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A Robust Approach to Identifying Tissue-Specific Gene Expression Regulatory Variants Using Personalized Human Induced Pluripotent Stem Cells

Figure 8

Visualizing the mapped ASE loci in multiple tissue types.

(A) In order to see if mappable ASE loci depended on the tissue type being examined, we examined 317 expression SNPs present in at least 16 out of 20 samples. Mapped ASE loci (red), unmapped ASE loci (black) and missing ASE loci (gray) were hierarchical clustered to reveal tissue-specific sample clustering. (B) When one of the most significant cluster mapping nodes (0.72 correlation) were examined, we found 29 expression SNPs that were consistently mapped in >80% of the cell types derived from PGP1.

Figure 8

doi: https://doi.org/10.1371/journal.pgen.1000718.g008