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Accurate Prediction of Inducible Transcription Factor Binding Intensities In Vivo

Figure 3

In vitro and in vivo binding of HSF to genomic HSEs do not correlate.

A) A scatter plot comparing the observed in vivo HSF binding intensity and in vitro binding intensity for each isolated HSE indicates that the vast majority of in vivo binding is suppressed (green) or abolished (blue), if we assume that the top seven most DNase I hypersensitive isolated HSE clusters provide the best estimates for sites that are minimally influenced by chromatin. After scaling, red points have similar in vivo and in vitro intensity, black points may be enhanced in vivo, while green and blue points are suppressed and abolished, respectively. B) The points from panel A were categorized, and the resulting bar chart shows the relative frequencies of each category.

Figure 3