X-Linked G6PD Deficiency Protects Hemizygous Males but Not Heterozygous Females against Severe Malaria

Aldiouma Guindo; Rick M Fairhurst; Ogobara K Doumbo; Thomas E Wellems; Dapa A Diallo

doi:10.1371/journal.pmed.0040066

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Open Access

Peer-reviewed

Research Article

X-Linked G6PD Deficiency Protects Hemizygous Males but Not Heterozygous Females against Severe Malaria

Aldiouma Guindo ,

Contributed equally to this work with: Aldiouma Guindo, Rick M Fairhurst

Affiliations Malaria Research and Training Center, Faculty of Medicine, Pharmacy, and Odontostomatology, University of Bamako, Mali , Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
⨯
Rick M Fairhurst ,

Contributed equally to this work with: Aldiouma Guindo, Rick M Fairhurst

Affiliation Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
⨯
Ogobara K Doumbo,

Affiliation Malaria Research and Training Center, Faculty of Medicine, Pharmacy, and Odontostomatology, University of Bamako, Mali
⨯
Thomas E Wellems ,

*To whom correspondence should be addressed. E-mail: twellems@niaid.nih.gov

Affiliation Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
⨯
Dapa A Diallo

Affiliation Malaria Research and Training Center, Faculty of Medicine, Pharmacy, and Odontostomatology, University of Bamako, Mali
⨯

X-Linked G6PD Deficiency Protects Hemizygous Males but Not Heterozygous Females against Severe Malaria

Aldiouma Guindo,
Rick M Fairhurst,
Ogobara K Doumbo,
Thomas E Wellems,
Dapa A Diallo

Published: March 13, 2007
https://doi.org/10.1371/journal.pmed.0040066

About the Authors

Aldiouma Guindo

Contributed equally to this work with: Aldiouma Guindo, Rick M Fairhurst

Affiliations Malaria Research and Training Center, Faculty of Medicine, Pharmacy, and Odontostomatology, University of Bamako, Mali , Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America

Rick M Fairhurst

Contributed equally to this work with: Aldiouma Guindo, Rick M Fairhurst

Affiliation Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America

Ogobara K Doumbo

Affiliation Malaria Research and Training Center, Faculty of Medicine, Pharmacy, and Odontostomatology, University of Bamako, Mali

Thomas E Wellems

*To whom correspondence should be addressed. E-mail: twellems@niaid.nih.gov

Affiliation Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America

Dapa A Diallo

Affiliation Malaria Research and Training Center, Faculty of Medicine, Pharmacy, and Odontostomatology, University of Bamako, Mali

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

AG, RMF, OKD, TEW, and DAD contributed in conducting the field research, the analysis and interpretation of the data, and the writing of the manuscript.

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Malaria
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Glucose-6-phosphate dehydrogenase deficiency
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Malarial parasites
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Heterozygosity
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Red blood cells
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Cerebral malaria
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Homozygosity
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Children
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