Genotype to phenotype: Diet-by-mitochondrial DNA haplotype interactions drive metabolic flexibility and organismal fitness
(A) The V161L site on TM6 was predicted to slow the cycling of the proton pump. The shorter arrow indicates the movement of TM5 as the Helix HL moves. (B) The mutation of site 161 from valine (left panel) to leucine (right panel) likely increases steric hindrance with tyrosine 184, narrowing the proton channel. (C) The secondary structure of the GTPase center in the lrRNA of D. melanogaster showing the site of mutation and structurally related residues.