Figures
An eye-antennal imaginal disc containing TSC2 mutant clones.
Mutations in either TSC1 or TSC2 result in tuberous sclerosis, a rare genetic disease that causes benign tumors. In this issue of PLoS Genetics, Hsieh et al. report that TSC1 and TSC2 in Drosophila regulate dE2F1 protein expression and cooperate with RBF1 to control cellular survival and proliferation. This image is an eye-antennal imaginal disc that contains tsc2 mutant clones. In the tsc2 mutant clones (GFP negative), dE2F1 proteins (red) are expressed at a higher level compared to the neighboring wild type clones (GFP positive cells). The difference can be clearly seen in photoreceptors that are marked by ELAV (blue).
Image Credit: Ting-Chiu Hsieh and Nam-Sung Moon
Citation: (2010) PLoS Genetics Issue Image | Vol. 6(8) August 2010. PLoS Genet 6(8): ev06.i08. https://doi.org/10.1371/image.pgen.v06.i08
Published: August 26, 2010
Copyright: © 2010 Hsieh, Moon. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Mutations in either TSC1 or TSC2 result in tuberous sclerosis, a rare genetic disease that causes benign tumors. In this issue of PLoS Genetics, Hsieh et al. report that TSC1 and TSC2 in Drosophila regulate dE2F1 protein expression and cooperate with RBF1 to control cellular survival and proliferation. This image is an eye-antennal imaginal disc that contains tsc2 mutant clones. In the tsc2 mutant clones (GFP negative), dE2F1 proteins (red) are expressed at a higher level compared to the neighboring wild type clones (GFP positive cells). The difference can be clearly seen in photoreceptors that are marked by ELAV (blue).
Image Credit: Ting-Chiu Hsieh and Nam-Sung Moon