Pleiotropy and epistasis within and between signaling pathways defines the genetic architecture of fungal virulence
Fig 9
Variation in hydrogen peroxide sensitivity.
QTL analysis of variation in response to hydrogen peroxide. A) Example growth phenotypes and scores of C. deneoformans segregants grown on media with hydrogen peroxide. B) Histogram of hydrogen peroxide growth scores. Growth scores of parental strains are marked by vertical lines. C) Manhattan plot of the association between genotype and growth in response to hydrogen peroxide. The x-axis represents chromosomal locations of haploblocks and the y-axis represents the strength in association between genotype and variation in growth score. D) Hydrogen peroxide growth scores (y-axis) as a function of allele at the peak of chromosome 12 (left) and chromosome 14 (right) QTL. Blue and orange triangles mark the parental phenotypes, black horizontal lines denote the average phenotypes of segregants by allele, and red lines are regression models relating the genotype to phenotype. The heritablity at each locus is estimated from these models and annotated in black.