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Accurate Prediction of Inducible Transcription Factor Binding Intensities In Vivo

Figure 4

Genomic chromatin and PB–seq data accurately predict in vivo HSF binding intensity.

A) The intensity of in vivo ChIP-seq peaks is not recapitulated by in vitro PB–seq data; however, genomic DNase I hypersensitivity data and histone modification ChIP-chip data can be used to accurately predict HSF binding intensity. B) The experimentally determined ratio between in vivo ChIP-seq HSF intensity and in vitro PB–seq intensity is plotted against the predicted in vivo/actual PB–seq ratio. The Pearson correlation for each model is shown.

Figure 4