates by Reducing Testosterone

Posted by jamesmhoward on 06 Apr 2022 at 10:19 GMT

I suggest the underlying cause of the findings of Debras, et al., is low dehydroepiandrosterone (DHEA) and / or testosterone. It is my hypothesis that mammalian evolution occurred because of selection for DHEA and human evolution occurred because of selection of maternal testosterone because testosterone increases intracellular DHEA in the brain by increasing androgen receptors; same thing, accentuated DHEA. I suggest low DHEA and / or excessive testosterone or low testosterone can expose oncogene activity.
In 1994, I first suggested low DHEA is directly involved in initiation of oncogenes: “An Explanation of Cancer and the Increase in Cancer: High Testosterone, Low DHEA and Breast Cancer,” at: which appeared first in publication: Annals of Internal Medicine 2005; 142: 471-472 .
I think testosterone can induce negative effects on DHEA availability when high or low. Low testosterone decreases androgen receptors which decreases DHEA availability and high testosterone can reduce conversion of DHEA sulfate (DHEAS) to the active form, DHEA, by decreasing sulfatase activity. The end result of all of these is reduced DHEA. (Interestingly, I think the “secular trend,” the ongoing increase in birth weight and earlier puberty in children is caused by ongoing selection for high testosterone in girls. The onset of menarche is declining to very early ages and has been doing so for years. This results from increased behavioral selection for testosterone in girls and is the cause, I suggest, for ongoing increases in cancer. Cancer rates are increasing.`)
Aspartame reduces testosterone and a case exists implicating acesulfame-K in low testosterone (
. 1988;44(3):291-300.
doi: 10.1016/0031-9384(88)90028-5).

No competing interests declared.

RE: These Artificial Sweeteners Increase Cancer Rates by Reducing Testosterone

cdebras replied to jamesmhoward on 19 Apr 2022 at 07:35 GMT

Dear Mr. Howard,
Thank you for this interesting hypothesis which is worth exploring.
Best regards,
Charlotte Debras

No competing interests declared.