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Sunji Lee, Hong Bao, Zachary Ishikawa, Weidong Wang, Hui-Ying Lim
Cardiomyocyte Regulation of Systemic Lipid Metabolism by the Apolipoprotein B-Containing Lipoproteins in Drosophila
www.plosgenetics.org
www.plosgenetics.org
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(remain)Tj
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-32.0426 -1.3039 Td
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([)Tj
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(20)Tj
0 g
(],)Tj
2.0749 0 Td
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-35.5745 -1.2983 Td
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(involved)Tj
3.651 0 Td
(in)Tj
1.0318 0 Td
(the)Tj
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(biosynthesis)Tj
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(secretion)Tj
3.8437 0 Td
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2.2054 0 Td
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(heart)Tj
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(21)Tj
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(,)Tj
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1.7348 0 Td
(22)Tj
0 g
(].)Tj
-35.3251 -1.2982 Td
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4.0761 0 Td
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1.576 0 Td
(clear)Tj
2.1147 0 Td
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(derived)Tj
3.2144 0 Td
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(the)Tj
1.4683 0 Td
(heart)Tj
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(could)Tj
2.4492 0 Td
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(to)Tj
1.0262 0 Td
(influ-)Tj
-35.2174 -1.2983 Td
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(systemic)Tj
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(lipid)Tj
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1.6725 0 Td
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1.4741 0 Td
[()-4()20()7()-3()11()10()18()4()4( )]TJ
/F8 1 Tf
4.507 0 Td
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2.965 0 Td
(we)Tj
1.3266 0 Td
(reveal)Tj
2.5739 0 Td
(that)Tj
1.7801 0 Td
(the)Tj
1.4684 0 Td
(cardiomyocytes)Tj
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(a)Tj
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1.7802 0 Td
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1.9672 0 Td
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2.2564 0 Td
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1.2019 0 Td
(equally)Tj
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4.388 0 Td
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1.0148 0 Td
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1.2415 0 Td
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(counterparts)Tj
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(in)Tj
1.0374 0 Td
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1.4684 0 Td
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5.3914 0 Td
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(homeostasis)Tj
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3.1464 0 Td
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(\(HFD\),)Tj
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-36.2095 -1.2982 Td
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1.4683 0 Td
(predominant)Tj
5.4822 0 Td
(determinants)Tj
5.5445 0 Td
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1.0148 0 Td
(whole-body)Tj
4.9549 0 Td
(lipid)Tj
2.0466 0 Td
(metabolism.)Tj
5.125 0 Td
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1.8652 0 Td
(results)Tj
2.812 0 Td
(further)Tj
3.0273 0 Td
(show)Tj
2.3018 0 Td
(that)Tj
-35.6426 -1.2983 Td
(HFD)Tj
2.2506 0 Td
(differentially)Tj
5.3065 0 Td
(alters)Tj
2.3527 0 Td
(relative)Tj
3.1351 0 Td
(Mtp)Tj
1.9332 0 Td
(and)Tj
1.7291 0 Td
(apoLpp)Tj
3.2485 0 Td
(gene)Tj
2.0806 0 Td
(expression)Tj
4.4674 0 Td
(in)Tj
1.0375 0 Td
(the)Tj
1.4683 0 Td
(fat)Tj
1.2416 0 Td
(body)Tj
2.2167 0 Td
(and)Tj
1.7291 0 Td
(cardio-)Tj
-34.1969 -1.3039 Td
(myocytes,)Tj
4.1839 0 Td
(culminating)Tj
5.0683 0 Td
(in)Tj
1.0374 0 Td
(their)Tj
2.109 0 Td
(higher)Tj
2.8006 0 Td
(levels)Tj
2.3754 0 Td
(in)Tj
1.0375 0 Td
(the)Tj
1.4684 0 Td
(cardiomyocytes)Tj
6.4913 0 Td
(than)Tj
2.0295 0 Td
(in)Tj
1.0375 0 Td
(the)Tj
1.4684 0 Td
(fat)Tj
1.2415 0 Td
(body)Tj
2.2167 0 Td
(and)Tj
-34.5654 -1.2983 Td
(possibly)Tj
3.4412 0 Td
(underpinning)Tj
5.7826 0 Td
(the)Tj
1.4684 0 Td
(differential)Tj
4.6034 0 Td
(contribution)Tj
5.2894 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.4684 0 Td
(cardiomyocyte-)Tj
6.4856 0 Td
(versus)Tj
2.7156 0 Td
(fat)Tj
1.2415 0 Td
(body-)Tj
-33.5109 -1.2983 Td
(derived)Tj
3.2144 0 Td
(apoB-lipoproteins)Tj
7.4381 0 Td
(on)Tj
1.2756 0 Td
(systemic)Tj
3.6283 0 Td
(lipid)Tj
2.0466 0 Td
(metabolic)Tj
4.1499 0 Td
(regulation)Tj
4.3086 0 Td
(under)Tj
2.6192 0 Td
(HFD)Tj
2.2507 0 Td
(conditions.)Tj
ET
Q
q
1 j
1 J
0 w
11.9999 0 0 11.9999 200.0125 339.9874 cm
BT
/F3 1 Tf
1 TL
-0.0033 Tc
0 0 Td
(Results)Tj
3.7984 0 Td
(and)Tj
1.989 0 Td
(Discussion)Tj
/F0 1 Tf
-5.7874 -1.4976 Td
(Genetic)Tj
3.6283 0 Td
(screening)Tj
4.5024 0 Td
(identifies)Tj
4.1103 0 Td
(Mtp)Tj
1.8756 0 Td
(as)Tj
1.2614 0 Td
(a)Tj
0.7701 0 Td
(key)Tj
1.7575 0 Td
(modulator)Tj
4.6158 0 Td
(of)Tj
1.0441 0 Td
(lipid)Tj
1.9654 0 Td
(metabolism)Tj
-25.5309 -1.1669 Td
(in)Tj
0.9826 0 Td
(response)Tj
4.2851 0 Td
(to)Tj
1.0441 0 Td
(a)Tj
0.7701 0 Td
(high-fat)Tj
3.5103 0 Td
(diet)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 200.0125 291.0047 cm
BT
/F8 1 Tf
1 TL
-0.004 Tc
0 0 Td
(To)Tj
1.3322 0 Td
(identify)Tj
3.2882 0 Td
(genes)Tj
2.4378 0 Td
(involved)Tj
3.6453 0 Td
(in)Tj
1.0318 0 Td
(the)Tj
1.4627 0 Td
(regulation)Tj
4.3029 0 Td
(of)Tj
1.0148 0 Td
(lipid)Tj
2.041 0 Td
(metabolism,)Tj
5.1193 0 Td
(we)Tj
1.3266 0 Td
(performed)Tj
4.4617 0 Td
(a)Tj
0.652 0 Td
(haplo-insuffi-)Tj
-32.1163 -1.2982 Td
(ciency)Tj
2.7552 0 Td
(screen)Tj
2.7723 0 Td
(for)Tj
1.3833 0 Td
(genes)Tj
2.4378 0 Td
(that)Tj
1.7744 0 Td
(could)Tj
2.4491 0 Td
(alter)Tj
1.99 0 Td
(the)Tj
1.4683 0 Td
(pathogenesis)Tj
5.3518 0 Td
(of)Tj
1.0091 0 Td
(HFD-induced)Tj
5.845 0 Td
(obesity)Tj
3.0387 0 Td
(in)Tj
/F14 1 Tf
1.0318 0 Td
[()-4()20()7()-3()11()10()18()4()4( )]TJ
/F8 1 Tf
-33.3068 -1.3039 Td
(\()Tj
0.83 0.64 0.02 0 k
(S1A)Tj
2.194 0 Td
(Fig)Tj
0 g
(\).)Tj
2.0466 0 Td
(We)Tj
1.61 0 Td
(first)Tj
1.8028 0 Td
(developed)Tj
4.2747 0 Td
(a)Tj
0.6519 0 Td
(feeding)Tj
3.1635 0 Td
(regimen)Tj
3.5376 0 Td
(in)Tj
1.0375 0 Td
(which)Tj
2.6475 0 Td
(control)Tj
/F14 1 Tf
3.1238 0 Td
[()]TJ
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 467.5464 269.4614 cm
BT
/F14 1 Tf
1 TL
-0.0053 Tc
0 0 Td
[(\r\r\r)]TJ
ET
Q
q
1 j
1 J
0 w
10 0 0 10 483.6472 264.9826 cm
BT
/F8 1 Tf
1 TL
-0.004 Tc
0 0 Td
(female)Tj
2.8573 0 Td
(and)Tj
1.7291 0 Td
(male)Tj
2.143 0 Td
(flies)Tj
-35.0926 -1.2982 Td
(were)Tj
2.1146 0 Td
(reared)Tj
2.7609 0 Td
(on)Tj
1.2699 0 Td
(a)Tj
0.6463 0 Td
(NFD)Tj
2.211 0 Td
(or)Tj
1.0942 0 Td
(a)Tj
0.6463 0 Td
(HFD)Tj
2.245 0 Td
(\(~48%)Tj
2.8403 0 Td
(of)Tj
1.0092 0 Td
(the)Tj
1.457 0 Td
(calories)Tj
3.2484 0 Td
(derived)Tj
3.2088 0 Td
(from)Tj
2.1997 0 Td
(Crisco)Tj
2.8062 0 Td
(hydrogenated)Tj
5.7203 0 Td
(vege-)Tj
-35.4781 -1.2983 Td
(table)Tj
2.1259 0 Td
(oils\))Tj
1.9446 0 Td
(\()Tj
0.83 0.64 0.02 0 k
(S1B)Tj
2.0919 0 Td
(and)Tj
1.7292 0 Td
(S1B)Tj
ET
Q
q
0.83 0.64 0.02 0 k
1 j
1 J
0 w
6.9998 0 0 6.9998 294.2362 242.6456 cm
BT
/F15 1 Tf
1 TL
0 0 Td
(0)Tj
ET
Q
q
0.83 0.64 0.02 0 k
1 j
1 J
0 w
10 0 0 10 298.8283 239.0173 cm
BT
/F8 1 Tf
1 TL
-0.004 Tc
0 0 Td
(Fig)Tj
0 g
(\))Tj
1.8198 0 Td
(until)Tj
2.1089 0 Td
(adult)Tj
2.2507 0 Td
(eclosion.)Tj
3.7304 0 Td
(Measurement)Tj
5.743 0 Td
(of)Tj
1.0148 0 Td
(whole-body)Tj
4.9549 0 Td
(triglyceride)Tj
-31.504 -1.3039 Td
(\(TG\))Tj
2.2281 0 Td
(levels)Tj
2.3754 0 Td
(in)Tj
1.0318 0 Td
(the)Tj
1.4683 0 Td
(newly)Tj
2.5795 0 Td
(eclosed)Tj
3.135 0 Td
(adults)Tj
2.6136 0 Td
(revealed)Tj
3.5206 0 Td
(a)Tj
0.6576 0 Td
(significant)Tj
4.388 0 Td
(increase)Tj
3.4696 0 Td
(\(~1.5)Tj
2.3187 0 Td
(fold\))Tj
2.126 0 Td
(in)Tj
1.0375 0 Td
(TG)Tj
1.5477 0 Td
(levels)Tj
-34.4974 -1.2982 Td
(in)Tj
1.0318 0 Td
(HFD-reared)Tj
5.1534 0 Td
(compared)Tj
4.2462 0 Td
(to)Tj
1.0261 0 Td
(the)Tj
1.4683 0 Td
(NFD-reared)Tj
5.125 0 Td
(progeny)Tj
3.5036 0 Td
(\()Tj
0.83 0.64 0.02 0 k
(S1C)Tj
2.177 0 Td
(Fig)Tj
0 g
(\).)Tj
2.0466 0 Td
(Consistent)Tj
4.4958 0 Td
(with)Tj
1.9955 0 Td
(that,)Tj
2.007 0 Td
(Nile)Tj
-34.2763 -1.2983 Td
(Red)Tj
1.7915 0 Td
(staining)Tj
3.4072 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.474 0 Td
(fat)Tj
1.2359 0 Td
(body)Tj
2.2166 0 Td
(revealed)Tj
3.5263 0 Td
(that)Tj
1.7801 0 Td
(control)Tj
/F14 1 Tf
3.1181 0 Td
[()]TJ
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 402.2929 204.4346 cm
BT
/F14 1 Tf
1 TL
-0.0053 Tc
0 0 Td
[(\r\r\r)]TJ
ET
Q
q
1 j
1 J
0 w
10 0 0 10 418.4503 200.0125 cm
BT
/F8 1 Tf
1 TL
-0.004 Tc
0 0 Td
(HFD-fed)Tj
3.838 0 Td
(larvae)Tj
2.5852 0 Td
(had)Tj
1.7121 0 Td
(increased)Tj
3.9969 0 Td
(neutral)Tj
-33.9758 -1.3039 Td
(lipid)Tj
2.0466 0 Td
(accumulation)Tj
5.6749 0 Td
(\()Tj
0.83 0.64 0.02 0 k
(S1D)Tj
2.2451 0 Td
(Fig)Tj
0 g
(,)Tj
1.7064 0 Td
(arrows\))Tj
3.2882 0 Td
(in)Tj
1.0374 0 Td
(the)Tj
1.4684 0 Td
(adipocytes)Tj
4.4332 0 Td
(\()Tj
0.83 0.64 0.02 0 k
(S1D)Tj
2.2507 0 Td
(Fig)Tj
0 g
(,)Tj
1.7065 0 Td
(outlines\))Tj
3.736 0 Td
(compared)Tj
4.2463 0 Td
(to)Tj
1.0261 0 Td
(NFD-)Tj
-34.8658 -1.2982 Td
(fed)Tj
1.457 0 Td
(larvae.)Tj
2.812 0 Td
(Collectively,)Tj
5.0966 0 Td
(these)Tj
2.2564 0 Td
(data)Tj
1.9105 0 Td
(provide)Tj
3.2882 0 Td
(evidence)Tj
3.7134 0 Td
(that)Tj
1.78 0 Td
(our)Tj
1.6271 0 Td
(HFD)Tj
2.2507 0 Td
(feeding)Tj
3.1634 0 Td
(regimen)Tj
3.5376 0 Td
(generates)Tj
3.9685 0 Td
(a)Tj
/F14 1 Tf
-36.8614 -1.2983 Td
[()-4()20()7()-3()11()10()18()4()4( )]TJ
/F8 1 Tf
4.5071 0 Td
(model)Tj
2.7439 0 Td
(of)Tj
1.0148 0 Td
(diet-induced)Tj
5.3348 0 Td
(obesity.)Tj
-12.4044 -1.2983 Td
(Using)Tj
2.6022 0 Td
(the)Tj
1.4683 0 Td
(same)Tj
2.2564 0 Td
(feeding)Tj
3.1635 0 Td
(regimen)Tj
3.5376 0 Td
(to)Tj
1.0261 0 Td
(screen)Tj
2.7723 0 Td
(a)Tj
0.6576 0 Td
(collection)Tj
4.1101 0 Td
(of)Tj
1.0148 0 Td
(deficiency)Tj
4.2633 0 Td
(lines,)Tj
2.296 0 Td
(we)Tj
1.3266 0 Td
(identified)Tj
-31.691 -1.3039 Td
(three)Tj
2.262 0 Td
(overlapping)Tj
4.972 0 Td
(deficiency)Tj
4.2689 0 Td
(lines,)Tj
/F14 1 Tf
2.2904 0 Td
[()-7(\r)]TJ
/F8 1 Tf
(,)Tj
/F14 1 Tf
6.1511 0 Td
[()-7()]TJ
/F8 1 Tf
(,)Tj
6.0944 0 Td
(and)Tj
/F14 1 Tf
1.7291 0 Td
[()-7()-16()-4()15()]TJ
/F8 1 Tf
6.3269 0 Td
(within)Tj
-34.0948 -1.2982 Td
(chromosome)Tj
5.4878 0 Td
(2L)Tj
1.2303 0 Td
(that)Tj
1.7801 0 Td
(displayed)Tj
3.9798 0 Td
(significant)Tj
4.388 0 Td
(decreases)Tj
3.9685 0 Td
(in)Tj
1.0374 0 Td
(TG)Tj
1.542 0 Td
(levels)Tj
2.3755 0 Td
(compared)Tj
4.2462 0 Td
(to)Tj
1.0262 0 Td
(control)Tj
/F14 1 Tf
3.1237 0 Td
[()]TJ
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 548.5039 126.4251 cm
BT
/F14 1 Tf
1 TL
-0.0053 Tc
0 0 Td
[(\r\r\r)]TJ
ET
Q
q
1 j
1 J
0 w
10 0 0 10 200.0125 109.0204 cm
BT
/F8 1 Tf
1 TL
-0.004 Tc
0 0 Td
(flies)Tj
1.8028 0 Td
(on)Tj
1.2756 0 Td
(HFD)Tj
2.2507 0 Td
(\()Tj
0.83 0.64 0.02 0 k
(Fig)Tj
1.8198 0 Td
(1A)Tj
1.3833 0 Td
(and)Tj
1.7291 0 Td
(1B)Tj
0 g
(\).)Tj
1.8425 0 Td
(Moreover,)Tj
4.3937 0 Td
(the)Tj
1.4683 0 Td
(TG)Tj
1.5477 0 Td
(levels)Tj
2.3754 0 Td
(in)Tj
1.0375 0 Td
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