About the Authors

Rahul S. Desikan

Contributed equally to this work with: Rahul S. Desikan, Chun Chieh Fan

rahul.desikan@ucsf.edu (RSD); o.a.andreassen@medisin.uio.no (OAA); amdale@ucsd.edu (AMD)

Affiliation Neuroradiology Section, Department of Radiology and Biomedical Imaging, University of California, San Francisco, California, United States of America

Chun Chieh Fan

Contributed equally to this work with: Rahul S. Desikan, Chun Chieh Fan

Affiliation Department of Cognitive Science, University of California, San Diego, La Jolla, California, United States of America

Yunpeng Wang

Affiliations Department of Neurosciences, University of California, San Diego, La Jolla, California, United States of America, Norwegian Centre for Mental Disorders Research (NORMENT), Institute of Clinical Medicine, University of Oslo, Oslo, Norway, Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway

Andrew J. Schork

Affiliation Department of Cognitive Science, University of California, San Diego, La Jolla, California, United States of America

Howard J. Cabral

Affiliation Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, United States of America

L. Adrienne Cupples

Affiliation Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, United States of America

Wesley K. Thompson

Affiliation Institute for Biological Psychiatry, Sankt Hans Psychiatric Hospital, Roskilde, Denmark

Lilah Besser

Affiliation National Alzheimer’s Coordinating Center, Department of Epidemiology, University of Washington, Seattle, Washington, United States of America

Walter A. Kukull

Affiliation National Alzheimer’s Coordinating Center, Department of Epidemiology, University of Washington, Seattle, Washington, United States of America

Dominic Holland

Affiliation Department of Neurosciences, University of California, San Diego, La Jolla, California, United States of America

Chi-Hua Chen

Affiliation Department of Radiology, University of California, San Diego, La Jolla, California, United States of America

James B. Brewer

Affiliations Department of Neurosciences, University of California, San Diego, La Jolla, California, United States of America, Department of Radiology, University of California, San Diego, La Jolla, California, United States of America, Shiley-Marcos Alzheimer’s Disease Research Center, University of California, San Diego, La Jolla, California, United States of America

David S. Karow

Affiliation Department of Radiology, University of California, San Diego, La Jolla, California, United States of America

Karolina Kauppi

Affiliation Department of Radiology, University of California, San Diego, La Jolla, California, United States of America

Aree Witoelar

Affiliations Norwegian Centre for Mental Disorders Research (NORMENT), Institute of Clinical Medicine, University of Oslo, Oslo, Norway, Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway

Celeste M. Karch

Affiliation Department of Psychiatry, Washington University, St. Louis, Missouri, United States of America

Luke W. Bonham

Affiliation Department of Neurology, University of California, San Francisco, California, United States of America

Jennifer S. Yokoyama

Affiliation Department of Neurology, University of California, San Francisco, California, United States of America

Howard J. Rosen

Affiliation Department of Neurology, University of California, San Francisco, California, United States of America

Bruce L. Miller

Affiliation Department of Neurology, University of California, San Francisco, California, United States of America

William P. Dillon

Affiliation Neuroradiology Section, Department of Radiology and Biomedical Imaging, University of California, San Francisco, California, United States of America

David M. Wilson

Affiliation Neuroradiology Section, Department of Radiology and Biomedical Imaging, University of California, San Francisco, California, United States of America

Christopher P. Hess

Affiliation Neuroradiology Section, Department of Radiology and Biomedical Imaging, University of California, San Francisco, California, United States of America

Margaret Pericak-Vance

Affiliation John P. Hussman Institute for Human Genomics, University of Miami, Miami, Florida, United States of America

Jonathan L. Haines

Affiliations Department of Epidemiology and Biostatistics, Case Western University, Cleveland, Ohio, United States of America, Institute for Computational Biology, Case Western University, Cleveland, Ohio, United States of America

Lindsay A. Farrer

Affiliations Department of Medicine (Biomedical Genetics), Boston University School of Medicine, Boston, Massachusetts, United States of America, Department of Neurology, Boston University School of Medicine, Boston, Massachusetts, United States of America, Department of Ophthalmology, Boston University School of Medicine, Boston, Massachusetts, United States of America, Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, United States of America, Department of Epidemiology, Boston University School of Public Health, Boston, Massachusetts, United States of America

Richard Mayeux

Affiliations Department of Neurology, Columbia University, New York, New York, United States of America, Taub Institute on Alzheimer’s Disease and the Aging Brain, Columbia University, New York, New York, United States of America, Gertrude H. Sergievsky Center, Columbia University, New York, New York, United States of America

John Hardy

Affiliation Department of Molecular Neuroscience, UCL Institute of Neurology, University College London, London, United Kingdom

Alison M. Goate

Affiliations Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America, Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America

Bradley T. Hyman

Affiliation Department of Neurology, Massachusetts General Hospital, Boston, Massachusetts, United States of America

Gerard D. Schellenberg

Affiliation Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, United States of America

Linda K. McEvoy

Affiliation Department of Radiology, University of California, San Diego, La Jolla, California, United States of America

Ole A. Andreassen

rahul.desikan@ucsf.edu (RSD); o.a.andreassen@medisin.uio.no (OAA); amdale@ucsd.edu (AMD)

Affiliations Norwegian Centre for Mental Disorders Research (NORMENT), Institute of Clinical Medicine, University of Oslo, Oslo, Norway, Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway

Anders M. Dale

rahul.desikan@ucsf.edu (RSD); o.a.andreassen@medisin.uio.no (OAA); amdale@ucsd.edu (AMD)

Affiliations Department of Cognitive Science, University of California, San Diego, La Jolla, California, United States of America, Department of Neurosciences, University of California, San Diego, La Jolla, California, United States of America, Department of Radiology, University of California, San Diego, La Jolla, California, United States of America

Competing Interests

I have read the journal's policy and the authors of this manuscript have the following competing interests: JBB served on advisory boards for Elan, Bristol-Myers Squibb, Avanir, Novartis, Genentech, and Eli Lilly and holds stock options in CorTechs Labs, Inc. and Human Longevity, Inc. AMD is a founder of and holds equity in CorTechs Labs, Inc., and serves on its Scientific Advisory Board. He is also a member of the Scientific Advisory Board of Human Longevity, Inc. (HLI), and receives research funding from General Electric Healthcare (GEHC). The terms of these arrangements have been reviewed and approved by the University of California, San Diego in accordance with its conflict of interest policies. AG served on or have served on in the last 3 years the scientific advisory boards of the following companies: Denali Therapeutics, Cognition Therapeutics and AbbVie. BM served as guest editor on PLOS Medicine’s Special Issue on Dementia.

Author Contributions

Conceptualization: RSD CCF YW AJS HJC LAC WKT LB WAK DH CHC JBB DSK KK AW CMK LWB JSY HJR BLM WPD DMW CPH MPV JLH LAF RM JH AMG BTH GDS LKM OAA AMD. Formal analysis: RSD CCF YW AJS HJC LAC WKT LB WAK DH CHC JBB DSK KK AW CMK LWB JSY HJR BLM WPD DMW CPH MPV JLH LAF RM JH AMG BTH GDS LKM OAA AMD. Funding acquisition: RSD CCF YW AJS HJC LAC WKT LB WAK DH CHC JBB DSK KK AW CMK LWB JSY HJR BLM WPD DMW CPH MPV JLH LAF RM JH AMG BTH GDS LKM OAA AMD. Investigation: RSD CCF AMD. Methodology: RSD CCF YW AJS HJC LAC WKT LB WAK DH CHC JBB DSK KK AW CMK LWB JSY HJR BLM WPD DMW CPH MPV JLH LAF RM JH AMG BTH GDS LKM OAA AMD. Project administration: RSD AMD. Resources: RSD CCF YW AJS HJC LAC WKT LB WAK DH CHC JBB DSK KK AW CMK LWB JSY HJR BLM WPD DMW CPH MPV JLH LAF RM JH AMG BTH GDS LKM OAA AMD. Software: RSD CCF AMD. Supervision: RSD AMD. Validation: RSD CCF YW AJS HJC LAC WKT LB WAK DH CHC JBB DSK KK AW CMK LWB JSY HJR BLM WPD DMW CPH MPV JLH LAF RM JH AMG BTH GDS LKM OAA AMD. Visualization: RSD CCF OAA AMD. Writing – original draft: RSD CCF OAA AMD. Writing – review & editing: RSD CCF YW AJS HJC LAC WKT LB WAK DH CHC JBB DSK KK AW CMK LWB JSY HJR BLM WPD DMW CPH MPV JLH LAF RM JH AMG BTH GDS LKM OAA AMD.