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Coherent Functional Modules Improve Transcription Factor Target Identification, Cooperativity Prediction, and Disease Association

Figure 4

Transcription factor interaction network reveals functional and disease sub-networks.

Transcription factors are connected solely on the basis of the similarity of the modules that they regulate. Transcription factors are colored according to a selection of diseases; (A, green): AIDS; (B, blue): arrhythmia; (C, pink): breast cancer; (D, red): hemorrhage. Nodes are annotated with strong (dashed black borders) and weak (solid grey borders) literature support. See Table 2 for details.

Figure 4

doi: https://doi.org/10.1371/journal.pgen.1004122.g004