About the Authors
- Robert Clarke
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Contributed equally to this work with: Robert Clarke, Derrick A. Bennett, Sarah Parish, Rory Collins, Richard Peto
* E-mail: Robert.Clarke@ctsu.ox.ac.uk
Affiliation Clinical Trial Service Unit and Epidemiological Studies Unit (CTSU), University of Oxford, Oxford, United Kingdom
- Derrick A. Bennett
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Contributed equally to this work with: Robert Clarke, Derrick A. Bennett, Sarah Parish, Rory Collins, Richard Peto
Affiliation Clinical Trial Service Unit and Epidemiological Studies Unit (CTSU), University of Oxford, Oxford, United Kingdom
- Sarah Parish
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Contributed equally to this work with: Robert Clarke, Derrick A. Bennett, Sarah Parish, Rory Collins, Richard Peto
Affiliation Clinical Trial Service Unit and Epidemiological Studies Unit (CTSU), University of Oxford, Oxford, United Kingdom
- Petra Verhoef
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Affiliation Unilever Research and Development, Vlaardingen, The Netherlands
- Mariska Dötsch-Klerk
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Affiliation Unilever Research and Development, Vlaardingen, The Netherlands
- Mark Lathrop
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Affiliation Centre National de Genotypage, Evry, France
- Peng Xu
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Affiliation Centre National de Genotypage, Evry, France
- Børge G. Nordestgaard
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Affiliation Herlev Hospital Department of Clinical Biochemistry, University of Copenhagen, Copenhagen, Denmark
- Hilma Holm
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Affiliation deCODE Inc, Rejkavik, Iceland
- Jemma C. Hopewell
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Affiliation Clinical Trial Service Unit and Epidemiological Studies Unit (CTSU), University of Oxford, Oxford, United Kingdom
- Danish Saleheen
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Affiliations Department of Public Health and Primary Care, University of Cambridge, United Kingdom, Center for Non-Communicable Diseases, Karachi, Pakistan
- Toshihiro Tanaka
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Affiliation RIKEN Centre for Genomic Medicine, Yokohama, Japan
- Sonia S. Anand
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Affiliation Population Health Research Institute, Hamilton, Canada
- John C. Chambers
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Affiliation Imperial College Faculty of Medicine, University of London, London, United Kingdom
- Marcus E. Kleber
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Affiliation Luric Study Non-Profit LCC, University of Freiburg, Freiburg, Germany
- Willem H. Ouwehand
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Affiliation Department of Haematology, University of Cambridge, United Kingdom
- Yoshiji Yamada
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Affiliation Mie University Life Science Research Center, Tsu, Japan
- Clara Elbers
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Affiliation Department of Medical Genetics, University of Utrecht, Utrecht, The Netherlands
- Bas Peters
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Affiliation Utrecht Institute for Pharmaceutical Sciences, University of Utrecht, Utrecht, The Netherlands
- Alexandre F. R. Stewart
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Affiliation Heart Institute, University of Ottawa, Ottawa, Canada
- Muredach M. Reilly
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Affiliation Cardiovascular Institute, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
- Barbara Thorand
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Affiliation Helmholtz Zentrum, Institute of Epidemiology II, German Research Center for Environmental Health, Munich, Germany
- Salim Yusuf
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Affiliation Population Health Research Institute, Hamilton, Canada
- James C. Engert
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Affiliation McGill University Health Centre, Montreal, Canada
- Themistocles L. Assimes
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Affiliation Department of Medicine, Stanford University School of Medicine, Stanford, California, United States of America
- Jaspal Kooner
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Affiliation Imperial College Faculty of Medicine, University of London, London, United Kingdom
- John Danesh
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Affiliation Department of Public Health and Primary Care, University of Cambridge, United Kingdom
- Hugh Watkins
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Affiliation Department of Cardiovascular Medicine, University of Oxford, United Kingdom
- Nilesh J. Samani
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Affiliation Department of Cardiovascular Sciences, University of Leicester, United Kingdom
- Rory Collins
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Contributed equally to this work with: Robert Clarke, Derrick A. Bennett, Sarah Parish, Rory Collins, Richard Peto
Affiliation Clinical Trial Service Unit and Epidemiological Studies Unit (CTSU), University of Oxford, Oxford, United Kingdom
- Richard Peto
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Contributed equally to this work with: Robert Clarke, Derrick A. Bennett, Sarah Parish, Rory Collins, Richard Peto
Affiliation Clinical Trial Service Unit and Epidemiological Studies Unit (CTSU), University of Oxford, Oxford, United Kingdom
- for the MTHFR Studies Collaborative Group
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¶Membership of the
MTHFR Studies Collaborative Group is provided in the Acknowledgments.
Competing Interests
The Clinical Trial Service Unit has a policy of not accepting honoraria or other payments from the pharmaceutical industry, except for reimbursement of costs to participate in scientific meetings (RCl, DAB, SP, JCH, RCo, RP). PV and MDK are employees of Unilever R&D Vlaardingen, The Netherlands. Unilever makes no claims regarding B-vitamins, homocysteine, and CVD on their food products, and PV and MDK have worked on the paper due to their expertise and data from previous academic life. PV and MDK therefore do not consider this to be a competing interest but declare it for reasons of transparency. HH is an employee of deCode, a biotechnology company that produces genetic testing services. JD and RCo are on the Editorial Board of PLoS Medicine. All other authors have declared that no competing interests exist.
Author Contributions
Conceived and designed the experiments: RCl SP RP. Performed the experiments: RCl DAB SP RP. Analyzed the data: RCl DAB SP RP. Contributed reagents/materials/analysis tools: RCl DAB SP PV MDK ML PX BGN HH JCH DS TT SSA JCC MEK WHO YY CE BP AFRS MMR BT SY JCE TLA JK JD HW NJS RCo RP. Wrote the first draft of the manuscript: RCl SP DAB RP. Contributed to the writing of the manuscript: RCl DAB SP RP. ICMJE criteria for authorship read and met: RCl DAB SP PV MDK ML PX BGN HH JCH DS TT SSA JCC MEK WHO YY CE BP AFRS MMR BT SY JCE TLA JK JD HW NJS RCo RP. Agree with manuscript results and conclusions: RCl DAB SP PV MDK ML PX BGN HH JCH DS TT SSA JCC MEK WHO YY CE BP AFRS MMR BT SY JCE TLA JK JD HW NJS RCo RP.