Coherent Functional Modules Improve Transcription Factor Target Identification, Cooperativity Prediction, and Disease Association
Transcription factors (blue) are connected to diseases (red) through modules in this bipartite graph. Prominent clusters of diseases are highlighted, as well as some highly-connected transcription factors. Importantly, STAT3 is connected to many fibrotic diseases, while E2F1 and E2F4 are connected to breast and ovarian cancer. (A): Expression of MEF2A and the projection of module 262 are significantly predictive of disease state. Individuals are ranked by their combined score (sum of normalized expression and module projection). (B): ROC curve for prediction of Crohn's disease from MEF2A expression, module 262 projection, and combined metric.