About the Authors

Joshua A. Bell

Roles Conceptualization, Formal analysis, Investigation, Methodology, Visualization, Writing – original draft, Writing – review & editing

j.bell@bristol.ac.uk

Affiliations MRC Integrative Epidemiology Unit, University of Bristol, Bristol, United Kingdom, Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, United Kingdom

Kaitlin H. Wade

Roles Investigation, Methodology, Writing – review & editing

Affiliations MRC Integrative Epidemiology Unit, University of Bristol, Bristol, United Kingdom, Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, United Kingdom

Linda M. O’Keeffe

Roles Investigation, Methodology, Writing – review & editing

Affiliations MRC Integrative Epidemiology Unit, University of Bristol, Bristol, United Kingdom, Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, United Kingdom, School of Public Health, University College Cork, Cork, Ireland

David Carslake

Roles Investigation, Methodology, Writing – review & editing

Affiliations MRC Integrative Epidemiology Unit, University of Bristol, Bristol, United Kingdom, Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, United Kingdom

Emma E. Vincent

Roles Investigation, Methodology, Writing – review & editing

Affiliations MRC Integrative Epidemiology Unit, University of Bristol, Bristol, United Kingdom, Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, United Kingdom, School of Cellular and Molecular Medicine, University of Bristol, Bristol, United Kingdom

Michael V. Holmes

Roles Investigation, Methodology, Writing – review & editing

Affiliations MRC Integrative Epidemiology Unit, University of Bristol, Bristol, United Kingdom, Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, United Kingdom, Clinical Trial Service Unit & Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom, MRC Population Health Research Unit, University of Oxford, Oxford, United Kingdom, National Institute for Health Research Oxford Biomedical Research Centre, Oxford University Hospital, Oxford, United Kingdom

Nicholas J. Timpson

Roles Investigation, Methodology, Writing – review & editing

Affiliations MRC Integrative Epidemiology Unit, University of Bristol, Bristol, United Kingdom, Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, United Kingdom

George Davey Smith

Roles Investigation, Methodology, Supervision, Writing – review & editing

Affiliations MRC Integrative Epidemiology Unit, University of Bristol, Bristol, United Kingdom, Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, United Kingdom

Competing Interests

MVH has collaborated with Boehringer Ingelheim in research, and in adherence to the University of Oxford’s Clinical Trial Service Unit & Epidemiological Studies Unit (CSTU) staff policy, did not accept personal honoraria or other payments from pharmaceutical companies. GDS is a PLOS Medicine editorial board member. No others to declare.