About the Authors

The RTS,S Clinical Trials Partnership (2014)

mhamel@cdc.gov (corresponding author: Mary J. Hamel)

Membership of the RTS,S Clinical Trials Partnership is provided in the Acknowledgments.

Competing Interests

The trial was sponsored by GlaxoSmithKline Biologicals SA (GSK), the vaccine developer and manufacturer, and funded by both GSK Biologicals SA and the PATH Malaria Vaccine Initiative (MVI). All centers declare receiving a grant from MVI for running the trial. Author travel and accommodation related to this trial were financed by MVI. GlaxoSmithKline Biologicals SA received a grant from MVI to run the trial. MVI received a grant from the Bill & Melinda Gates Foundation to run this trial and to compensate MVI authors for trial-related travel. Additional conflicts of interest are as follows: JJA and PAl declare that their institutions received grant from the Catalan government and from the International Agency for Development and Cooperation. NA, CO, and KO declare that their institutions received a grant from the Malaria Clinical Trial Alliance. PB, SD, BG, CK, PL, CMai, GMwam, BO, and LO declare that their institution has received grants from MVI for other malaria studies. KM declares that his institution received a grant from the Wellcome Trust and that he received support from USAID and the Bill & Melinda Gates Foundation to participate in a scientific advisory group on malaria. MML declares that she received non-financial support from the WHO and the Biomérieux Foundation. PN declares that she received financial support from GSK to present the results of the study at ASTMH congress in 2012. LO declares that he received support from GSK to carry out clinical and epidemiological studies. JSa has received (for the Center) some GlaxoSmithKline group of companies' consultancy fees for other studies. MTa is a board member of the Optimus Foundation, and his institution is reimbursed for his activities on the scientific advisory board of the Novartis Institute for Tropical Diseases. He also has received for his institution other grants from MVI and from the Bill & Melinda Gates Foundation, and travel reimbursements from MVI and Sanaria corp. All GSK Vaccines authors are, or were at the time of the study, employed by the GlaxoSmithKline group of companies. JC now works as an independent consultant for GSK Vaccines. WRB, JC, EJ, DLa, OOA, JV, AL, and MLi have shares/stock options in the GlaxoSmithKline group of companies. JC and WRB declare that they are named inventors on patents for which the rights have been assigned to GlaxoSmithKline group of companies. DK, DLe, and BS are employees at PATH-MVI. DSc is employed by the London School of Hygiene & Tropical Medicine, and his consultancy activities for MVI are funded as a grant to the LSHTM by MVI. DK holds stock or stock options from Merck, Sharpe & Dome.

Author Contributions

Conceived and designed the experiments: SAb TA STA DA JJA KPA WRB PB UDA SGe BG MJH IH SK PGK DLa AL BL MLe MLi JL EM KM FM PN OOA AOli LO WO SOA JSa BS LS MTa HT JV. Performed the experiments: OA SAb BPA AAA EA GA SAd TA STA AA PAi PAk PAl DA KPA NA AB JB PB OB HB DC CC RC ED SD DD CD JFF SGe JG SGo MJH SI EJ OAJ ALK PK SK KK CK JK PGK MLa KFL BL MLe EL PL JL OL EM LM CMah CMai AM SM KM FM MML CMav JM BM ATM PM VMK TM GMwam GMwan AN PN RN JOc CO BO AOlo JOm MO IO AOt KO LO WO NO JBO SOA HOB JOy TR JSa NS DSa AS SS HS JSy GT TT TGT HT OT MTs IV AKY. Analyzed the data: SAb SAd STA PAi JJA KPA JB JC SGe BG YG MJH IH EJ SK DK PGK DLa AL DLe MLi JL FM PN BO AOli AOlo MO LO WO SOA JSa BS DSc HS MTa HT JV. Wrote the first draft of the manuscript: SAb JJA BG MJH AL DLe MLi JL PN AOli LO DSc MTa JV. Contributed to the writing of the manuscript: SAb JJA BG MJH AL DLe MLi JL PN AOli LO DSc MTa JV. ICMJE criteria for authorship read and met: OA SAb BPA AAA EA GA SAd TA STA AA PAi PAk PAl DA JJA KPA NA WRB AB JB PB OB HB DC CC RC JC UDA ED SD DD CD JFF SGe JG SGo BG YG MJH IH SI EJ OAJ ALK PK SK DK KK CK JK PGK MLa DLa KFL AL DLe BL MLe MLi EL PL JL OL EM LM CMah CMai AM SM KM FM MML CMav JM BM ATM PM VMK TM GMwam GMwan AN PN RN JOc CO OOA BO AOli AOlo JOm MO IO AOt KO LO WO NO JBO SOA HOB JOy TR JSa NS DSa AS BS DSc SS LS HS JSy MTa GT TT TGT HT OT MTs IV JV AKY. Agree with manuscript results and conclusions: OA SAb BPA AAA EA GA SAd TA STA AA PAi PAk PAl DA JJA KPA NA WRB AB JB PB OB HB DC CC RC JC UDA ED SD DD CD JFF SGe JG SGo BG YG MJH IH SI EJ OAJ ALK PK SK DK KK CK JK PGK MLa DLa KFL AL DLe BL MLe MLi EL PL JL OL EM LM CMah CMai AM SM KM FM MML CMav JM BM ATM PM VMK TM GMwam GMwan AN PN RN JOc CO OOA BO AOli AOlo JOm MO IO AOt KO LO WO NO JBO SOA HOB JOy TR JSa NS DSa AS BS DSc SS LS HS JSy MTa GT TT TGT HT OT MTs IV JV AKY. Enrolled patients: OA SAb BPA AAA EA GA SAd TA STA AA PAi PAk PAl DA KPA NA AB JB PB OB HB DC CC RC ED SD DD CD JFF SGe JG SGo MJH SI EJ OAJ ALK PK SK KK CK JK PGK MLa KFL BL MLe EL PL JL OL EM LM CMah CMai AM SM KM FM MML CMav JM BM ATM PM VMK TM GMwam GMwan AN PN RN JOc CO BO AOlo JOm MO IO AOt KO LO WO NO JBO SOA HOB JOy TR JSa NS DSa AS SS HS JSy GT TT TGT HT OT MTs IV AKY. Developed the analysis plan for the data: JJA MLi. Vouch for the data and analysis: JJA MLi.