Concerns have been raised regarding some of the data in the PLOS Genetics article “RNAi-Dependent and Independent Control of LINE1 Accumulation and Mobility in Mouse Embryonic Stem Cells”, notably in panel A in Fig 4, in panels A and F in S4 Fig, and with the statistical analyses used to produce Fig 2. The authors have responded to these concerns, acknowledging that some errors were made in figure preparation and with some statistical tests, however a final resolution has not yet been reached, and the matter is being evaluated by the authors’ institution.
This Expression of Concern should not be considered as a statement regarding validity of the work but rather as a notification to readers, and an intent to provide additional information as it becomes available.
- 1. Ciaudo C, Jay F, Okamoto I, Chen C-J, Sarazin A, Servant N, et al. (2013) RNAi-Dependent and Independent Control of LINE1 Accumulation and Mobility in Mouse Embryonic Stem Cells. PLoS Genet 9(11): e1003791. pmid:24244175
Citation: The PLOS Genetics Editors (2015) Expression of Concern: RNAi-Dependent and Independent Control of LINE1 Accumulation and Mobility in Mouse Embryonic Stem Cells. PLoS Genet 11(6): e1005377. https://doi.org/10.1371/journal.pgen.1005377
Published: June 29, 2015
Copyright: © 2015 The PLOS Genetics Editors. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited