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Coherent Functional Modules Improve Transcription Factor Target Identification, Cooperativity Prediction, and Disease Association

Figure 5

Regulatory network of human disease.

Transcription factors (blue) are connected to diseases (red) through modules in this bipartite graph. Prominent clusters of diseases are highlighted, as well as some highly-connected transcription factors. Importantly, STAT3 is connected to many fibrotic diseases, while E2F1 and E2F4 are connected to breast and ovarian cancer. (A): Expression of MEF2A and the projection of module 262 are significantly predictive of disease state. Individuals are ranked by their combined score (sum of normalized expression and module projection). (B): ROC curve for prediction of Crohn's disease from MEF2A expression, module 262 projection, and combined metric.

Figure 5

doi: https://doi.org/10.1371/journal.pgen.1004122.g005