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U87MG Decoded: The Genomic Sequence of a Cytogenetically Aberrant Human Cancer Cell Line

Figure 7

Increased resolution of structural variations by sequencing.

Resolution of karyotyping and SKY approaches is not high enough to see the complex nature of this translocation event between chr1 and chr16. With high-resolution whole-genome sequencing, the true structure of the translocation is revealed as mutual translocations between a small fragment of chr2 with chr1 and chr16 on either end.

Figure 7