About the Authors

Leo McHugh

leo.m@immunexpress.com

Affiliation Immunexpress, Seattle, Washington, United States of America

Therese A. Seldon

Affiliation Immunexpress, Seattle, Washington, United States of America

Roslyn A. Brandon

Affiliation Immunexpress, Seattle, Washington, United States of America

James T. Kirk

Affiliation Immunexpress, Seattle, Washington, United States of America

Antony Rapisarda

Affiliation Immunexpress, Seattle, Washington, United States of America

Allison J. Sutherland

Affiliation Biosurgical Ingenuity, Paddington, Queensland, Australia

Jeffrey J. Presneill

Affiliation Department of Intensive Care Medicine, Mater Health Services, South Brisbane, Queensland, Australia

Deon J. Venter

Affiliations Department of Pathology, Mater Health Services, South Brisbane, Queensland, Australia, School of Medicine, University of Queensland, St. Lucia, Queensland, Australia, Mater Research Institute, University of Queensland, St. Lucia, Queensland, Australia

Jeffrey Lipman

Affiliations Burns Trauma and Critical Care Research Centre, University of Queensland, St. Lucia, Queensland, Australia, Department of Intensive Care Medicine, Royal Brisbane & Women’s Hospital, Herston, Queensland, Australia

Mervyn R. Thomas

Affiliation Emphron Informatics, Toowong, Queensland, Australia

Peter M. C. Klein Klouwenberg

Affiliations Department of Intensive Care, University Medical Center Utrecht, Utrecht, the Netherlands, Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, the Netherlands

Lonneke van Vught

Affiliations Center of Experimental and Molecular Medicine, Academic Medical Center, Amsterdam, the Netherlands, Division of Infectious Diseases, Academic Medical Center, Amsterdam, the Netherlands

Brendon Scicluna

Affiliations Center of Experimental and Molecular Medicine, Academic Medical Center, Amsterdam, the Netherlands, Division of Infectious Diseases, Academic Medical Center, Amsterdam, the Netherlands

Marc Bonten

Affiliation Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, the Netherlands

Olaf L. Cremer

Affiliation Department of Intensive Care, University Medical Center Utrecht, Utrecht, the Netherlands

Marcus J. Schultz

Affiliations Department of Intensive Care Medicine, Academic Medical Center, Amsterdam, the Netherlands, Laboratory of Experimental Intensive Care and Anesthesiology, Academic Medical Center, Amsterdam, the Netherlands

Tom van der Poll

Affiliations Center of Experimental and Molecular Medicine, Academic Medical Center, Amsterdam, the Netherlands, Division of Infectious Diseases, Academic Medical Center, Amsterdam, the Netherlands

Thomas D. Yager

Affiliation Immunexpress, Seattle, Washington, United States of America

Richard B. Brandon

Affiliation Immunexpress, Seattle, Washington, United States of America

Competing Interests

The authors have read the journal’s policy, and declare the following: AJS JL PKK LVV BS MB OC MJS TVDP have no competing interests; TAS LM AR JTK TDY RAB RBB DJV MRT are employees and/or shareholders of Immunexpress, which holds the intellectual property in SeptiCyte Lab; JJP has no competing interests except for this: "In 2010 Immunexpress Inc. paid to the Adult Intensive Care Unit, Mater Health Services, Brisbane, Australia a sum of AUS $38,509 (thirty-eight thousand, five hundred and nine Australian dollars) as half-time temporary salary support for an ICU research coordinator to facilitate patient identification, recruitment and sample collection for 6 months from 20 May 2010.”

Author Contributions

Conceived and designed the experiments: RBB TAS LM RAB AJS DJV MRT JJP JL. Performed the experiments: LM. Analyzed the data: LM TDY AR JTK. Contributed reagents/materials/analysis tools: MRT LM BS PKK LVV AJS. Wrote the first draft of the manuscript: TDY. Contributed to the writing of the manuscript: TDY RBB TAS. Enrolled patients: DJV JL PKK LVV MB OC MJS TVDP AJS JJP. Agree with the manuscript’s results and conclusions: TAS LM RAB JTK AR AJS JJP DJV JL MRT PKK LVV BS MB OC MJS TVDP TDY RBB. All authors have read, and confirm that they meet, ICMJE criteria for authorship.