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Open Access
Peer-reviewed
Research Article
The Association of a SNP Upstream of INSIG2 with Body Mass Index is Reproduced in Several but Not All Cohorts
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Helen N Lyon ,
Contributed equally to this work with: Helen N Lyon, Valur Emilsson, Anke Hinney, Iris M Heid, Jessica Lasky-Su, Xiaofeng Zhu
*To whom correspondence should be addressed. E-mail: helen.lyon@childrens.harvard.edu
Affiliations Program in Genomics, Divisions of Genetics and Endocrinology, Children's Hospital, Boston, Massachusetts , Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, Massachusetts , Department of Pediatrics, Harvard Medical School, Boston, Massachusetts
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Valur Emilsson ,
Contributed equally to this work with: Helen N Lyon, Valur Emilsson, Anke Hinney, Iris M Heid, Jessica Lasky-Su, Xiaofeng Zhu
Affiliation deCODE genetics, Reykjavik, Iceland
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Anke Hinney ,
Contributed equally to this work with: Helen N Lyon, Valur Emilsson, Anke Hinney, Iris M Heid, Jessica Lasky-Su, Xiaofeng Zhu
Affiliation Department of Child and Adolescent Psychiatry, Rheinische Kliniken Essen, University of Duisburg-Essen, Essen, Germany
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Iris M Heid ,
Contributed equally to this work with: Helen N Lyon, Valur Emilsson, Anke Hinney, Iris M Heid, Jessica Lasky-Su, Xiaofeng Zhu
Affiliations Institute of Epidemiology, GSF-National Research Centre for Environment and Health, Neuherberg, Germany , Institute of Medical Informatics, Biometry, and Epidemiology, Ludwig-Maximilians-Universität München, Munich, Germany
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Jessica Lasky-Su ,
Contributed equally to this work with: Helen N Lyon, Valur Emilsson, Anke Hinney, Iris M Heid, Jessica Lasky-Su, Xiaofeng Zhu
Affiliations Channing Laboratory, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America , State University of New York Upstate Medical University, Syracuse, New York, United States of America
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Xiaofeng Zhu ,
Contributed equally to this work with: Helen N Lyon, Valur Emilsson, Anke Hinney, Iris M Heid, Jessica Lasky-Su, Xiaofeng Zhu
Affiliation Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, Ohio, United States of America
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Gudmar Thorleifsson,
Affiliation deCODE genetics, Reykjavik, Iceland
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Steinunn Gunnarsdottir,
Affiliation deCODE genetics, Reykjavik, Iceland
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G. Bragi Walters,
Affiliation deCODE genetics, Reykjavik, Iceland
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Unnur Thorsteinsdottir,
Affiliation deCODE genetics, Reykjavik, Iceland
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Augustine Kong,
Affiliation deCODE genetics, Reykjavik, Iceland
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Jeffrey Gulcher,
Affiliation deCODE genetics, Reykjavik, Iceland
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Thuy Trang Nguyen,
Affiliations Institute of Medical Biometry and Epidemiology, Philipps-University of Marburg, Marburg, Germany , Department of Clinical Psychology and Psychotherapy, Philipps-University of Marburg, Marburg, Germany
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André Scherag,
Affiliations Institute of Medical Biometry and Epidemiology, Philipps-University of Marburg, Marburg, Germany , Department of Clinical Psychology and Psychotherapy, Philipps-University of Marburg, Marburg, Germany
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Arne Pfeufer,
Affiliations Institute of Human Genetics, Technical University Munich, Munich, Germany , Institute of Human Genetics, GSF-National Research Center for Environment and Health, Genome Analysis Center, Neuherberg, Germany
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Thomas Meitinger,
Affiliations Institute of Human Genetics, Technical University Munich, Munich, Germany , Institute of Human Genetics, GSF-National Research Center for Environment and Health, Genome Analysis Center, Neuherberg, Germany
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Günter Brönner,
Affiliation Department of Child and Adolescent Psychiatry, Rheinische Kliniken Essen, University of Duisburg-Essen, Essen, Germany
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Winfried Rief,
Affiliations Institute of Medical Biometry and Epidemiology, Philipps-University of Marburg, Marburg, Germany , Department of Clinical Psychology and Psychotherapy, Philipps-University of Marburg, Marburg, Germany
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Manuel E Soto-Quiros,
Affiliation Division of Pediatric Pulmonology, Hospital Nacional de Niños, San José, Costa Rica
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Lydiana Avila,
Affiliation Division of Pediatric Pulmonology, Hospital Nacional de Niños, San José, Costa Rica
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Barbara Klanderman,
Affiliation Channing Laboratory, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America
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Benjamin A Raby,
Affiliation Channing Laboratory, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America
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Edwin K Silverman,
Affiliation Channing Laboratory, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America
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Scott T Weiss,
Affiliation Channing Laboratory, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America
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Nan Laird,
Affiliation Channing Laboratory, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America
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Xiao Ding,
Affiliation Channing Laboratory, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America
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Leif Groop,
Affiliations Department of Endocrinology, University Hospital MAS, Lund University, Malmö, Sweden , Department of Medicine, Helsinki University Central Hospital, University of Helsinki, Helsinki, Finland , Research Program for Molecular Medicine, University of Helsinki, Helsinki, Finland
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Tiinamaija Tuomi,
Affiliations Department of Medicine, Helsinki University Central Hospital, University of Helsinki, Helsinki, Finland , Research Program for Molecular Medicine, University of Helsinki, Helsinki, Finland , Folkhalsan Research Center, Helsinki, Finland
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Bo Isomaa,
Affiliation Folkhalsan Research Center, Helsinki, Finland
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Kristina Bengtsson,
Affiliations Department of Medicine, Helsinki University Central Hospital, University of Helsinki, Helsinki, Finland , Research Program for Molecular Medicine, University of Helsinki, Helsinki, Finland
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Johannah L Butler,
Affiliations Program in Genomics, Divisions of Genetics and Endocrinology, Children's Hospital, Boston, Massachusetts , Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, Massachusetts
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Richard S Cooper,
Affiliation Department of Preventive Medicine and Epidemiology, Loyola University Medical Center, Maywood, Illinois, United States of America
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Caroline S Fox,
Affiliation Framingham Heart Study, National Heart, Lung and Blood Institute, Framingham, Massachusetts, United States of America
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Christopher J O'Donnell,
Affiliation Framingham Heart Study, National Heart, Lung and Blood Institute, Framingham, Massachusetts, United States of America
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Caren Vollmert,
Affiliation Institute of Epidemiology, GSF-National Research Centre for Environment and Health, Neuherberg, Germany
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Juan C Celedón,
Affiliation Channing Laboratory, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America
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H. Erich Wichmann,
Affiliations Institute of Epidemiology, GSF-National Research Centre for Environment and Health, Neuherberg, Germany , Institute of Medical Informatics, Biometry, and Epidemiology, Ludwig-Maximilians-Universität München, Munich, Germany
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Johannes Hebebrand,
Affiliation Department of Child and Adolescent Psychiatry, Rheinische Kliniken Essen, University of Duisburg-Essen, Essen, Germany
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Kari Stefansson,
Affiliation deCODE genetics, Reykjavik, Iceland
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Christoph Lange,
Affiliation Channing Laboratory, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America
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Joel N Hirschhorn
Affiliations Program in Genomics, Divisions of Genetics and Endocrinology, Children's Hospital, Boston, Massachusetts , Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, Massachusetts , Department of Genetics, Harvard Medical School, Boston, Massachusetts, United States of America
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The Association of a SNP Upstream of INSIG2 with Body Mass Index is Reproduced in Several but Not All Cohorts
- Helen N Lyon,
- Valur Emilsson,
- Anke Hinney,
- Iris M Heid,
- Jessica Lasky-Su,
- Xiaofeng Zhu,
- Gudmar Thorleifsson,
- Steinunn Gunnarsdottir,
- G. Bragi Walters,
- Unnur Thorsteinsdottir

- Published: April 27, 2007
- https://doi.org/10.1371/journal.pgen.0030061