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Table S8. DNA sequence analysis of the bypass event type across TT CPD, TT 6-4 PP, and cisPt-GG adduct in Usp1+/+, Usp1-/-, Usp1-/- + WT Usp1 and Usp1-/- + Usp1 C90S MEFs.
TT CPDUsp1+/+Usp1-/-Nucleotide inserted opposite lesionNumber of isolates (%)C-AA-C25 (52)33 (72)Non-TLS events23 (48)13 (28)Total clones analyzed:48 (100)46 (100)Accurate TLS frequency, %100100Mutagenic TLS frequency, %<4<3TT 6-4 PPUsp1+/+Usp1-/-Nucleotide inserted opposite lesionNumber of isolates (%)C-A A - C 6 1 ( 6 4 ) 4 8 ( 5 1 ) C - C A - C - 1 ( 1 ) C - T A - C - 1 ( 1 ) C - A T - C - 1 ( 1 ) C - A A - A 5 ( 5 ) 1 0 ( 1 1 ) A - A A - A - 1 ( 1 ) C - G A - A 2 ( 2 ) - C - A - C 1 1 ( 1 2 ) 8 ( 8 ) N o n - T L S e v e n t s 1 6 ( 1 7 ) 2 4 ( 2 6 ) T o t a l c l o n e s a n a l y z e d : 9 5 ( 1 0 0 ) 9 4 ( 1 0 0 ) A c c u r a t e T L S f r e q u e n c y , % 7 7 6 8 T a r geted mutagenic TLS frequency, %1416Semi-targeted mutagenic TLS frequency, %616Mixed mutagenic TLS frequency, %3<1.4CisPt-GGUsp1+/+Usp1-/-Nucleotide inserted opposite lesionNumber of isolates (%)G-CC-T31 (54)56 (70)G-AC-T4 (7)10 (13)G-GC-T-1 (1)G-TC-T-1 (1)G-CC-A-1 (1)G-CA-A-1 (1)G-AG-A-1 (1)Non-TLS events22 (39)9 (11)Total clones analyzed57 (100)80 (100)Accurate TLS frequency, %8979Mutagenic TLS frequency, %1121CisPt-GGUsp1-/- + WT Usp1Usp1-/- + Usp1 C90SNucleotide inserted opposite lesionNumber of isolates (%)G-CC-T37 (77)31 (66)G-AC-T4 (8)3 (6)G-CC-C-1 (2)Non-TLS events7 (15)12 (26)Total clones analyzed48 (100)47 (100)
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