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Integrative QTL analysis of gene expression and chromatin accessibility identifies multi-tissue patterns of genetic regulation

Fig 6

Simple mediation models for the genetic regulation of gene expression.

(A) Mediation of the local-eQTL through chromatin accessibility in the region of the gene is consistent with genetic variation influencing the accessibility of gene j to the transcriptional machinery. (B) Mediation of distal-eQTL through the transcription of genes local to the QTL could be explained by transcription factor activity.

Fig 6

doi: https://doi.org/10.1371/journal.pgen.1008537.g006