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Correction: Differential Effects of Collagen Prolyl 3-Hydroxylation on Skeletal Tissues

  • The PLOS Genetics Staff

Correction: Differential Effects of Collagen Prolyl 3-Hydroxylation on Skeletal Tissues

  • The PLOS Genetics Staff
PLOS
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Figure 9 is incorrect. It contains components that are duplicated and do not correspond to what is stated in the figure legend or in the text. Specifically the Lepre1H662A/H662A gel in panel A is a duplication of the Lepre1+/+ gel, and the Lepre1+/+ lane in panel C is a duplication of the Lepre1H662A/H662A lane. The authors have provided a corrected version here. This corrected version corresponds to what is stated in the figure legend and in the text.

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Figure 9:. Lepre1H662A/H662A fibroblast procollagen secretion rate and collagen modification is normal.

Analysis of procollagen secretion by the collagen pulse-chase assay suggests that the procollagen secreted from Lepre1H662A/H662Afibroblasts is similar to Lepre1+/+ fibroblasts (A, B). Additionally, there does not appear to be a decrease in the amount of procollagen secreted from the Lepre1H662A/H662A fibroblasts in comparison toLepre1+/+ fibroblasts (A, B). These findings are in contrast to that of the Crtap−/− fibroblasts, which have an increase in the rate of procollagen secretion (A). Collagen modification was assessed using the collagen steady-state assay. We observed no difference in the migration pattern of procollagen and collagen isolated from Lepre1+/+(+/+) and Lepre1H662A/H662A (H662A/H662A) fibroblasts (C). These assays were repeated three times.

https://doi.org/10.1371/journal.pgen.1004121.g009

Reference

  1. 1. Homan EP, Lietman C, Grafe I, Lennington J, Morello R, et al. (2014) Differential Effects of Collagen Prolyl 3-Hydroxylation on Skeletal Tissues. PLoS Genet 10(1): e1004121