About the Authors

James Yarmolinsky

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Writing – original draft, Writing – review & editing

james.yarmolinsky@bristol.ac.uk

Affiliations MRC Integrative Epidemiology Unit, University of Bristol, Bristol, United Kingdom, Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, United Kingdom

Virginia Díez-Obrero

Roles Conceptualization, Data curation, Formal analysis, Writing – review & editing

Affiliations Biomarkers and Susceptibility Unit, Oncology Data Analytics Program, Catalan Institute of Oncology (ICO), L’Hospitalet de Llobregat, Barcelona, Spain, Colorectal Cancer Group, ONCOBELL Program, Bellvitge Biomedical Research Institute (IDIBELL), L’Hospitalet de Llobregat, Barcelona, Spain, Consortium for Biomedical Research in Epidemiology and Public Health (CIBERESP), Madrid, Spain

Tom G. Richardson

Roles Writing – review & editing

Affiliations MRC Integrative Epidemiology Unit, University of Bristol, Bristol, United Kingdom, Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, United Kingdom

Marie Pigeyre

Roles Data curation, Writing – review & editing

Affiliations Population Health Research Institute, David Braley Cardiac, Vascular and Stroke Research Institute, Hamilton, Canada, Thrombosis and Atherosclerosis Research Institute, David Braley Cardiac, Vascular and Stroke Research Institute, Hamilton, Canada, Department of Medicine, Michael G. DeGroote School of Medicine, McMaster University, Hamilton, Canada

Jennifer Sjaarda

Roles Writing – review & editing

Affiliations Population Health Research Institute, David Braley Cardiac, Vascular and Stroke Research Institute, Hamilton, Canada, Thrombosis and Atherosclerosis Research Institute, David Braley Cardiac, Vascular and Stroke Research Institute, Hamilton, Canada, Department of Pathology and Molecular Medicine, McMaster University, Michael G. DeGroote School of Medicine, Hamilton, Canada

Guillaume Paré

Roles Writing – review & editing

Affiliations Population Health Research Institute, David Braley Cardiac, Vascular and Stroke Research Institute, Hamilton, Canada, Thrombosis and Atherosclerosis Research Institute, David Braley Cardiac, Vascular and Stroke Research Institute, Hamilton, Canada, Department of Pathology and Molecular Medicine, McMaster University, Michael G. DeGroote School of Medicine, Hamilton, Canada, Department of Clinical Epidemiology and Biostatistics, McMaster University, Ontario, Canada

Venexia M. Walker

Roles Writing – review & editing

Affiliations MRC Integrative Epidemiology Unit, University of Bristol, Bristol, United Kingdom, Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, United Kingdom, Department of Surgery, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, United States of America

Emma E. Vincent

Roles Writing – review & editing

Affiliations MRC Integrative Epidemiology Unit, University of Bristol, Bristol, United Kingdom, Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, United Kingdom, School of Cellular and Molecular Medicine, University of Bristol, Bristol, United Kingdom

Vanessa Y. Tan

Roles Writing – review & editing

Affiliations MRC Integrative Epidemiology Unit, University of Bristol, Bristol, United Kingdom, Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, United Kingdom

Mireia Obón-Santacana

Roles Writing – review & editing

Affiliations Biomarkers and Susceptibility Unit, Oncology Data Analytics Program, Catalan Institute of Oncology (ICO), L’Hospitalet de Llobregat, Barcelona, Spain, Colorectal Cancer Group, ONCOBELL Program, Bellvitge Biomedical Research Institute (IDIBELL), L’Hospitalet de Llobregat, Barcelona, Spain, Consortium for Biomedical Research in Epidemiology and Public Health (CIBERESP), Madrid, Spain

Demetrius Albanes

Roles Data curation, Writing – review & editing

Affiliation Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America

Jochen Hampe

Roles Data curation, Writing – review & editing

Affiliation Department of Medicine I, University Hospital Dresden, Technische Universität Dresden (TU Dresden), Dresden, Germany

Andrea Gsur

Roles Data curation, Writing – review & editing

Affiliation Institute of Cancer Research, Department of Medicine I, Medical University Vienna, Vienna, Austria

Heather Hampel

Roles Data curation, Writing – review & editing

Affiliation Division of Human Genetics, Department of Internal Medicine, The Ohio State University Comprehensive Cancer Center, Columbus, Ohio, United States of America

Rish K. Pai

Roles Data curation, Writing – review & editing

Affiliation Department of Laboratory Medicine and Pathology, Mayo Clinic Arizona, Scottsdale, Arizona, United States of America

Mark Jenkins

Roles Data curation, Writing – review & editing

Affiliation Centre for Epidemiology and Biostatistics, The University of Melbourne, Parkville, Australia

Steven Gallinger

Roles Data curation, Writing – review & editing

Affiliation Division of General Surgery, University Health Network, University of Toronto, Toronto, Canada

Graham Casey

Roles Data curation, Writing – review & editing

Affiliation Center for Public Health Genomics and Department of Public Health Sciences, University of Virginia, Charlottesville, Virginia, United States of America

Wei Zheng

Roles Data curation, Writing – review & editing

Affiliation Division of Epidemiology, Vanderbilt University Medical Center, Vanderbilt University, Nashville, Tennessee, United States of America

Christopher I. Amos

Roles Data curation, Writing – review & editing

Affiliation Department of Medicine, Baylor College of Medicine, Institute for Clinical and Translational Research, Houston, Texas, United States of America

the International Lung Cancer Consortium

Membership of the International Lung Cancer Consortium, Prostate Cancer Association Group to Investigate Cancer Associated Alterations in the Genome (PRACTICAL) consortium, and MEGASTROKE consortium are provided in the Acknowledgments. Information on the PRACTICAL consortium can be found at http://practical.icr.ac.uk/.

the PRACTICAL consortium

Membership of the International Lung Cancer Consortium, Prostate Cancer Association Group to Investigate Cancer Associated Alterations in the Genome (PRACTICAL) consortium, and MEGASTROKE consortium are provided in the Acknowledgments. Information on the PRACTICAL consortium can be found at http://practical.icr.ac.uk/.

the MEGASTROKE consortium

Membership of the International Lung Cancer Consortium, Prostate Cancer Association Group to Investigate Cancer Associated Alterations in the Genome (PRACTICAL) consortium, and MEGASTROKE consortium are provided in the Acknowledgments. Information on the PRACTICAL consortium can be found at http://practical.icr.ac.uk/.

George Davey Smith

Roles Writing – review & editing

Affiliations MRC Integrative Epidemiology Unit, University of Bristol, Bristol, United Kingdom, Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, United Kingdom

Richard M. Martin

Contributed equally to this work with: Richard M. Martin, Victor Moreno

Roles Writing – review & editing

Affiliations MRC Integrative Epidemiology Unit, University of Bristol, Bristol, United Kingdom, Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, United Kingdom, University Hospitals Bristol, NHS Foundation Trust, National Institute for Health Research Bristol Biomedical Research Centre, University of Bristol, Bristol, United Kingdom

Victor Moreno

Contributed equally to this work with: Richard M. Martin, Victor Moreno

Roles Data curation, Methodology, Writing – review & editing

Affiliations Biomarkers and Susceptibility Unit, Oncology Data Analytics Program, Catalan Institute of Oncology (ICO), L’Hospitalet de Llobregat, Barcelona, Spain, Colorectal Cancer Group, ONCOBELL Program, Bellvitge Biomedical Research Institute (IDIBELL), L’Hospitalet de Llobregat, Barcelona, Spain, Consortium for Biomedical Research in Epidemiology and Public Health (CIBERESP), Madrid, Spain, Department of Clinical Sciences, Faculty of Medicine, University of Barcelona, Barcelona, Spain

Competing Interests

I have read the journal’s policy and the authors of this manuscript have the following competing interests: WZ and GDS are on the Editorial Board of PLOS Medicine. GP reported receiving funding from Sanofi (research funding); RKP reported receiving funding from the NIH U01 CA167551-09 (grant paid to institution) and Alimentiv, Inc, Allergan, AbbVie, PathAI, Eli Lilly (consulting fees); CIA reported receiving funding from the National Institutes of Health (U19CA203654) and the Cancer Prevention Research Institute of Texas (RR170048); and VM reported receiving funding from the Agency for Management of University and Research Grants (AGAUR) of the Catalan Government (Grant 2017SGR723), the Instituto de Salud Carlos III, co-funded by FEDER funds (Grant PI17-00092), and the National Institutes of Health (Grant R01CA201407). TGR s employed part-time by Novo Nordisk outside of the work presented in this manuscript. HH is on the Scientific Advisory Board for Invitae, Promega, and Genome Medical and has stock in Genome Medical and stock options in GI OnDemand. All remaining authors declare no potential competing interests.