About the Authors

Thomas G Smith

Affiliation Department of Physiology, Anatomy, and Genetics, University of Oxford, Oxford, United Kingdom

Jerome T Brooks

Affiliation Department of Physiology, Anatomy, and Genetics, University of Oxford, Oxford, United Kingdom

George M Balanos

Affiliation School of Sport and Exercise Sciences, University of Birmingham, Birmingham, United Kingdom

Terence R Lappin

Affiliation Centre for Cancer Research and Cell Biology, Queen's University, Belfast, United Kingdom

D. Mark Layton

Affiliation Department of Haematology, Imperial College of Science, Technology, and Medicine, London, United Kingdom

Dawn L Leedham

Affiliation Diagnostics, Therapies, and Cancer Division, Chase Farm Hospital, Middlesex, United Kingdom

Chun Liu

Affiliation Department of Physiology, Anatomy, and Genetics, University of Oxford, Oxford, United Kingdom

Patrick H Maxwell

Affiliation Renal Section, Imperial College of Science, Technology, and Medicine, London, United Kingdom

Mary F McMullin

Affiliation Department of Haematology, Queen's University, Belfast City Hospital, Belfast, United Kingdom

Christopher J McNamara

Affiliation Department of Haematology, Royal Free Hospital, Hampstead, United Kingdom

Melanie J Percy

Affiliation Department of Haematology, Queen's University, Belfast City Hospital, Belfast, United Kingdom

Christopher W Pugh

Affiliation Nuffield Department of Clinical Medicine, University of Oxford, Oxford, United Kingdom

Peter J Ratcliffe

Affiliation Nuffield Department of Clinical Medicine, University of Oxford, Oxford, United Kingdom

Nick P Talbot

Affiliation Department of Physiology, Anatomy, and Genetics, University of Oxford, Oxford, United Kingdom

Marilyn Treacy

Affiliation Diagnostics, Therapies, and Cancer Division, Chase Farm Hospital, Middlesex, United Kingdom

Peter A Robbins

To whom correspondence should be addressed. E-mail: peter.robbins@physiol.ox.ac.uk

Affiliation Department of Physiology, Anatomy, and Genetics, University of Oxford, Oxford, United Kingdom

Competing Interests

PHM, CWP, and PJR are scientific co-founders of ReOx ( http://www.reox.co.uk).

Author Contributions

TGS, JTB, and PAR designed the study. PHM, CWP, and PJR contributed to study design. TGS, TRL, DML, DLL, PHM, MFM, CJM, MJP, CWP, and MT identified and recruited patients to the study. TGS, GMB, CL, and NPT conducted the physiology experiments. JTB conducted the gene expression experiments. TGS, JTB, GMB, TRL, DML, DLL, PHM, MFM, CJM, CWP, PJR, NPT, MT, and PAR analysed the data and contributed to preparation of the paper. TGS, PJR, and PAR wrote the paper.