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Correction: A homozygous KAT2B variant modulates the clinical phenotype of ADD3 deficiency in humans and flies

  • Sara Gonçalves,
  • Julie Patat,
  • Maria Clara Guida,
  • Noelle Lachaussée,
  • Christelle Arrondel,
  • Martin Helmstädter,
  • Olivia Boyer,
  • Olivier Gribouval,
  • Marie-Claire Gubler,
  • Geraldine Mollet,
  • Marlène Rio,
  • Marina Charbit,
  • Christine Bole-Feysot,
  • Patrick Nitschke,
  • Tobias B. Huber,
  • Patricia G. Wheeler,
  • Devon Haynes,
  • Jane Juusola,
  • Thierry Billette de Villemeur,
  • Caroline Nava,
  • Alexandra Afenjar,
  • Boris Keren,
  • Rolf Bodmer,
  • Corinne Antignac,
  •  [ ... ],
  • Matias Simons
  • [ view all ]
  • [ view less ]

Correction: A homozygous KAT2B variant modulates the clinical phenotype of ADD3 deficiency in humans and flies

  • Sara Gonçalves, 
  • Julie Patat, 
  • Maria Clara Guida, 
  • Noelle Lachaussée, 
  • Christelle Arrondel, 
  • Martin Helmstädter, 
  • Olivia Boyer, 
  • Olivier Gribouval, 
  • Marie-Claire Gubler, 
  • Geraldine Mollet
PLOS
x

The legends for Figs 4 and 5 do not match. The legend that is shown for Fig 4 should be for Fig 5, and the legend that is shown for Fig 5 should be for Fig 4.

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Fig 4. Effect of adducin-αγ E559Q on Drosophila heart function.

(A-C) M-mode of beating 2-week-old control (yw/Df(2R); A), adducin-αγ WT (B) and adducin-αγ E559Q (C) rescue hearts. Scale bar: 1 second. (D-H) High-speed movies of beating adducin-αγ WT, adducin-αγ E559Q rescue and control hearts were analysed using semi-automated Optical Heartbeat Analysis [46]. For quantification, 8–19 flies were analyzed. Statistical analysis was performed using one-way ANOVA and Tukey’s multiple comparison, except for Arrhythmia index (H; n = 8–19, Mann-Whitney-Wilcoxon). For all panels: ns, non significant, ***p<0.001 (See S1 Table for details on transgenic flies).

https://doi.org/10.1371/journal.pgen.1007748.g001

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Fig 5. Effect of Gcn5 F304S mutation on Drosophila heart function.

(A-C) M-mode kymographs of 1 day old beating hearts of control flies (yw/Df(3L); A) and Gcn5null flies rescued with Gcn5 WT (B) or Gcn5 F304S (C). Scale bar: 1 second. (D-H) High-speed movies of beating hearts were analysed using semi-automated Optical Heartbeat Analysis [46]. For quantification, 8–19 flies were analyzed. Statistical analysis was performed using one-way ANOVA and Tukey’s multiple comparison for all parameters except arrhythmia index (H), which was analysed using Mann-Whitney-Wilcoxon. For all panels: ns, non significant, *p<0.05 **p<0.01, ***p<0.001, ****p<0.0001 (see S1 Table for details on transgenic flies).

https://doi.org/10.1371/journal.pgen.1007748.g002

Consequently, the seventh sentence under the subheading “KAT2B F307S but not ADD3 E659Q causes cardiac defects in Drosophila” is incorrect. The correct sentence is: Both Gcn5 WT and F304S rescue flies showed a reduction in the normal diastolic diameter compared to control flies (Fig 5F), but only for Gcn5 F304S there was a reduction in contractility, measured as fractional shortening (Fig 5G).

In addition, there are formatting inaccuracies in Table 1. Please see the correct Table 1 here.

Reference

  1. 1. Gonçalves S, Patat J, Guida MC, Lachaussée N, Arrondel C, Helmstädter M, et al. (2018) A homozygous KAT2B variant modulates the clinical phenotype of ADD3 deficiency in humans and flies. PLoS Genet 14(5): e1007386. https://doi.org/10.1371/journal.pgen.100738 pmid:29768408