Figure 9 is incorrect. It contains components that are duplicated and do not correspond to what is stated in the figure legend or in the text. Specifically the Lepre1H662A/H662A gel in panel A is a duplication of the Lepre1+/+ gel, and the Lepre1+/+ lane in panel C is a duplication of the Lepre1H662A/H662A lane. The authors have provided a corrected version here. This corrected version corresponds to what is stated in the figure legend and in the text.
Analysis of procollagen secretion by the collagen pulse-chase assay suggests that the procollagen secreted from Lepre1H662A/H662Afibroblasts is similar to Lepre1+/+ fibroblasts (A, B). Additionally, there does not appear to be a decrease in the amount of procollagen secreted from the Lepre1H662A/H662A fibroblasts in comparison toLepre1+/+ fibroblasts (A, B). These findings are in contrast to that of the Crtap−/− fibroblasts, which have an increase in the rate of procollagen secretion (A). Collagen modification was assessed using the collagen steady-state assay. We observed no difference in the migration pattern of procollagen and collagen isolated from Lepre1+/+(+/+) and Lepre1H662A/H662A (H662A/H662A) fibroblasts (C). These assays were repeated three times.
Citation: The PLOS Genetics Staff (2014) Correction: Differential Effects of Collagen Prolyl 3-Hydroxylation on Skeletal Tissues. PLoS Genet 10(6): e1004473. https://doi.org/10.1371/journal.pgen.1004473
Published: June 3, 2014
Copyright: © 2014 The PLOS Genetics Staff. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.