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Pleiotropy and epistasis within and between signaling pathways defines the genetic architecture of fungal virulence

Fig 3

C. deneoformans growth curves.

Parental strains and progeny were assayed for growth across combinations of temperatures (rows) 30°, 37°, 39°C and concentrations of amphotericin B (columns) at 0.0, 0.075, 0.125, and 0.175 μg/ml. Optical density (OD595nm, y-axis) was measured every 15 minutes for 72 hours (x-axis). The median optical density across replicates is shown for the parental strains, XL280a (blue curve) and 431α (orange curve), and the F1 segregants (grey curves).

Fig 3