About the Authors

Lauren E. Mokry

Affiliation Centre for Clinical Epidemiology, Department of Epidemiology, Lady Davis Institute for Medical Research, Jewish General Hospital, McGill University, Montreal, Quebec, Canada

Stephanie Ross

Affiliation Centre for Clinical Epidemiology, Department of Epidemiology, Lady Davis Institute for Medical Research, Jewish General Hospital, McGill University, Montreal, Quebec, Canada

Omar S. Ahmad

Affiliations Centre for Clinical Epidemiology, Department of Epidemiology, Lady Davis Institute for Medical Research, Jewish General Hospital, McGill University, Montreal, Quebec, Canada, Department of Medicine, McGill University, Montreal, Quebec, Canada

Vincenzo Forgetta

Affiliations Centre for Clinical Epidemiology, Department of Epidemiology, Lady Davis Institute for Medical Research, Jewish General Hospital, McGill University, Montreal, Quebec, Canada, Department of Medicine, McGill University, Montreal, Quebec, Canada

George Davey Smith

Affiliation MRC Integrative Epidemiology Unit, School of Social and Community Medicine, University of Bristol, Bristol, United Kingdom

Aaron Leong

Affiliations Division of General Internal Medicine, Massachusetts General Hospital, Boston, Massachusetts, United States of America, Department of Medicine, Harvard Medical School, Boston, Massachusetts, United States of America

Celia M. T. Greenwood

Affiliations Department of Oncology, McGill University, Montreal, Quebec, Canada, Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Montreal, Quebec, Canada, Department of Human Genetics, McGill University, Montreal, Quebec, Canada, Lady Davis Institute, Jewish General Hospital, Montreal, Quebec, Canada

George Thanassoulis

Affiliations Department of Medicine, McGill University, Montreal, Quebec, Canada, Preventive and Genomic Cardiology, McGill University Health Center, Montreal, QC

J. Brent Richards

brent.richards@mcgill.ca

Affiliations Centre for Clinical Epidemiology, Department of Epidemiology, Lady Davis Institute for Medical Research, Jewish General Hospital, McGill University, Montreal, Quebec, Canada, Department of Medicine, McGill University, Montreal, Quebec, Canada, Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Montreal, Quebec, Canada, Department of Human Genetics, McGill University, Montreal, Quebec, Canada, Department of Twin Research and Genetic Epidemiology, King’s College London, United Kingdom

Competing Interests

GT has accepted speaker's fees and consultancy fees from Servier Canada relating to the treatment of hypertension and has participated on an Advisory Board for ISIS Pharmaceuticals for the treatment of dyslipidemia. GT also receives research grants from the Canadian Institute of Health Research and the Heart and Stroke Foundation of Canada. GDS is a member of the Editorial Board of PLOS Medicine. None of these relationships relate to the content/topic of the manuscript under review at PLOS Medicine.

Author Contributions

Conceived and designed the experiments: JBR. Performed the experiments: JBR LEM. Analyzed the data: JBR LEM SR. Contributed reagents/materials/analysis tools: JBR. Wrote the first draft of the manuscript: JBR LEM. Contributed to the writing of the manuscript: LEM JBR SR OSA VF AL CMTG GT GDS. Agree with the manuscript’s results and conclusions: LEM JBR SR OSA VF AL CMTG GT GDS. Created all figures: SR. All authors have read, and confirm that they meet, ICMJE criteria for authorship.