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A General Approach for Haplotype Phasing across the Full Spectrum of Relatedness

Figure 5

Inferred gene flow by Merlin (purple) and our method (grey) for ten informative meioses on chromosome 10 taken from Val Borbera cohort pedigrees.

The light and dark purple represent genetic material from the grand-paternal and grand-maternal chromosomes (as inferred by Merlin's Viterbi algorithm), hence changing from light to dark implies a a recombination event. The grey rectangles contain the posterior probability (in black) of recombination from our method. The two methods broadly agree, although Merlin has inferred a number of implausibly small cross over events.

Figure 5