Coherent Functional Modules Improve Transcription Factor Target Identification, Cooperativity Prediction, and Disease Association
Transcription factors are connected solely on the basis of the similarity of the modules that they regulate. Transcription factors are colored according to a selection of diseases; (A, green): AIDS; (B, blue): arrhythmia; (C, pink): breast cancer; (D, red): hemorrhage. Nodes are annotated with strong (dashed black borders) and weak (solid grey borders) literature support. See Table 2 for details.