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Exome-wide association study to identify rare variants influencing COVID-19 outcomes: Results from the Host Genetics Initiative
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Guillaume Butler-Laporte,
Roles Conceptualization, Data curation, Formal analysis, Investigation, Project administration, Visualization, Writing – original draft, Writing – review & editing
Affiliations Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Montréal, Québec, Canada, Lady Davis Institute, Jewish General Hospital, McGill University, Montréal, Québec, Canada
⨯ -
Gundula Povysil,
Roles Data curation, Formal analysis, Investigation, Methodology, Writing – review & editing
Affiliation Institute for Genomic Medicine, Columbia University, New York city, New York, United States of America
⨯ -
Jack A. Kosmicki,
Roles Conceptualization, Data curation, Formal analysis, Investigation, Writing – review & editing
Affiliation Regeneron Genetics Center, Tarrytown, New York, United States of America
⨯ -
Elizabeth T. Cirulli,
Roles Conceptualization, Data curation, Formal analysis, Investigation, Resources, Supervision, Writing – review & editing
Affiliation Helix, San Mateo, California, United States of America
⨯ -
Theodore Drivas,
Roles Conceptualization, Data curation, Formal analysis, Investigation, Writing – review & editing
Affiliations Division of Human Genetics, Department of Pediatrics, Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America, Division of Translational Medicine and Human Genetics, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America, Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
⨯ - Simone Furini,
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Chadi Saad,
Roles Conceptualization, Data curation, Formal analysis, Investigation, Writing – review & editing
Affiliation Qatar Genome Program, Qatar Foundation Research, Development and Innovation, Qatar Foundation, Doha, Qatar
⨯ - Axel Schmidt,
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Pawel Olszewski,
Roles Conceptualization, Data curation, Formal analysis, Investigation, Writing – review & editing
Affiliation IMAGENE.ME SA, Bialystok, Poland
⨯ -
Urszula Korotko,
Roles Investigation, Writing – review & editing
Affiliations IMAGENE.ME SA, Bialystok, Poland, Centre for Bioinformatics and Data Analysis, Medical University of Bialystok, Bialystok, Poland
⨯ -
Mathieu Quinodoz,
Roles Conceptualization, Data curation, Formal analysis, Investigation, Writing – review & editing
Affiliations Institute of Molecular and Clinical Ophthalmology Basel (IOB), Basel, Switzerland, Department of Genetics and Genome Biology, University of Leicester, Leicester, United Kingdom, Department of Ophthalmology, University Hospital Basel, Basel, Switzerland
⨯ -
Elifnaz Çelik,
Roles Conceptualization, Data curation, Formal analysis, Investigation, Writing – review & editing
Affiliations Institute of Molecular and Clinical Ophthalmology Basel (IOB), Basel, Switzerland, Department of Ophthalmology, University Hospital Basel, Basel, Switzerland
⨯ -
Kousik Kundu,
Roles Conceptualization, Data curation, Formal analysis, Investigation, Writing – review & editing
Affiliations Department of Haematology, University of Cambridge, Cambridge, United Kingdom, Department of Human Genetics, Wellcome Sanger Institute, Hinxton, United Kingdom
⨯ -
Klaudia Walter,
Roles Data curation, Formal analysis, Investigation, Resources, Supervision, Writing – review & editing
Affiliation Department of Human Genetics, Wellcome Sanger Institute, Hinxton, United Kingdom
⨯ - Junghyun Jung,
- Amy D. Stockwell,
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Laura G. Sloofman,
Roles Data curation, Formal analysis, Investigation, Writing – review & editing
Affiliation Seaver Autism Center for Research and Treatment, Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York city, New York, United States of America
⨯ -
Daniel M. Jordan,
Roles Investigation, Writing – review & editing
Affiliation Mount Sinai Clnical Intelligence Center, Charles Bronfman Institute for Personalized Medicine, Department of Genetics & Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York city, New York, United States of America
⨯ -
Ryan C. Thompson,
Roles Investigation, Writing – review & editing
Affiliation Icahn Institute of Data Science and Genomics Technology, New York city, New York, United States of America
⨯ -
Diane Del Valle,
Roles Investigation, Writing – review & editing
Affiliation Icahn School of Medicine at Mount Sinai, New York city, New York, United States of America
⨯ -
Nicole Simons,
Roles Investigation, Writing – review & editing
Affiliation Icahn School of Medicine at Mount Sinai, New York city, New York, United States of America
⨯ - Esther Cheng,
- Robert Sebra,
- Eric E. Schadt,
- Seunghee Kim-Schulze,
- Sacha Gnjatic,
- Miriam Merad,
- Joseph D. Buxbaum,
- Noam D. Beckmann,
- Alexander W. Charney,
- Bartlomiej Przychodzen,
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Timothy Chang,
Roles Data curation, Formal analysis, Investigation, Writing – review & editing
Affiliation Department of Neurology, David Geffen School of Medicine, University of California—Los Angeles, Los Angeles, California, United States of America
⨯ - Tess D. Pottinger,
- Ning Shang,
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Fabian Brand,
Roles Investigation, Writing – review & editing
Affiliation Institute of Genomic Statistics and Bioinformatics, School of Medicine and University Hospital Bonn, University of Bonn, Bonn, Germany
⨯ - Francesca Fava,
- Francesca Mari,
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Karolina Chwialkowska,
Roles Investigation, Writing – review & editing
Affiliations IMAGENE.ME SA, Bialystok, Poland, Centre for Bioinformatics and Data Analysis, Medical University of Bialystok, Bialystok, Poland
⨯ -
Magdalena Niemira,
Roles Investigation, Writing – review & editing
Affiliation Centre for Clinical Research, Medical University of Bialystok, Bialystok, Poland
⨯ - Szymon Pula,
- J Kenneth Baillie,
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Alex Stuckey,
Roles Formal analysis, Investigation, Writing – review & editing
Affiliation Genomics England, London, United Kingdom
⨯ - Antonio Salas,
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Xabier Bello,
Roles Investigation, Writing – review & editing
Affiliations Unidade de Xenética, Instituto de Ciencias Forenses (INCIFOR), Facultade de Medicina, Universidade de Santiago de Compostela, and GenPoB Research Group, Instituto de Investigaciones Sanitarias, Hospital Clínico Universitario de Santiago (SERGAS), Santiago de Compostela, Galicia, Spain, Genetics, Vaccines and Infections Research Group (GENVIP), Instituto de Investigación Sanitaria de Santiago, Santiago de Compostela, Spain, Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBER-ES), Madrid, Spain
⨯ - Jacobo Pardo-Seco,
- Alberto Gómez-Carballa,
- Irene Rivero-Calle,
- Federico Martinón-Torres,
- Andrea Ganna,
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Konrad J. Karczewski,
Roles Investigation, Writing – review & editing
Affiliations Stanley Center for Psychiatric Genetics, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, United States of America, Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, Massachusetts, United States of America
⨯ - Kumar Veerapen,
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Mathieu Bourgey,
Roles Investigation, Resources, Writing – review & editing
Affiliations Canadian Centre for Computational Genomics, McGill University, Montréal, Québec, Canada, McGill Genome Center, McGill University, Montréal, Québec, Canada
⨯ -
Guillaume Bourque,
Roles Investigation, Resources, Writing – review & editing
Affiliations Canadian Centre for Computational Genomics, McGill University, Montréal, Québec, Canada, McGill Genome Center, McGill University, Montréal, Québec, Canada, Department of Human Genetics, McGill University, Montréal, Québec, Canada
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Robert JM Eveleigh,
Roles Investigation, Resources, Writing – review & editing
Affiliations Canadian Centre for Computational Genomics, McGill University, Montréal, Québec, Canada, McGill Genome Center, McGill University, Montréal, Québec, Canada
⨯ - Vincenzo Forgetta,
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David Morrison,
Roles Investigation, Resources, Writing – review & editing
Affiliation Lady Davis Institute, Jewish General Hospital, McGill University, Montréal, Québec, Canada
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David Langlais,
Roles Investigation, Writing – review & editing
Affiliations McGill Genome Center, McGill University, Montréal, Québec, Canada, Department of Human Genetics, McGill University, Montréal, Québec, Canada
⨯ - Mark Lathrop,
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Vincent Mooser,
Roles Investigation, Resources, Supervision, Writing – review & editing
Affiliation Department of Human Genetics, McGill University, Montréal, Québec, Canada
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Tomoko Nakanishi,
Roles Conceptualization, Investigation, Writing – review & editing
Affiliations Lady Davis Institute, Jewish General Hospital, McGill University, Montréal, Québec, Canada, Department of Human Genetics, McGill University, Montréal, Québec, Canada, Kyoto-McGill International Collaborative School in Genomic Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan, Research Fellow, Japan Society for the Promotion of Science, Tokyo, Japan
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Robert Frithiof,
Roles Investigation, Resources, Supervision, Writing – review & editing
Affiliation Anaesthesiology and Intensive Care Medicine, Department of Surgical Sciences, Uppsala University, Uppsala, Sweden
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Michael Hultström,
Roles Investigation, Resources, Supervision, Writing – review & editing
Affiliations Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Montréal, Québec, Canada, Lady Davis Institute, Jewish General Hospital, McGill University, Montréal, Québec, Canada, Anaesthesiology and Intensive Care Medicine, Department of Surgical Sciences, Uppsala University, Uppsala, Sweden, Integrative Physiology, Department of Medical Cell Biology, Uppsala University, Uppsala, Sweden
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Miklos Lipcsey,
Roles Investigation, Resources, Supervision, Writing – review & editing
Affiliations Anaesthesiology and Intensive Care Medicine, Department of Surgical Sciences, Uppsala University, Uppsala, Sweden, Hedenstierna Laboratory, CIRRUS, Anaesthesiology and Intensive Care Medicine, Department of Surgical Sciences, Uppsala University, Uppsala, Sweden
⨯ - Yanara Marincevic-Zuniga,
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Jessica Nordlund,
Roles Investigation, Writing – review & editing
Affiliation Department of Medical Sciences, Science for Life Laboratory, Uppsala University, Uppsala, Sweden
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Kelly M. Schiabor Barrett,
Roles Investigation, Writing – review & editing
Affiliation Helix, San Mateo, California, United States of America
⨯ - William Lee,
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Alexandre Bolze,
Roles Investigation, Writing – review & editing
Affiliation Helix, San Mateo, California, United States of America
⨯ -
Simon White,
Roles Investigation, Writing – review & editing
Affiliation Helix, San Mateo, California, United States of America
⨯ - Stephen Riffle,
- Francisco Tanudjaja,
- Efren Sandoval,
- Iva Neveux,
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Shaun Dabe,
Roles Investigation, Writing – review & editing
Affiliation Renown Health, Reno, Nevada, United States of America
⨯ -
Nicolas Casadei,
Roles Investigation, Writing – review & editing
Affiliations Institute of Medical Genetics and Applied Genomics, University of Tuebingen, Tuebingen, Germany, NGS Competence Center Tuebingen, Institute of Medical Genetics and Applied Genomics, University of Tuebingen, Tuebingen, Germany
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Susanne Motameny,
Roles Investigation, Writing – review & editing
Affiliations West German Genome Center, site Cologne, University of Cologne, Cologne, Germany, Cologne Center for Genomics, University of Cologne, Cologne, Germany
⨯ - Manal Alaamery,
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Salam Massadeh,
Roles Investigation, Writing – review & editing
Affiliations Developmental Medicine Department, King Abdullah International Medical Research Center, King Saud Bin Abdulaziz University for Health Sciences, King Abdulaziz Medical City, Ministry of National Guard Health Affairs, Riyadh, Saudi Arabia, Saudi Human Genome Project at King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia
⨯ - Nora Aljawini,
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Mansour S. Almutairi,
Roles Investigation, Writing – review & editing
Affiliations Developmental Medicine Department, King Abdullah International Medical Research Center, King Saud Bin Abdulaziz University for Health Sciences, King Abdulaziz Medical City, Ministry of National Guard Health Affairs, Riyadh, Saudi Arabia, Saudi Human Genome Project at King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia
⨯ -
Yaseen M. Arabi,
Roles Investigation, Writing – review & editing
Affiliation Ministry of the National Guard Health Affairs, King Abdullah International Medical Research Center and King Saud Bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia
⨯ - Saleh A. Alqahtani,
- Fawz S. Al Harthi,
- Amal Almutairi,
- Fatima Alqubaishi,
- Sarah Alotaibi,
- Albandari Binowayn,
- Ebtehal A. Alsolm,
- Hadeel El Bardisy,
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Mohammad Fawzy,
Roles Investigation, Writing – review & editing
Affiliation Genomics Research Department, Saudi Human Genome Project, King Fahad Medical City and King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia
⨯ - Fang Cai,
- Nicole Soranzo,
- Adam Butterworth,
- COVID-19 Host Genetics Initiative ,
- DeCOI Host Genetics Group ,
- GEN-COVID Multicenter Study (Italy) ,
- Mount Sinai Clinical Intelligence Center ,
- GEN-COVID consortium (Spain) ,
- GenOMICC Consortium ,
- Japan COVID-19 Task Force ,
- Regeneron Genetics Center ,
- Daniel H. Geschwind,
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Stephanie Arteaga,
Roles Investigation, Writing – review & editing
Affiliation Department of Neurology, David Geffen School of Medicine, University of California—Los Angeles, Los Angeles, California, United States of America
⨯ -
Alexis Stephens,
Roles Investigation, Writing – review & editing
Affiliation Department of Pediatrics, David Geffen School of Medicine, University of California—Los Angeles, Los Angeles, California, United States of America
⨯ - Manish J. Butte,
- Paul C. Boutros,
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Takafumi N. Yamaguchi,
Roles Investigation, Writing – review & editing
Affiliation Department of Human Genetics, David Geffen School of Medicine, University of California—Los Angeles, Los Angeles, California, United States of America
⨯ - Shu Tao,
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Stefan Eng,
Roles Investigation, Writing – review & editing
Affiliation Department of Human Genetics, David Geffen School of Medicine, University of California—Los Angeles, Los Angeles, California, United States of America
⨯ - Timothy Sanders,
- Paul J. Tung,
- Michael E. Broudy,
- Yu Pan,
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Alfredo Gonzalez,
Roles Investigation, Writing – review & editing
Affiliation Department of Human Genetics, David Geffen School of Medicine, University of California—Los Angeles, Los Angeles, California, United States of America
⨯ - Nikhil Chavan,
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Ruth Johnson,
Roles Investigation, Writing – review & editing
Affiliation Department of Computer Science, McGill University, Montréal, Québec, Canada
⨯ - Bogdan Pasaniuc,
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Brian Yaspan,
Roles Investigation, Resources, Supervision, Writing – review & editing
Affiliation Genentech Inc, South San Francisco, California, United States of America
⨯ -
Sandra Smieszek,
Roles Investigation, Resources, Supervision, Writing – review & editing
Affiliation Vanda Pharmaceuticals, Washington, District of Columbia, United States of America
⨯ -
Carlo Rivolta,
Roles Investigation, Resources, Supervision, Writing – review & editing
Affiliations Institute of Molecular and Clinical Ophthalmology Basel (IOB), Basel, Switzerland, Department of Genetics and Genome Biology, University of Leicester, Leicester, United Kingdom, Department of Ophthalmology, University Hospital Basel, Basel, Switzerland
⨯ - Stephanie Bibert,
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Pierre-Yves Bochud,
Roles Investigation, Resources, Supervision, Writing – review & editing
Affiliation Infectious Diseases Service, Department of Medicine, University Hospital and University of Lausanne, Lausanne, Switzerland
⨯ -
Maciej Dabrowski,
Roles Investigation, Writing – review & editing
Affiliation MNM Bioscience Inc., Cambridge, Massachusetts, United States of America
⨯ -
Pawel Zawadzki,
Roles Investigation, Writing – review & editing
Affiliations MNM Bioscience Inc., Cambridge, Massachusetts, United States of America, Faculty of Physics, Adam Mickiewicz University, Poznan, Poland
⨯ - Mateusz Sypniewski,
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Elżbieta Kaja,
Roles Investigation, Resources, Supervision, Writing – review & editing
Affiliations MNM Bioscience Inc., Cambridge, Massachusetts, United States of America, Department of Medical Chemistry and Laboratory Medicine, Poznań University of Medical Sciences, Poznań, Poland
⨯ -
Pajaree Chariyavilaskul,
Roles Investigation, Writing – review & editing
Affiliation Clinical Pharmacokinetics and Pharmacogenomics Research Unit, Department of Pharmacology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand
⨯ -
Voraphoj Nilaratanakul,
Roles Investigation, Writing – review & editing
Affiliation Healthcare-associated Infection Research Group STAR (Special Task Force for Activating Research) and Division of Infectious Diseases, Department of Medicine,Chulalongkorn University, Bangkok, Thailand
⨯ -
Nattiya Hirankarn,
Roles Investigation, Writing – review & editing
Affiliation Center of Excellence in Immunology and Immune-mediated Diseases, Department of Microbiology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand
⨯ -
Vorasuk Shotelersuk,
Roles Investigation, Writing – review & editing
Affiliation Center of Excellence for Medical Genomics, Medical Genomics Cluster, and Department of Pediatrics, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand
⨯ -
Monnat Pongpanich,
Roles Investigation, Writing – review & editing
Affiliation Department of Mathematics and Computer Science, Faculty of Science, Chulalongkorn University, Bangkok, Thailand
⨯ -
Chureerat Phokaew,
Roles Investigation, Writing – review & editing
Affiliation Research Affairs, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand
⨯ -
Wanna Chetruengchai,
Roles Investigation, Writing – review & editing
Affiliation Center of Excellence for Medical Genomics, Medical Genomics Cluster, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand
⨯ - Katsushi Tokunaga,
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Masaya Sugiyama,
Roles Investigation, Writing – review & editing
Affiliation Genome Medical Science Project, Research Institute, National Center for Global Health and Medicine, Shinjuku-ku, Tokyo, Japan
⨯ -
Yosuke Kawai,
Roles Data curation, Formal analysis, Investigation, Resources, Supervision, Writing – review & editing
Affiliation Genome Medical Science Project, National Center for Global Health and Medicine (NCGM), Tokyo, Japan
⨯ -
Takanori Hasegawa,
Roles Investigation, Writing – review & editing
Affiliation M&D Data Science Center, Tokyo Medical and Dental University, Tokyo, Japan
⨯ - Tatsuhiko Naito,
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Ho Namkoong,
Roles Investigation, Writing – review & editing
Affiliation Department of Infectious Diseases, Keio University School of Medicine, Tokyo, Japan
⨯ - Ryuya Edahiro,
- Akinori Kimura,
- Seishi Ogawa,
- Takanori Kanai,
- Koichi Fukunaga,
- Yukinori Okada,
- Seiya Imoto,
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Satoru Miyano,
Roles Investigation, Writing – review & editing
Affiliation M&D Data Science Center, Tokyo Medical and Dental University, Tokyo, Japan
⨯ -
Serghei Mangul,
Roles Investigation, Resources, Supervision, Writing – review & editing
Affiliation Department of Clinical Pharmacy, School of Pharmacy, University of Southern California, Los Angeles, California, United States of America
⨯ - Malak S. Abedalthagafi,
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Hugo Zeberg,
Roles Conceptualization, Investigation, Resources, Supervision, Writing – review & editing
Affiliation Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden
⨯ -
Joseph J. Grzymski,
Roles Investigation, Writing – review & editing
Affiliation Center for Genomic Medicine, Desert Research Institute, Reno, Nevada United States of America
⨯ - Nicole L. Washington,
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Stephan Ossowski,
Roles Conceptualization, Investigation, Resources, Supervision, Writing – review & editing
Affiliations Institute of Medical Genetics and Applied Genomics, University of Tuebingen, Tuebingen, Germany, NGS Competence Center Tuebingen, Institute of Medical Genetics and Applied Genomics, University of Tuebingen, Tuebingen, Germany
⨯ -
Kerstin U. Ludwig,
Roles Conceptualization, Data curation, Investigation, Resources, Supervision, Writing – review & editing
Affiliations Institute of Human Genetics, School of Medicine and University Hospital Bonn, University of Bonn, Bonn, Germany, West German Genome Center, site Bonn, University of Bonn, Bonn, Germany
⨯ -
Eva C. Schulte,
Roles Conceptualization, Investigation, Resources, Supervision, Writing – review & editing
Affiliations Institute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, LMU Munich, Munich, Germany, Department of Psychiatry and Psychotherapy, University Hospital, LMU Munich, Munich, Germany, Institute of Virology, Technical University Munich/Helmholtz Zentrum München, Munich, Germany
⨯ - Olaf Riess,
- Marcin Moniuszko,
- Miroslaw Kwasniewski,
- Hamdi Mbarek,
- Said I. Ismail,
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Anurag Verma,
Roles Investigation, Resources, Supervision, Writing – review & editing
Affiliations Division of Translational Medicine and Human Genetics, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America, Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America, Corporal Michael Crescenz VA Medical Center, Philadelphia, Pennsylvania, United States of America
⨯ -
David B. Goldstein,
Roles Conceptualization, Investigation, Project administration, Resources, Supervision, Writing – review & editing
Affiliations Institute for Genomic Medicine, Columbia University, New York city, New York, United States of America, Department of Genetics & Development, Columbia University, New York city, New York, United States of America
⨯ -
Krzysztof Kiryluk,
Roles Conceptualization, Investigation, Project administration, Resources, Supervision, Writing – review & editing
Affiliations Institute for Genomic Medicine, Columbia University, New York city, New York, United States of America, Division of Nephrology, Department of Medicine, Vagelos College of Physicians & Surgeons, Columbia University, New York city, New York, United States of America
⨯ -
Alessandra Renieri,
Roles Conceptualization, Formal analysis, Investigation, Project administration, Resources, Supervision, Writing – review & editing
Affiliations Department of Medical Biotechnologies, Med Biotech Hub and Competence Center, University of Siena, Siena, Italy, Genetica Medica, Azienda Ospedaliero-Universitaria Senese, Siena, Italy, Medical Genetics, University of Siena, Siena, Italy
⨯ - Manuel A. R. Ferreira,
- [ ... ],
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J Brent Richards
Roles Conceptualization, Project administration, Resources, Supervision, Writing – review & editing
* E-mail: brent.richards@mcgill.ca
Affiliations Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Montréal, Québec, Canada, Lady Davis Institute, Jewish General Hospital, McGill University, Montréal, Québec, Canada, Department of Human Genetics, McGill University, Montréal, Québec, Canada, Infectious Diseases and Immunity in Global Health Program, Research Institute of the McGill University Health Centre, Montréal, Québec, Canada, Department of Twin Research, King’s College London, London, United Kingdom, 5 Prime Sciences Inc, Montreal, Quebec, Canada
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https://orcid.org/0000-0001-5388-0396
Exome-wide association study to identify rare variants influencing COVID-19 outcomes: Results from the Host Genetics Initiative
- Guillaume Butler-Laporte,
- Gundula Povysil,
- Jack A. Kosmicki,
- Elizabeth T. Cirulli,
- Theodore Drivas,
- Simone Furini,
- Chadi Saad,
- Axel Schmidt,
- Pawel Olszewski,
- Urszula Korotko
- Published: November 3, 2022
- https://doi.org/10.1371/journal.pgen.1010367
- See the preprint