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Genotype to phenotype: Diet-by-mitochondrial DNA haplotype interactions drive metabolic flexibility and organismal fitness

Fig 11

The polyol pathway is upregulated in Dahomey larvae fed the 1:16 P:C diet.

(A) Expression of N and CrebB differed when larvae were fed the control (sucrose) diet, or sorbitol was the dietary sugar, but differences were lost when Epalrestat was added to the diet (n = 6 rep/mitotype, with n = 8 for Epalrestat fed Dahomey). (B) Food eaten was higher in Dahomey larvae than in Alstonville larvae. Food consumption increased when sorbitol was the dietary sugar and decreased when Epalrestat was added to the diet (n = 12 larvae/mitotype/diet were added to dye labelled food. Larvae with food visible in guts were collected and analysed: control-Alstonville = 7 larvae, control-Dahomey = 9 larvae, sorbitol-Alstonville = 8 larvae, sorbitol-Dahomey = 11 larvae, Epalrestat-both mitotypes = 10 larvae. Bars show mean ± s.e.m. * p< 0.05 and ** p< 0.01, as calculated by t-tests (see text).

Fig 11

doi: https://doi.org/10.1371/journal.pgen.1007735.g011