Integrating predicted transcriptome from multiple tissues improves association detection
This figure compares S-MultiXcan to MultiXcan in four UK Biobank phenotypes. GTEx individuals were used as a reference panel for estimating expression correlation in the study population. The summary data-based method shows a good level of agreement with the individual-based method. In cases where the LD-structure between reference and study cohorts is mismatched, the summary-based method becomes less accurate. For example in Asthma, two genes are overestimated; however it tends to be conservative for most genes.