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Zelda Binding in the Early Drosophila melanogaster Embryo Marks Regions Subsequently Activated at the Maternal-to-Zygotic Transition

Figure 5

Early ZLD binding predicts chromatin state at the MZT.

(A) Histogram of DNA accessibility based on DNaseI hypersensitivity from [20] among the most strongly bound 1,000 ZLD peaks at cycle 8 (red) and among randomly shuffled peak positions (blue). (B) Comparison of genome-wide ZLD binding at cycle 8 (x-axis) vs. the DNaseI hypersensitivity values at cycle 14 [20], showing a genome-wide correlation coefficient of 0.27 (C) Same as (B), but using ZLD binding from late cycle 14, showing correlation coefficient of 0.43.

Figure 5