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PLoS Genetics Issue Image | Vol. 8(5) May 2012

PLoS Genetics Issue Image | Vol. 8(5) May 2012

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Inactivation of FAM20C leads to hypophosphatemic rickets.

The Sox2-Cre—mediated conditional knockout (cKO) of Fam20c leads to significant skeletal defects. X-ray imaging of 5-month-old cKO mice (right) shows smaller stature, distorted spine, and hypomineralized skeleton when compared with their wild type littermates (left). The skeletal defects along with lower phosphorus and higher FGF23 levels in the serum of cKO mice are consistent with a diagnosis of hypophosphatemic rickets, indicating that FAM20C plays an essential role in biomineralization and maintenance of total body phosphorus homeostasis. See Wang et al.

Image Credit: Xiaofang Wang (Texas A&M Health Science Center, Baylor College of Dentistry).

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Inactivation of FAM20C leads to hypophosphatemic rickets.

The Sox2-Cre—mediated conditional knockout (cKO) of Fam20c leads to significant skeletal defects. X-ray imaging of 5-month-old cKO mice (right) shows smaller stature, distorted spine, and hypomineralized skeleton when compared with their wild type littermates (left). The skeletal defects along with lower phosphorus and higher FGF23 levels in the serum of cKO mice are consistent with a diagnosis of hypophosphatemic rickets, indicating that FAM20C plays an essential role in biomineralization and maintenance of total body phosphorus homeostasis. See Wang et al.

Image Credit: Xiaofang Wang (Texas A&M Health Science Center, Baylor College of Dentistry).

https://doi.org/10.1371/image.pgen.v08.i05.g001