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Open Access
Peer-reviewed
Research Article
The derived allele of a novel intergenic variant at chromosome 11 associates with lower body mass index and a favorable metabolic phenotype in Greenlanders
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Mette K. Andersen,
Roles Conceptualization, Formal analysis, Writing – original draft, Writing – review & editing
Affiliation Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
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Emil Jørsboe,
Roles Formal analysis, Methodology, Writing – review & editing
Affiliation The Bioinformatics Centre, Department of Biology, University of Copenhagen, Copenhagen, Denmark
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Line Skotte,
Roles Data curation, Formal analysis, Writing – review & editing
Affiliation Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark
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Kristian Hanghøj,
Roles Formal analysis, Methodology, Writing – review & editing
Affiliation The Bioinformatics Centre, Department of Biology, University of Copenhagen, Copenhagen, Denmark
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Camilla H. Sandholt,
Roles Conceptualization, Writing – review & editing
Affiliation Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
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Ida Moltke,
Roles Formal analysis, Methodology, Writing – review & editing
Affiliation The Bioinformatics Centre, Department of Biology, University of Copenhagen, Copenhagen, Denmark
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Niels Grarup,
Roles Data curation, Writing – review & editing
Affiliation Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
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Timo Kern,
Roles Data curation, Writing – review & editing
Affiliation Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
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Yuvaraj Mahendran,
Roles Data curation, Writing – review & editing
Affiliations Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark, PEPperPRINT GmbH, Heidelberg, Germany
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Bolette Søborg,
Roles Data curation, Writing – review & editing
Affiliation Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark
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Peter Bjerregaard,
Roles Resources, Writing – review & editing
Affiliation National Institute of Public Health, University of Southern Denmark, Copenhagen, Denmark
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Christina V. L. Larsen,
Roles Data curation, Writing – review & editing
Affiliations National Institute of Public Health, University of Southern Denmark, Copenhagen, Denmark, Greenland Centre for Health Research, University of Greenland, Nuuk, Greenland
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Inger K. Dahl-Petersen,
Roles Data curation, Writing – review & editing
Affiliation National Institute of Public Health, University of Southern Denmark, Copenhagen, Denmark
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Hemant K. Tiwari,
Roles Formal analysis, Writing – review & editing
Affiliation Department of Biostatistics, School of Public Health, University of Alabama at Birmingham, Birmingham, Alabama, United States of America
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Bjarke Feenstra,
Roles Formal analysis, Resources, Writing – review & editing
Affiliation Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark
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Anders Koch,
Roles Resources, Writing – review & editing
Affiliations Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark, Greenland Centre for Health Research, University of Greenland, Nuuk, Greenland, Department of Infectious Diseases, Rigshospitalet University Hospital, Copenhagen, Denmark
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Howard W. Wiener,
Roles Formal analysis, Writing – review & editing
Affiliation Department of Epidemiology, School of Public Health, University of Alabama at Birmingham, Birmingham, Alabama, United States of America
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Scarlett E. Hopkins,
Roles Resources, Writing – review & editing
Affiliations Department of Obstetrics and Gynecology, Center for Developmental Health, Knight Cardiovascular Institute, Oregon Health & Science University, Portland, Oregon, United States of America, Center for Alaska Native Health Research, University of Alaska Fairbanks, Fairbanks, Alaska, United States of America
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Oluf Pedersen,
Roles Resources, Supervision, Writing – review & editing
Affiliation Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
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Mads Melbye,
Roles Resources, Writing – review & editing
Affiliations Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark, Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark, Department of Medicine, Stanford University School of Medicine, Stanford, California, United States of America
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Bert B. Boyer,
Roles Resources, Writing – review & editing
Affiliations Department of Obstetrics and Gynecology, Center for Developmental Health, Knight Cardiovascular Institute, Oregon Health & Science University, Portland, Oregon, United States of America, Center for Alaska Native Health Research, University of Alaska Fairbanks, Fairbanks, Alaska, United States of America
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Marit E. Jørgensen,
Roles Resources, Supervision, Writing – review & editing
Affiliations National Institute of Public Health, University of Southern Denmark, Copenhagen, Denmark, Greenland Centre for Health Research, University of Greenland, Nuuk, Greenland, Steno Diabetes Center Copenhagen, Gentofte, Denmark
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Anders Albrechtsen ,
Roles Conceptualization, Formal analysis, Methodology, Supervision, Writing – review & editing
* E-mail: albrecht@binf.ku.dk (AA); torben.hansen@sund.ku.dk (TH)
¶‡ These authors are joint authors on this work.
Affiliation The Bioinformatics Centre, Department of Biology, University of Copenhagen, Copenhagen, Denmark
⨯ - [ ... ],
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Torben Hansen
Roles Conceptualization, Resources, Supervision, Writing – review & editing
* E-mail: albrecht@binf.ku.dk (AA); torben.hansen@sund.ku.dk (TH)
¶‡ These authors are joint authors on this work.
Affiliations Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark, Faculty of Health Sciences, University of Southern Denmark, Odense, Denmark
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The derived allele of a novel intergenic variant at chromosome 11 associates with lower body mass index and a favorable metabolic phenotype in Greenlanders
- Mette K. Andersen,
- Emil Jørsboe,
- Line Skotte,
- Kristian Hanghøj,
- Camilla H. Sandholt,
- Ida Moltke,
- Niels Grarup,
- Timo Kern,
- Yuvaraj Mahendran,
- Bolette Søborg
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- Published: January 24, 2020
- https://doi.org/10.1371/journal.pgen.1008544